Dr Zuhad Murad Ali

04/01/2026

❇️ PROBIOTICS vs PREBIOTICS
Basic Concept

Probiotics → Live microorganisms that may provide health benefits when taken in adequate amounts

Prebiotics → Non-digestible food components that selectively stimulate the growth or activity of beneficial gut bacteria

PROBIOTICS

→ Live microorganisms (commonly Lactobacillus, Bifidobacterium, Saccharomyces boulardii)
→ Benefit is strain-specific and condition-specific

Mechanisms of Action

→ Temporary modulation of gut microbiota
→ Competitive inhibition of pathogenic bacteria
→ Enhancement of intestinal barrier function
→ Modulation of immune responses
→ Production of antimicrobial substances

(Most probiotics do not permanently colonize the gut)

Common Sources

→ Yogurt/curd with live cultures
→ Kefir
→ Fermented foods (kimchi, sauerkraut, miso)
→ Probiotic supplements

Clinical Uses (Evidence-Based)

→ Antibiotic-associated diarrhea
→ Prevention of Clostridioides difficile–associated diarrhea (selected strains)
→ Infantile colic (some strains)
→ Irritable bowel syndrome (symptom relief in some patients)
→ Acute infectious diarrhea (adjunctive)

Limitations & Safety

→ Effects vary by strain, dose, formulation
→ Benefits are modest in many conditions
→ Usually safe in healthy individuals
→ Avoid or use cautiously in:
→ Severe immunocompromise
→ Critical illness
→ Patients with central venous catheters
→ Premature infants (strain-dependent risk)

PREBIOTICS

→ Non-digestible carbohydrates that are selectively fermented by beneficial gut bacteria

Common Types

→ Inulin
→ Fructo-oligosaccharides (FOS)
→ Galacto-oligosaccharides (GOS)
→ Resistant starch

Mechanisms of Action

→ Promote growth of beneficial microbes
→ Increase short-chain fatty acid (SCFA) production
→ Improve gut barrier function
→ Support metabolic and immune health

Common Sources

→ Garlic
→ Onion
→ Leeks
→ Banana
→ Oats
→ Chicory root
→ Whole grains and legumes

Clinical Benefits

→ Improve stool frequency and consistency
→ Support gut microbiota diversity
→ May improve calcium absorption
→ May aid metabolic health

Limitations

→ Excess intake may cause bloating or gas
→ Effects depend on individual gut microbiota

SYNBIOTICS

→ Combination of probiotics + prebiotics designed to act synergistically

Clinical Role

→ Prebiotics may enhance activity of administered probiotics
→ Used in selected GI conditions
→ Not required for probiotic survival, but may improve efficacy

04/01/2026

Why Many Chronic Conditions Fail to Improve in Pakistan — And What a Holistic, Evidence-Based Approach Really Means ?

In daily clinical practice, I often meet patients who have been suffering for years. They are tired—not just physically, but emotionally—after moving from one doctor to another, trying different medicines, diets, and even alternative therapies, yet never feeling truly better.

One of the most common groups of such conditions is Disorders of Gut–Brain Interaction (DGBIs). These include problems like IBS, functional dyspepsia, chronic bloating, gut dysbiosis, and stress-related gut symptoms. These are real, biological conditions—but they do not respond well to a single-organ, symptom-only approach.

DGBIs require understanding the gut–brain connection, inflammation, microbiome imbalance, stress physiology, nutrition, sleep, and lifestyle. Treating them with only antispasmodics, PPIs, antidepressants, or probiotics—without context—often leads to frustration and failure.

However, DGBIs are not the only conditions that suffer because of fragmented care.
Beyond DGBIs there are other many Conditions that Fail with a Fragmented Approach.
Many chronic diseases do not fit neatly into one specialty. When they are treated in isolation, outcomes remain poor.

Metabolic and lifestyle-related diseases such as type 2 diabetes, obesity, fatty liver disease, dyslipidemia, and resistant hypertension often remain “controlled on paper” but uncontrolled in real life. Medicines are prescribed, but nutrition, sleep, stress, and insulin resistance are not adequately addressed.

Autoimmune and inflammatory conditions like Hashimoto’s thyroiditis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, and chronic allergies are frequently managed with suppression alone, while gut health, micronutrient deficiencies, chronic inflammation, and lifestyle triggers are overlooked.

Chronic pain and fatigue syndromes—including fibromyalgia, chronic fatigue, migraines, and unexplained body pains—are often dismissed once routine tests come back normal. Patients are told “everything is fine” while their quality of life continues to decline.

Hormonal and endocrine problems such as PCOS, persistent hypothyroid symptoms, perimenopausal complaints, and metabolic hormone imbalance are treated with prescriptions but without correcting the underlying metabolic and inflammatory environment.

Mental health conditions like anxiety, depression, panic symptoms, and brain fog frequently coexist with gut dysfunction, inflammation, sleep disorders, anemia, vitamin deficiencies, and thyroid disease. Treating the mind while ignoring the body—or vice versa—rarely succeeds.

Even chronic skin conditions such as acne, eczema, urticaria, and rosacea often reflect internal metabolic, immune, or gut-related issues rather than just a skin problem.

Why such Patients Often Get Discouraged in Pakistan ?

Many patients lose hope not because their condition is untreatable, but because care is fragmented.
They move between:
Internal medicine specialists
Gastroenterologists
Psychiatrists
Homeopaths and hakeems
And unfortunately, sometimes quacks
Each looks at one piece of the puzzle. No one connects the dots. Appointments are short. Explanations are limited. Patients are given medicines but not understanding.
These conditions cannot be fixed by one test, one pill, or one visit.

