ALI Specialist Clinic Lahore

09/08/2025

09/08/2025

Shalender Bhasin, MB, BS, and Peter J. Snyder, MD, review available data on the benefits and risks of testosterone treatment in middle-aged and older men with moderate hypogonadism.

09/08/2025

NADH reductive stress drives metabolic reprogramming

NADH reductive stress is usually caused by mitochondrial dysfunction, hypoxia, nutrient overload, malfunction of certain metabolic enzymes, or alcohol metabolism.

NADH reductive stress drives metabolic reprogramming, exerting significant impacts over glucose, lipid, amino acid, and nucleotide metabolic pathways.

Through its crosstalk with oxidative and energy stress, especially by enhancing reactive oxygen species production and reducing ATP levels, NADH reductive stress serves as a central mediator in various disorders, including metabolic diseases, cancer, and neurodegenerative diseases.

Targeting NADH reductive stress can be therapeutic for related diseases.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00157-6
https://sciencemission.com/NADH-reductive-stress

09/08/2025

Take it from people who have lost weight and kept it off:

🥗 98% modified their eating habits.
🚶‍♀️ 94% increased their physical activity, especially walking.

09/08/2025

Independence Day Special for Our Senior Citizens! 🇵🇰
Farooq Hospital DHA is celebrating Pakistan’s 78th Independence Day with love and care for our elders. 💚

👴👵 Citizens aged 70+ can enjoy UP TO 50% OFF on all Lab Tests from 10th to 14th August 2025.

📍 Visit Farooq Hospital DHA and avail this special offer dedicated to the health and happiness of our seniors.
📞 Call: 042-35729756 to book your appointment today.

Let’s make this Independence Day healthier for those who’ve given us a lifetime of love. 💐

05/08/2025

The case series of -associated acute necrotizing encephalopathy in US children during the 2023-2024 and 2024-2025 influenza seasons found high morbidity and mortality among primarily young and previously healthy children.

https://ja.ma/3Hd0ZeN

04/08/2025

03/08/2025

, an inflammatory condition of diverticula, affects roughly 180 per 100 000 people annually in the US, predominantly in older adults.

This Review summarizes current evidence regarding the pathogenesis, etiology, diagnosis, and treatment of diverticulitis.

https://ja.ma/3TRg093

03/08/2025

Vitamin D reduces liver damage

Vitamin D is commonly consumed for enhanced bone health. This study opens exciting possibilities for repurposing an inexpensive supplement as a complementary therapy for liver diseases. The researchers have studied the underlying mechanisms and therapeutic implications of Vitamin D in liver disease.

Ductular reaction refers to the proliferation of ductular cells (primarily cholangiocytes) in response to liver injury. While initially protective, excessive or prolonged ductular reaction contributes to inflammation and fibrosis. In this study, researchers observed that lower plasma levels of vitamin D were associated with more severe ductular reaction in patients with chronic liver disease (CLD).

Vitamin D upregulates the expression of TXNIP (Thioredoxin-interacting protein). This was confirmed in a mouse study where Txnip deletion in cholangiocytes promoted ductular reaction and even exacerbated liver inflammation and fibrosis. In vitro analysis revealed the Vitamin D/TXNIP molecular axis. “Furthermore, Txnip deficiency increases TNF-α and TGF-β secretion by cholangiocytes to stimulate Kupffer cells and hepatic stellate cells, consequently leading to inflammation and collagen deposition,” adds the author.

https://sciencemission.com/Vitamin-D-reduces-liver-damage

02/08/2025

Use of GLP-1s, especially semaglutide and liraglutide, may increase risk for nonarteritic anterior ischemic optic neuropathy in older patients with type 2 diabetes, a study of Medicare enrollees shows. http://ms.spr.ly/6189sK3if

01/08/2025

Eastern equine encephalitis (EEE) is a potentially life-threatening viral infection spread by mosquitoes in the eastern US.

This JAMA Patient Page describes EEE and its symptoms, diagnosis, treatment, prognosis, and prevention measures.

https://ja.ma/3IU8lEH