
29/08/2025
How to treat Hypertriglyceridemia;(very important)...
Check TG Levels & categorise .
Group 1..Mild -Moderate (150-499mg/dl)
Group 2..Severe (_>500mg/dl
For Group 1 .(150-499mg/dl)
Goal is to just reduce risk of ASCVD ,not to reduce numbers
Step 1..Identify reversible causes & treat
Step 2..If age is >40years then calculate ASCVD risk ,if risk >7.5,then start Statins .if risk >7.5 & also other high risk features then start Statins +icosapent ethyl (2 × 2 g/day) (Class IIa)
Group 2..If LDL >_500mg /dl
Goal is to reduce ASCVD & 2nd goal is to reduce numbers below 500mg/dl to reduce risk of pancreatitis
•Now we have 2 Goals
Goal 1..To reduce risk of ASCVD
Goal 2..To reduce risk of pancreatitis
Step 1..Identify reversible causes & treat
Step 2..Calculate ASCVD risk if age is above 40 & start Statins first ,if pt has other risk factors too ,then give statins +icosapent ethyl (2 × 2 g/day)
Step 3..Add further drugs to reduce risk of pancreatitis to keep TGs level below 500mg/dl.
Recommended further drug is Volanesorsen 300mg/week(Class IIa) by ESC.....
Note ..Fibrates have little use ,almost out in recent ESC & also not how we prescribe it mostly.