What Actually Works
Chronic and complex conditions—especially DGBIs and related disorders—require:
Detailed and patient listening
Thorough medical history
Appropriate baseline and selected special investigations
Individualized nutritional counselling
Lifestyle and sleep optimization
Psychological support or psychotherapy when needed
And above all, evidence-based medicine applied holistically
This is not alternative medicine, and it is not guesswork. It is good medicine practiced properly.

My Approach
I practice an integrative, functional (root-cause–oriented), and lifestyle-focused approach, firmly grounded in evidence-based medicine (Conventional Medicine / Allopathic / Western Medicine). Over the years, I have managed thousands of patients with DGBIs, gut dysbiosis, metabolic, hormonal, and chronic inflammatory conditions, with very encouraging outcomes.

Healing in such conditions is a process, not a shortcut—but when the whole person is treated, real improvement becomes possible.

Dr. Zuhad Murad Ali
MBBS | MRCGP [Int] (UK) | DFM (KMU)
Consultant Family Physician
Special Interest: Treating Mind–Gut & Metabolic Disorders via Conventional, Integrative, Functional & Lifestyle Medicine

Clinic & Online Consults
📞 / WhatsApp: +923271588573

04/01/2026

زیادہ چینی صرف وزن نہیں بڑھاتی بلکہ آنتوں کی صحت بھی ہلا دیتی ہے ! فائدہ مند بیکٹیریا کم کردیتی ہے،نقصان دہ جراثیم زیادہ ہوجاتے ہے، نتیجہ: گیس، پھولاؤ، قبض، سوزش،موڈ خراب، دماغ کا دھندلا پن وغیرہ 💬✍️👇

03/01/2026

Your Gut is Your Second Brain !
میڈیکل کی مونگ وایو ستا سو کولمے ستا سو دویم دماغ دی،کولمو کی دہ بجلے دہ رگونو ڈیر پیچیدہ نظام دے کوم تہ چے اینٹیرک نروس سسٹم یایی کوم کی چی تقریباً100میلین نیوران دی، نیوران ہاعہ حولییCellsدی کوم نہ چ دماغ جوڑ دی👇

01/01/2026

نوے کال مو بختور شہ دہ خیر ، ایمان او روغ صحت سرہ

01/01/2026

سال 2026 بہت بہت مبارک، نیے سال کا تخفہ میرے مریضوں کیلئے :
IBS & Leaky Gut (آئی بی ایس اور لیکی گٹ)
🌿 کیلئے قدرتی سپلیمنٹس
😣 پیٹ درد، گیس، اپھارہ بدہضمی، بڑا پیشاب کھبی سخت کبھی نرم، یاداشت میں کمزوری، تھکاوٹ، نیند میں کمی، گھبراہٹ یہ سارے آئی بی ایس اور لیکی گٹ کے علامات ہے۔
نیچے دیے گئے قدرتی طریقے بہت مددگار ثابت ہو سکتے ہیں 👇
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🌱 Peppermint Oil
➡️ آنتوں کی اینٹھن اور درد میں آرام
💊 خوراک: 1 کیپسول دن میں 2–3 بار
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🦠 Probiotics
➡️ آنتوں کے اچھے بیکٹیریا بہتر بناتے ہیں
💊 خوراک: 5–10 بلین CFU روزانہ
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🫚 ادرک (Ginger)
➡️ بدہضمی، متلی اور سوزش میں مفید
☕ خوراک: 1–2 گرام روزانہ
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🌕 ہلدی (Turmeric)
➡️ آنتوں کی سوزش کم کرتی ہے
💊 خوراک: 500–1000 ملی گرام روزانہ
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⚠️ ہر مریض مختلف ہوتا ہے، استعمال سے پہلے ڈاکٹر سے مشورہ ضروری ہے ، پوسٹ شیر ضرور کریں کسی کو بہت فائد ہوسکتا ہے، شکریہ
ڈاکٹر زوہاد مراد علی
کنسلٹنٹ فیملی فزیشن
ایم بی بی ایس ، ایم آر سی جی پی (انگلینڈ) ، ڈی ایف ایم
ماہر امراض: معدہ ، آنت ، بدہضمی، گیس، آی بی ایس، لیکی گٹ ، سی بو، کینڈیڈیسز، بلڈ پریشر، شوگر، ڈپریشن ، انگزایٹی، موٹاپا ، ہارمونل ایمبیلنس
ایپوانٹمنٹ یا آن لائن کنسلٹیشن :
0937-881152 , 03271588573

31/12/2025

سردی اور ہرٹ آٹیک۔۔

28/12/2025

پیٹ میں جلن یا اوپری حصے میں درد ؟ کھانے کے بعد متلی یا بھرا بھرا پن ؟ یہ گیسٹرائٹس کی علامت ہو سکتی ہے۔ خالی پیٹ، درد کی دوائیں اور ذہنی دباؤ اس کی عام وجوہات ہیں، صحیح علاج اور پرہیز سے واضح بہتری ممکن ہے۔

28/12/2025

Headaches by Dr Zuhad Murad Ali

27/12/2025

26/12/2025

دہ ٹائیفائڈ بخار تشخیص پہ ٹایفیڈاٹ او ویڈال ٹیسٹ کول بلکل غلط دی ! دہ دے تشخیص مونگ پہ علاماتو او بلڈ ، سٹول ، یورین یا بون میرو کلچر باندے کوو، پہ دے زما ویلاگ کمنٹ کی 👇
🙏