12/09/2025
🌟 Ocular Drug Administration Routes 🌟
Ocular drug administration refers to the different ways medicines are delivered to the eye for treating various diseases. The route depends on the site of disease, severity, and type of medicine.
🔹 1. Topical Route (Most Common)
Forms: Eye drops, ointments, gels, sprays
Uses: Conjunctivitis, dry eye, corneal infections, glaucoma
Advantages: Easy to use, non-invasive, rapid action on anterior segment
Limitations: Poor absorption into deeper structures, frequent dosing needed.
🔹 2. Local Injections
Used when higher drug concentration is required inside the eye.
Subconjunctival Injection: Injected under conjunctiva → used for severe infections/inflammation
Intracameral Injection: Given directly into anterior chamber → used during cataract or glaucoma surgery
Intravitreal Injection: Injected into vitreous → for retinal diseases (e.g., diabetic retinopathy, ARMD, endophthalmitis)
Peribulbar / Retrobulbar Injection: For anesthesia or drug delivery around/behind the eyeball.
🔹 3. Systemic Route
Forms: Oral tablets, Intravenous (IV) injections
Uses: Severe eye infections (endophthalmitis), uveitis, orbital cellulitis
Advantages: Effective for posterior segment diseases or when local therapy is not enough
Limitations: More side effects compared to local use
🔹 4. Implants & Advanced Drug Delivery
Sustained-release Implants: Placed inside the eye to provide long-term drug delivery (e.g., intravitreal implants for macular edema)
Nanotechnology-based delivery systems: Under research for improved absorption & reduced side effects.
✅ Summary:
Topical → For anterior eye diseases
Injections → For severe infections/retinal diseases
Systemic → For deep or severe conditions
Implants → For long-term sustained release
👁️ Correct route selection is vital for effective treatment, safety, and better patient outcomes
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