Central European Journal of Immunology

29/04/2025

🌍🔬 Today we celebrate World Immunology Day! 🔬🌍

At the Central European Journal of Immunology, we believe that immunology changes lives — by advancing medicine, improving public health, and bringing hope for better treatments and cures.

On this special day, we want to thank all immunologists, researchers, clinicians, and students who work tirelessly to unlock the secrets of the immune system. 🧠🧬
Your dedication makes a difference — every discovery, every publication, every breakthrough matters!

Let’s continue to inspire, educate, and innovate together.
Happy World Immunology Day! 🎉

👉 Follow us for the latest in immunology research!
https://www.termedia.pl/Journal/Central_European_Journal_of_nbsp_Immunology-10

05/02/2025

🔬📢 Explore the Latest Review Papers! 🧬🛡️

We are excited to share a new collection of review articles recently published in the Central European Journal of Immunology! These articles provide in-depth insights into key topics in immunology, from T-cell subpopulations to immunotherapy in esophageal cancer.

✅ Rethinking T-cell classifications – New insights into T-lymphocyte subpopulations.

by F. Lewandowski, P. Niedźwiedzka-Rystwej
DOI : https://doi.org/10.5114/ceji.2024.144071

✅ Genetic causes of primary immunodeficiency – A novel IL2RG gene mutation case report.

by: F. Cao, Y. Shi, F. Deng, Y. Yan
DOI : https://doi.org/10.5114/ceji.2024.142340

✅ Eosinophilia classification challenges – A review of eosinophil-related disorders.

by: A. Szymczyk, J. Jaworski, M. Podhorecka
DOI: https://doi.org/10.5114/ceji.2024.136512

✅ Mesenchymal stem cells & perianal fistulas – Long-term efficacy insights.

by: T. Wang, M. Li, H. Shang, L. Zou, F. Shang
DOI : https://doi.org/10.5114/ceji.2024.144866

✅ Immunotherapy in esophageal cancer – The role of PD-L1 expression.

by: J. Yao, X. Tan, Y. Sha, Y. Chen, R. Chen, D. Shi
DOI : https://doi.org/10.5114/ceji.2024.139269

✅ H. pylori & anti-TNF agents in IBD – Immunological interactions explored.

by: H. Huang, C. Gan, Y. Cai, L. Wu
DOI : https://doi.org/10.5114/ceji.2024.136376

✅ HIF-1’s role in rheumatoid arthritis – Understanding its pathogenesis and regulation.

by: H. Li, Q-Y Wu, X-H Teng, Z-P Li, M-T Zhu, C-J Gu, B-J Chen, Q-Q Xie, X-J Luo
DOI : https://doi.org/10.5114/ceji.2023.134217

🔗 Access the full collection in CEJI and stay up to date with the latest immunology research!

24/01/2025

🌟 The latest issue of the Central European Journal of Immunology (CEJI) is now online! 🌟

💡🔬 Explore Volume 49, Issue 4 (2024), featuring interesting research and discoveries in immunology.

📌 Articles in this issue:
1. LncRNA GAS5 regulates the inflammatory response in inflammatory bowel disease via targeting the miR-23a-3p/BVES axis
Authors: Fang Tong, Rui Wang, Zhuofan Wei, Sheng Xu
📄 https://doi.org/10.5114/ceji.2024.145007
2. LncRNA SNHG16 promotes LPS-induced human bronchial epithelial cell pyroptosis through miR-339-5p/NLRP1 axis mediation
Authors: Hui Liu, Jinhua Qin, Liang Deng, Jin Liu
📄 https://doi.org/10.5114/ceji.2024.145876
3. LncRNA RMRP promotes chondrocyte injury by regulating the FOXC1/RBP4 axis
Authors: Jingyi Li, Gang Zhou, Te Chen, Qiao Lin, Qiupeng Yang
📄 https://doi.org/10.5114/ceji.2024.145312
4. Predictive value of miR-582-5p for onset of sepsis-induced acute kidney injury and its functional role during disease development
Authors: Yuhong Zhao, Yuan Li, Mei Su, Xiaoyue Cai
📄 https://doi.org/10.5114/ceji.2024.145730
5. The N6-methyladenosine pattern of MAP3K7 mediates the effects of sevoflurane on macrophage M2 polarization and cervical cancer migration and invasion
Authors: Luxin Huang, Feng Duan, Xianning D**g, Zengzhen Zhang
📄 https://doi.org/10.5114/ceji.2024.145307

