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The Clinical Psychologist, Rawalpindi (2025)

29/09/2025

Researchers at Osaka University in Japan have identified a drug called IU1 that can significantly slow aging by enhancing the protein quality control systems in cells-and may even open the door to extending human life up to 250 years.

Aging is an inevitable process often accompanied by various diseases. One of the main causes of aging is the loss of protein balance within the body’s cells, a phenomenon known as protestasis. Cells possess mechanisms that identify and break down damaged proteins. However, with aging, these systems become less efficient, paving the way for many age-related degenerative diseases.

In this context, the research team investigated the relationship between two key protein quality control systems: proteasomes and autophagy. They discovered that the lU1 drug can enhance proteasome activity while simultaneously boosting autophagy. This synergistic mechanism could help reduce aging-related muscle weakness and increase lifespan.

$Chinese scientists in Zhejiang Province have developed “Bone-02,” a medical glue that repairs fractures in just three mi...$

25/09/2025

Chinese scientists in Zhejiang Province have developed “Bone-02,” a medical glue that repairs fractures in just three minutes.

Inspired by how oysters cling underwater, the adhesive achieves strong fixation even in blood-rich environments and is naturally absorbed by the body as bones heal, removing the need for follow-up implant surgery.

Lab and clinical tests on over 150 patients showed the glue’s strength rivaled steel plates, with bonding forces over 400 pounds.

Researchers believe Bone-02 could replace traditional metal implants, speeding recovery and reducing surgical risks

25/09/2025

Sleep is when your brain repairs, resets, and recharges, but for that to happen properly, total darkness is essential. Research reveals that even low levels of light, like a dim nightlight, streetlamp glow, or a phone screen, can interfere with your brain's natural rest cycles and damage your mental health over time.

Your brain relies on the sleep hormone melatonin, which is triggered by darkness. When light is present, melatonin production drops, and the body struggles to enter deep, restorative sleep. This prevents the brain from performing its critical nightly functions, clearing toxins, strengthening memory, and regulating mood.

One major study found that even a small amount of ambient light during sleep increases the risk of depression, anxiety, and daytime fatigue. Over time, it may also impair focus, lower immune function, and accelerate cognitive decline.

Your circadian rhythm, the body’s internal clock, is guided by light and dark cycles. Artificial light at night confuses this rhythm, leading to sleep disruptions that ripple into every part of your health.

To protect your brain:
– Turn off all electronics 30 minutes before bed
– Use blackout curtains or a sleep mask
– Avoid LED lights or blue light exposure at night

Quality sleep in complete darkness isn’t a luxury, it’s a neuroscience-backed necessity for your brain to heal, function, and thrive.

23/09/2025

Researchers from Northwestern University and Soochow University built the first gamma ray detector using perovskite crystals, materials better known from solar tech. The camera delivers sharper images at lower radiation doses and costs less than traditional systems. Startup Actinia Inc. is working to bring this breakthrough into hospitals.

22/09/2025

👓 Say goodbye to reading glasses! Scientists created eye drops that can restore near vision in just 1 hour.

The new eye drop therapy may soon revolutionize how we treat age-related vision loss — no glasses or surgery required.

Presented at the European Society of Cataract and Refractive Surgeons’ 2025 Congress, a large study involving 766 patients found that specially formulated drops combining pilocarpine and diclofenac can dramatically improve near vision in people with presbyopia.

Participants reported noticeable improvements just one hour after the first dose, with benefits lasting up to two years. Depending on the severity of presbyopia, most patients gained the ability to read two to three extra lines on the Jaeger chart, a standard vision test — all with only mild and temporary side effects.

The drops work by adjusting the eye’s focus and reducing inflammation, offering a non-invasive alternative for patients who struggle with glasses or aren’t suitable for surgery. While the study is limited by its single-center, retrospective design, the results are striking: over 80% of patients maintained functional near vision after a year, and no one discontinued use due to side effects.

This marks the first clinical evaluation comparing multiple pilocarpine concentrations in combination with diclofenac. Though further multi-center studies are needed to confirm long-term safety, the findings suggest these eye drops could become a convenient, accessible solution for millions dealing with age-related vision decline.

Reference: Abstract number: ESCRS25-FP-3944, ‘Dose-dependent efficacy and safety of pilocarpine-diclofenac eye drops for presbyopia: a real-world single-center study’ by Giovanna Benozzi et al., presented at the 43rd Congress of the European Society of Cataract and Refractive Surgeons.

18/09/2025

UK Scientists Achieve Breakthrough in Reversing Skin Cell Aging by 30 Years

Researchers at the Babraham Institute in the UK have made a groundbreaking discovery, rejuvenating 53-year-old human skin cells to function as if they were 23 years old, while preserving their original identity.

Using a technique called partial cellular reprogramming, they applied a brief, controlled dose of Yamanaka factors—proteins that reset the genetic markers of aging—over just 13 days.

Unlike full reprogramming, which turns cells into stem cells and erases their specialized roles, this method kept the cells’ skin-specific functions intact.

The revitalized cells exhibited remarkable changes: faster wound healing, increased collagen production, and activation of youthful gene patterns.

Visually, they appeared younger under a microscope, with improved structure, stronger connections, and enhanced resilience.

Notably, these rejuvenated traits persisted weeks after the treatment, indicating a deep, lasting reset of the cells’ biological age.

