11/12/2025
Just published in NEJM 🔥
Complex Regional Pain Syndrome
📘 Goebel (2025), https://www.nejm.org/doi/full/10.1056/NEJMcp2415752
👉 Complex regional pain syndrome (CRPS) is a rare post-traumatic chronic pain condition that affects a distal limb and is classified in the International Classification of Diseases, 11th Revision, as “chronic primary pain”; the condition may be autoimmune mediated.
👉 CRPS is diagnosed according to the Budapest criteria, which require the presence of objective limb abnormalities in two of four categories: sensory, vasomotor, edema or sudomotor, and motor or trophic.
👉 Approximately 80% of patients have substantial improvement within 18 months after disease onset;later improvement is rare.
👉Patient information should emphasize the nerve-function–related cause of CRPS that explains the relentless pain despite no or minor tissue change.
👉 Rehabilitative treatment with CRPS-specific physical and occupational therapy is key to improving function in the impaired limb.
👉 Treatment with simple analgesic drugs, tricyclic agents, and serotonin–norepinephrine reuptake inhibitors may improve quality of life but will typically incompletely reduce pain. Multidisciplinary pain-management treatment that follows the principles of cognitive behavioral therapy and spinal cord stimulator treatment — in persistent CRPS — can be offered at specialist centers.
📷 Illustration: . Pain Mechanisms. Shown are the mechanisms of nociceptive pain (Panel A), neuropathic pain (Panel B), and nociplastic pain (Panel C). CRPS itself is considered (mostly) nociplastic pain.