6. 🔎 Editor’s Pick:
Interleukin 17A promotes glycolysis to activate human hepatic stellate cells by mediating the TRAF2/TRAF5/HuR/PFKFB3 axis
Authors: Tao Jiang, Shuangjie Li, Lian Tang, Yanfang Tan, Wenxian Ouyang
📄 https://doi.org/10.5114/ceji.2024.145013

7. Swertiamarin ameliorates cognitive dysfunction by improving hyperglycemia and neuroinflammation in type 2 diabetic rats via activation of the PI3K/AKT/GSK3β signaling pathway
Authors: Bingyin Tan, Li Liu, Tao Wu, Fangjie Yuan, Cheng Wang
📄 https://doi.org/10.5114/ceji.2024.145754

💬 Letters to the Editor:
1. Familial clustering of SAPHO syndrome
Authors: Mengjiao Gu, Zixiang Zheng, Chen Zhang, Yuru Zhang, Yuanhao Wu, Chen Li
📄 https://doi.org/10.5114/ceji.2024.145732
2. Differential diagnosis of eosinophilic esophagitis variants and biomarker identification: current progress
Authors: Bartosz Hanczaruk, Aleksandra Roszko, Kamil Kamiński, Marlena Tynecka
📄 https://doi.org/10.5114/ceji.2024.143996

🔎 Editor’s Pick Editorial:
👉 The pivotal role of IL-17A in hepatic stellate cell activation
Authors: Agata Poniewierska-Baran, Jacek Tabarkiewicz, Urszula Radzikowska, Marlena Tynecka, Andrzej Eljaszewicz
📄 https://doi.org/10.5114/ceji.2024.146900

📰 Dive into all the articles and share your feedback with the immunology community!
🔗 https://www.termedia.pl/Journal/Central_European_Journal_of_nbsp_Immunology-10
💡🔬 Let’s continue advancing immunology together! 💡🔬

16/01/2025

🔬 Have you seen CEJI Issue 3/2024?! 📖

We are excited to present the latest issue of the Central European Journal of Immunology (CEJI), packed with 6 Original Papers, 3 Review Articles, and 1 Case Report—offering a wealth of knowledge for researchers and clinicians alike!

✨ Editor’s Pick:
How BATF silencing protects neonatal lungs in sepsis
Eliza Glodkowska-Mrowka, Marlena Tynecka, Andrzej Eljaszewicz
📄 Read more: https://doi.org/10.5114/ceji.2024.145408

🔬 Other Articles in This Issue:
1️. LncRNA HCP5 as a Potential Diagnostic Biomarker and Regulator of Inflammatory Response in Neonatal Sepsis
Xiaohua Hu, Anhui Hu, Yong Luo, Shuisheng Yuan, Lei Yang
📖 https://doi.org/10.5114/ceji.2024.143462

2️. LncRNA DLEU1 Contributes to the Progression of Septic Myocardial Dysfunction by Targeting miR-381-3p
Tian Tian, Na Zhang, Guoxin Hu, Rong Lu, Jian Liu
📖 https://doi.org/10.5114/ceji.2024.144199

3️. Knockdown of BATF Alleviates Lung Injury in Septic Neonates Through Transcriptional Regulation of COTL1
Jihui Zhang, Huimin Jiang
📖 https://doi.org/10.5114/ceji.2024.144865

4️. Down-Regulation of SHP2 Promotes Neutrophil Autophagy and Inhibits Neutrophil Extracellular Trap Formation to Alleviate Asthma Through the ERK5 Pathway
Dandan Shi, Jian Huang, Jie Wu
📖 DOI: 10.5114/ceji.2024.143691

5️. Long-Term Efficacy of Mesenchymal Stem Cell Treatment for Complex Perianal Fistulas: A Systematic Review and Meta-Analysis
Tao Wang, Min Li, Hua Shang, Lei Zou, Feng Shang
📖 DOI: 10.5114/ceji.2024.144866

6️. Enhanced Immune Regulation in the U937 Inflammation Model Using MSC-Derived Extracellular Vesicles Stimulated by Pro-Inflammatory Cytokines
Canan Öztürk, Zehra S. Halbutoğullari
📖 DOI: 10.5114/ceji.2024.143726

7️. Novel IL2RG Gene Mutation Causing Primary Combined Immunodeficiency Disease: A Case Report and Literature Review
Fang Cao, Yingyu Shi, Fang Deng, Yu Yan
📖 DOI: 10.5114/ceji.2024.142340

