09/08/2023
Your teeth, gums, and jawbones are a living, breeding site of human stem cells. That’s the ability to self-renew. Does that mean you can just grow teeth back? No, but it represents a leap we need to take in our perception of dental health.⠀
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It’s a testament to the fact that bone and teeth formation is very similar to immune system formation.⠀
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In the year 2000, adult human dental stem cells were first identified in the dental pulp. Teeth contain these so that they can self-renew.⠀
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Teeth can self-renew.⠀
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Stem cells are immature cells that have the potential to develop into many different cell lineages via differentiation. These cells can renew themselves indefinitely through “self-renewal”. A fluid equilibrium, and constant flux.⠀
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The question is whether they do ‘self renew’ or not. That relies on receiving the right ‘resources’ from the body.⠀
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Bone cells, act much like immune cells. They listen and adapt to the environment, and use resources to do so. When the immune system is depleted of resources, it cannot fight infections.⠀
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When the bone and teeth system is depleted, it can cannot form new repair bone and teeth cells to replenish mineral contents.⠀
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The jaw, teeth, and gums have the ability to self-renew itself. Whether they do or not depends on whether we provide the right resources.⠀
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In the above image, are all the scientifically isolated sites of different stem cells in the mouth.⠀
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The human jawbone for example has been shown to have specific stem cells that experimental studies have shown to be more effective than grafted bone from the hip region.⠀
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In animal studies, as well as tissue repair and regeneration, stem cells have immunomodulatory properties that can have therapeutic effects such as anti-inflammation.⠀
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Inside the pulp of each tooth is a soup of dental tissues, these are the cells known to repair dentin, if decay breaches the tooth enamel.⠀
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Similarly, stem cells can regenerate bone loss around the teeth.⠀
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The mouth is a living, breathing, immune system that can repair itself if given the right resources.
What do you think could be achieved with dental stem cells?