29/08/2025
🦷 Tooth regrowth may soon become reality!
Japanese researchers are working on a drug that could give humans the ability to grow a completely new tooth.
The project, led by Dr. Katsu Takahashi at Kitano Hospital, focuses on blocking a protein called USAG-1, which normally stops extra teeth from forming. By switching this protein off, scientists were able to regrow teeth in mice. The next step is human trials, with the goal of making the treatment available to the public by 2030.
For decades, researchers have suspected that people may carry “sleeping” tooth buds for a possible third set of teeth—similar to how sharks and elephants naturally replace theirs. This new discovery brings that idea closer to reality. Combined with progress in dental tissue and bone regeneration, it could transform how tooth loss is treated.
In the near future, losing a tooth might not mean a crown, denture, or implant. It could simply mean waiting for a new natural tooth to grow back.
Source: Ravi, V., Murashima-Suginami, A., Kiso, H., Tokita, Y., Huang, C.L., Bessho, K., Takagi, J., Sugai, M., Tabata, Y., Takahashi, K. Advances in tooth agenesis and tooth regeneration. Regenerative Therapy, Vol 22, March 2023, Pages 160–168.