8️. New T-Lymphocyte Subpopulations and Their Characteristics: Challenges to the Classical Division of Lymphocyte Function
Filip Lewandowski, Paulina Niedźwiedzka-Rystwej
📖 DOI: 10.5114/ceji.2024.144071

9️. Systemic Lupus Erythematosus in a Patient With 22q11.2 Deletion Syndrome: A Case Report and Literature Review
Chen Sun, Pingyang Han, Juzhen Yan
📖 DOI: 10.5114/ceji.2024.143229

10. STK11 Mutation Affects Tumor Proliferation by Impacting CD4+ T Cell Activity in Lung Adenocarcinoma
Jiemeng Ge, Rui Feng, Feihu Zhu, Zhihui Xu, Qiangwei Chi, Zhenye Lv
📖 DOI: 10.5114/ceji.2024.143578

📚 Explore the full issue here: https://www.termedia.pl/Journal/Central_European_Journal_of_nbsp_Immunology-10

Let’s continue advancing immunology together! 💡🔬

07/10/2024

‼️The Nobel Prize in Physiology or Medicine 2024 was announced! ‼️
👏👏👏👏👏👏👏👏

BREAKING NEWS
The Nobel Assembly at the Karolinska Institutet has today decided to award the 2024 Nobel Prize in Physiology or Medicine to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

This year’s Nobel Prize honours two scientists for their discovery of a fundamental principle governing how gene activity is regulated.

The information stored within our chromosomes can be likened to an instruction manual for all cells in our body. Every cell contains the same chromosomes, so every cell contains exactly the same set of genes and exactly the same set of instructions. Yet, different cell types, such as muscle and nerve cells, have very distinct characteristics. How do these differences arise? The answer lies in gene regulation, which allows each cell to select only the relevant instructions. This ensures that only the correct set of genes is active in each cell type.

This year’s medicine laureates Victor Ambros and Gary Ruvkun were interested in how different cell types develop. They discovered microRNA, a new class of tiny RNA molecules that play a crucial role in gene regulation. Their groundbreaking discovery revealed a completely new principle of gene regulation that turned out to be essential for multicellular organisms, including humans. It is now known that the human genome codes for over one thousand microRNAs. Their surprising discovery revealed an entirely new dimension to gene regulation. MicroRNAs are proving to be fundamentally important for how organisms develop and function.

Learn more
Press release: https://bit.ly/3BiM2o9
Advanced information: https://bit.ly/3N6vAtK

25/09/2024

Celebrating World Lung Day held on the 25th of September 2024, we would like to remind you of the recent papers published in our Journal European Journal of Immunology

1. Hemn Abdalla Omer , Christer Janson, Kawa Amin
The role of inflammatory and remodeling biomarkers in patients with non-small cell lung cancer
DOI: https://doi.org/10.5114/ceji.2023.133725

2. Kosar M. Ali, Nsar Jamal, Shukur Wasman Smail et al.,
Biomarkers of type 2 and non-type 2 inflammation in asthma exacerbations
DOI: https://doi.org/10.5114/ceji.2024.141345

3. Xiaozhen Cai, Rong Rong, Yidan Huang et al.,
Effects of theophylline combined with inhaled corticosteroids on patients with moderate and severe asthma and changes of T lymphocyte subsets in peripheral blood
DOI: https://doi.org/10.5114/ceji.2023.127843

4. Jarosław Bakiera , Karolina Strzelec-Pawełczak, Katarzyna Czarnek et al.,
Novel inflammatory markers in patients with severe COVID-19 and a pulmonary thrombotic event
DOI: https://doi.org/10.5114/ceji.2023.131382

5. Jarosław Bakiera , Cezary Grochowski, Karolina Strzelec-Pawełczak et al.
The analysis of Fe-dependent serum enzymes in severe COVID-19 with a pulmonary thrombotic event
DOI: https://doi.org/10.5114/ceji.2022.124076

6. Ieva Vanaga , Oksana Kolesova, Aleksandrs Kolesovs et al.,
Association of human leukocyte antigen class II alleles with epithelial cell apoptosis and extracellular matrix production in acute COVID-19
DOI: https://doi.org/10.5114/ceji.2023.133684

7. Shuang Qin, Ruiqi Chen , Meihui Li et al.,
Changes in immune status of circulating NK cells in patients with latent tuberculosis infection
DOI: https://doi.org/10.5114/ceji.2024.142104

8. Spaska Lesichkova, Snezhina Mihailova, Elisaveta Naumova et al.,
Mild to moderate clinical course of Covid-19 infection in patients with CVID
DOI: https://doi.org/10.5114/ceji.2022.124079

For more published research, please visit the CEJI website: https://www.termedia.pl/Journal/Central_European_Journal_of_nbsp_Immunology-10

30/08/2024

2/2024
Take a look! New Content Below!