This advancement holds transformative potential for regenerative medicine, with applications for aging skin, arthritis, and possibly neurodegenerative diseases like Alzheimer’s.

The discovery paves the way for therapies that don’t just mask aging but fundamentally reverse it at the cellular level.

18/09/2025

Men’s brains may produce significantly more serotonin than women’s.

A recent study has revealed a fascinating difference in the way male and female brains regulate mood. According to researchers, men’s brains produce roughly 52% more serotonin, the neurotransmitter often called the “happiness chemical” than women’s. This discovery sheds light on why men and women can experience mood, stress, and emotional responses differently.

Serotonin plays a critical role in regulating mood, sleep, appetite, and even memory. Higher levels in the brain are generally associated with feelings of well-being and stability, while lower levels are linked to anxiety, depression, and sleep disturbances. Scientists suggest that this natural variation may partially explain why certain mental health conditions, such as depression and anxiety, are more prevalent in women than men.

It’s important to note that this doesn’t mean men are inherently happier or immune to mental health challenges. Brain chemistry is influenced by a multitude of factors including genetics, environment, lifestyle, and hormones. Still, understanding these differences could lead to more personalised approaches in mental health treatment, helping doctors create therapies better tailored to men and women.

The study also highlights the incredible complexity of the human brain. Even small differences in neurotransmitter production can have wide-ranging effects on behaviour, cognition, and emotional resilience. By exploring these nuances, scientists are learning how to fine-tune treatments for mood disorders, improve mental health outcomes, and enhance overall well-being.

This discovery reminds us that our brains are as unique as we are. Differences in chemistry don’t just shape our experiences, they offer new pathways to understanding ourselves and developing better ways to support mental health for everyone.

18/09/2025

Researchers in São Paulo have presented a groundbreaking new drug believed to be capable of reversing spinal cord injuries, offering hope to millions living with paralysis. The treatment works by stimulating nerve regeneration and repairing damaged neural connections, something previously thought impossible. Early studies in animals and limited human trials have shown promising results, with patients regaining partial mobility and sensation. Scientists say larger clinical trials are now underway, marking a potential revolution in neuroregenerative medicine.

12/09/2025

Exercise is one of the best things you can do for your health, but when taken to extremes, it can backfire. Intense workouts push your muscles beyond their natural limits, and while some stress is necessary for growth, too much stress leads to microscopic tears that take longer to heal. Normally, small tears in muscle fibers are a good thing — your body repairs them stronger than before, which is how muscle growth happens. But if you overtrain, the tears become larger and more frequent, overwhelming your body’s ability to repair them.

When you don’t give your muscles enough time to recover, scar tissue may form instead of healthy new muscle fibers. This not only reduces strength but also increases the chance of repeated injuries. Overtraining also puts strain on your joints, tendons, and ligaments, making them more vulnerable to sprains and chronic pain.

The problem isn’t just in the muscles. Excessive exercise affects the whole body. Your immune system can weaken, making you more likely to get sick. Hormonal balance shifts, increasing cortisol (the stress hormone), which can leave you feeling constantly tired, moody, and unable to sleep properly. Instead of building endurance, you may feel drained, sore, and mentally burnt out.

Warning signs of overtraining often show up as constant muscle soreness that does not improve with rest, unusual fatigue and low energy even after getting enough sleep, and difficulty sleeping or waking up during the night. You may also notice irritability, mood swings, or feeling mentally drained, along with a decline in performance despite pushing harder. More frequent injuries or persistent joint pain are also clear signals that your body is being pushed beyond healthy limits.

12/09/2025

🚨 Breakthrough in Autism Research 🚨

🧠 Stanford scientists have identified a hidden brain “gatekeeper” that could hold the key to reversing autism symptoms.

Researchers found that the reticular thalamic nucleus—a region controlling sensory input—was hyperactive in mice with autism-like traits. By dialing down this overactivity with a seizure drug and brain modulation, they restored normal behavior.

When the same region was overstimulated in healthy mice, they developed autism-like behaviors—highlighting its pivotal role. This may also explain why epilepsy so often overlaps with autism.

⚡ Still early-stage, but if confirmed in humans, this could pave the way for precise, biology-driven autism treatments.

10/09/2025

Russia has announced a breakthrough in cancer research with its new mRNA-based vaccine, Enteromix, showing 100% success in early trials. The vaccine was tested on 48 colorectal cancer patients and reportedly helped shrink tumors without major side effects.

Enteromix is developed by Russia’s National Medical Research Radiological Centre along with the Engelhardt Institute of Molecular Biology. It works like COVID mRNA vaccines, training the immune system to target each patient’s unique tumor profile.

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10/09/2025

Researchers at Monash University in Melbourne, Australia, have created the world’s first bionic eye, called the "Gennaris Bionic Vision System". This revolutionary technology is designed to restore sight by bypassing damaged optic nerves and sending visual information directly to the brain’s visual cortex.

The system includes a small camera attached to specially designed headgear, a vision processing unit, and up to 11 wireless implants placed on the brain’s surface. These implants generate patterned electrical signals that allow users to interpret visual input.

After promising results in animal trials, the device is now moving toward human clinical trials in Melbourne, bringing renewed hope to people living with currently untreatable forms of blindness.

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