17/11/2025
Recognized Causes of GERD-Like Symptoms (True Mimickers)
1. Esophageal Causes
These are the most clinically recognized mimickers.
• Eosinophilic esophagitis (EoE)
• Achalasia
• Diffuse esophageal spasm
• Hypercontractile (Jackhammer
• Esophageal hypersensitivity
• Functional heartburn
• Esophageal strictures (peptic, caustic, radiation)
• Schatzki ring
• Zenker diverticulum
• Pill-induced esophagitis (doxycycline, bisphosphonates, KCl)
• Infectious esophagitis (Candida, CMV, HSV)
• Esophageal carcinoma
• Rumination syndrome
2. Gastric / Duodenal Causes
All officially known to produce “reflux-type” discomfort.
• Peptic ulcer disease (PUD)
• Functional dyspepsia
• Gastroparesis (diabetic, postsurgical)
• Bile reflux gastritis
• Gastric outlet obstruction
• Helicobacter pylori gastritis
3. ENT–Respiratory Causes
Recognized because they often present first as “heartburn/cough.”
• Chronic sinusitis / post-nasal drip
• Asthma (classic or cough-variant)
• Upper airway cough syndrome (UACS)
• Vocal cord dysfunction (inducible laryngeal obstruction)
• Chronic laryngitis unrelated to acid
• Tracheomalacia
4. Cardiac Causes
These are critical recognized mimickers because they can kill if misdiagnosed.
• Atypical angina
• Myocardial ischemia / ACS
• Pericarditis
• Aortic dissection (rare but can present like tearing chest/epigastric pain)
5. Hepatobiliary & Pancreatic Causes
Also officially known to produce epigastric/chest burning.
• Biliary colic / cholelithiasis
• Chronic cholecystitis
• Acute pancreatitis
• Chronic pancreatitis
6. Medication-Induced Causes
Very well recognized in guidelines.
• NSAIDs
• Bisphosphonates (alendronate, risedronate)
• Doxycycline
• Potassium chloride
• CCBs (nifedipine, amlodipine)
• Nitrates
• Theophylline
• Anticholinergics
• GLP-1 agonists (semaglutide, liraglutide) — delayed emptying
• Iron tablets
• Opioids — gastric stasis
7. Systemic / Other Recognized Causes
• Anxiety / panic attacks
• Pregnancy
• Obesity (functional reflux symptoms)
• Food intolerances (lactose, FODMAPs)
• Hiatal hernia symptoms WITHOUT acid reflux
• Diabetic autonomic neuropathy (slowed motility)