Editor’s Pick:
Exploring the role of hyperforin in modulating the NF-κB/miR-21 axis in sepsis-induced acute kidney injury
Paulina Niedźwiedzka-Rystwej, Dorota Siwicka, Andrzej Eljaszewicz


Letter to the Editor:
A case of trigeminal neuralgia that occurred after COVID-19 vaccination
Zeliha Ünlü, İlhan Celil Özbek


Technical Report
Comparison of cytotoxicity methods for studying Vipera ammodytes venom and the anticytotoxic potency of antivenom
Ivana Lukic, Veljko Blagojevic, Rajna Minic, Sasa Ivanovic, Suncica Borozan, Vitomir Cupic, Irena Zivkovic

Clinical Immunology:
Changes in immune status of circulating NK cells in patients with latent tuberculosis infection
Shuang Qin, Ruiqi Chen, Meihui Li, Jiangfeng Lv, Fengmei Zhang, Yuguo Ren, Xiangyang Lin

Basic Immunology:
Apurinic/apyrimidinic endonuclease 1 alleviates inflammation in fibroblast-like synoviocytes from patients with rheumatoid arthritis
Ha-Reum Lee, Su-Jin Yoo, Jinhyun Kim, Yu Ran Lee, Hee Kyoung Joo, Byeong Hwa Jeon, Seong Wook Kang

Clinical Immunology:
Risk factors of thyroid dysfunction in patients with rheumatoid arthritis
Lan Li, Fuda Jiao, Jinmei Zhao, Lizhi Duan

Clinical Immunology:
Targeting the serum marker interleukin 9 improves the underlying characterization and immune homeostasis in rheumatoid arthritis
Ying Xiong, Wang Xiang, Wei Xiao

Clinical Immunology:
Progression patterns in patients with advanced hepatocellular carcinoma treated with local therapy, targeted drugs, and PD-1/PD-L1 inhibitors
Yanan Zhao, Di Wu, Quanjun Yao, Hang Yuan, Hongtao Hu, Hailiang Li

Clinical Immunology:
CSF3R as a potential prognostic biomarker and immunotherapy target in glioma
Minglei Huang, Longze Zhang, Yan Wu, Xue Zhou, Yanyang Wang, Jidong Zhang, Ye Liu, Zhixu He, Xianyao Wang

Basic Immunology:
Preventive effect of hyperforin on lipopolysaccharide-induced acute kidney injury and inflammation by repressing the NF-κB/miR-21 axis
Haozhe Fan, Xiao He, Hongjie Tong, Kun Chen

Clinical Immunology:
The effect of periodontal health and disease on interleukin 1β and nesfatin-1 levels in gingival crevicular fluid: A cross-sectional study
Meral Uzunkaya, Eda Çetin Özdemir, Hasan Gündoğar, Ergül Belge Kurutaş

Basic Immunology:
Transcriptome analysis of anaerobic glycolysis effects on Jurkat T cell proliferation
Ziyu Wang, Hongyang Wang, Qinghai Wang, Tao Huang, Chen Guo, Jianlei Ji, Meijie Su, Weijia Xu, Yanwei Cao, Zhen D**g

Clinical Immunology:
Biomarkers of type 2 and non-type 2 inflammation in asthma exacerbations
Kosar M. Ali, Nsar Jamal, Shukur Wasman Smail, Martin Lauran, Jonas Bystrom, Christer Janson, Kawa Amin

Visit:
https://www.termedia.pl/Journal/Central_European_Journal_of_nbsp_Immunology-10

06/08/2024

Meet the CEJI Associated Editor

Eliza Glodkowska-Mrowka, MD PhD

Dr Glodkowska-Mrowka combines clinical responsibilities with strong expertise in basic and translational hematology and immunohematology. Her research interests focus on treatment resistance mechanisms in leukemias, diagnostics in hematology and immunology, and regulation of hematopoiesis. She graduated as a medical doctor from the Medical University of Warsaw (MUW). Following her Ph.D. studies at the Department of Immunology, MUW, she received a 4-year postdoctoral fellowship at the University of Copenhagen (Denmark) to pursue her research goals in leukemia development and normal and malignant hematopoiesis regulation. Next, she joined the Institute of Hematology and Transfusion Medicine in Warsaw, initially as a PI at the Department of Experimental Hematology and next as a research group leader and the head of the Department of Immunohematology. Her academic achievements were recognized by the Ministry of Science and Higher Education Scholarship for Outstanding Young Scientists, the Polish Ministry of Health Award for the most recognized publication, and several other international and national awards and fellowships. She received several research scholarships, including visiting scholarships at the University of Ulm, Germany, and Temple University, Philadelphia, PA, USA. She is a leader of several basic and clinical research grants, including a Medical Research Agency grant for conducting noncommercial clinical trials. She serves as an external expert for the European Commission and Council of Europe, as well as an editorial board member of several journals focused on hematology.

15/07/2024

Meet the CEJI Associated Editor

Prof. Jacek Tabarkiewicz M.D., Ph.D.

Prof. Tabarkiewicz graduated with a degree from the medical school of the Medical Academy in Lublin, where he continued his professional career at the Department of Clinical Immunology. Since 2010, he has been associated with the University Rzeszów, where he held the position in 2015-2019 as the function of Director of the Center for Innovative Research Natural and Medical Sciences. He serves as the head of the Department of Human Immunology and head of the Laboratory of Research Translational in Medicine. He is a member of the Management Board Polish Society of Cytometry, a member of the Polish Society of Experimental and Clinical Immunology, former member International Society for Dendritic Cell & Vaccine Science. He held the position of Associate Editor in the Journal of Immunology Research and senior member of the editorial board of the American Journal of Cancer Therapy and Pharmacology; member of the World Editorial Board Journal of Respirology and SciTz Gynecology and Reproductive Medicine, as well as the editor of the Immunology and experimental therapies section European Journal of Clinical and Experimental Medicine. He was the principal investigator in many scientific grants. Laureate of team award of the Minister of Health and numerous awards of Rector of the Medical University of Lublin and Rector University of Rzeszów for scientific and teaching achievements. The total scientific achievements include 189 publications (with a total IF = 309,221.849, score of the KBN/MNiSW/MEiN = 4734; number of citations 1805 and Hirsch Index = 22 according to. Scopus database and 1573 and Hirsch Index = 21 according to Web of Science. He is the author or co-author of over 150 abstracts of national or international conferences. The main strand of his research is pathogenesis autoimmune diseases and cancer immunology. He was a member of the scientific team conducting phase I-III non-commercial and commercial clinical trials. He is working as a physician at the 2nd Department of Pediatrics and Endocrinology Pediatric Diabetology focusing on therapy of childhood autoimmune diseases and fibrodysplasia ossificans progressiva (FOP).

09/07/2024

Meet the CEJI Associated Editor

Dorota Siwicka-Gieroba, PhD

Dorota Siwicka Gieroba is a specialist in `Anesthesiology and Intensive Care, working in a large Clinical Hospital and Trauma Center in Lublin. In addition, She has been actively working scientifically for several years. After graduating from University in 2011, She started PhD study in the Clinical Immunology Department in Lublin. After her PhD dissertation actively started clinical research focusing on cardiac and lung complications after severe brain injury in intensive care patients. Dorota Siwicka Gieroba received numerous scholarships, including the European Society of Anesthesiology and Intensive Care. She was the winner and participant of the European Trainee Exchange Programme in 2018. Her scientific focus is intensive care medicine, acute respiratory failure, mechanical ventilation, brain injury, TBI, brain-organ crosstalk, and clinical immunology, especially in critical care.

26/06/2024

Good news from JCR...
The 2024 JCR Impact Factor was released!!! Our new IF = 1.5

18/06/2024

Meet the CEJI Associated Editor

Prof. Andrzej Siwicki, PhD

Immunologist, virologist, organizer, and over 25 years head of the Department of Microbiology and Clinical Immunology FVM University of Warmia and Mazury in Olsztyn published more than 700 publications with IF. H-index over 30. Main research directions: comparative and developmental immunology, immunotoxicology, immunomodulation, infectious immunology. Significant achievements: the effect of environmental contamination on defense mechanisms and anti-infective immunity, correction of impaired immunity using natural and synthetic immunomodulators, and the impact of environmental contamination on vaccine effectiveness. Recent years of research have included the application of nanotechnology in clinical immunology, the isolation and identification of virophages, the possibility of using them in the therapy of viral infections, and the application of bacteriophages in targeted therapy. Member of the New York Academy of Sciences, FAO/WHO expert, nominated twice to the Stanford list, supervisor/promoter of 22 PhD dissertations. He has carried out 24 scientific missions to Vietnam, Japan, the USA, the Netherlands, Israel, and France and led 13 international scientific projects.