Advances in Clinical and Experimental Medicine

Advances in Clinical and Experimental Medicine 5-Year IF 2.0, IF 1.9, JCI (2024) 0.43, Scopus CiteScore 4.3, H-index 49 (SJR)
Initial editorial assessment and first decision within 24 h

📢New call for submissions 📢📢 Innovations in Therapeutic Interventions: Advancing Clinical and Experimental Medicine 📢Han...
11/01/2026

📢New call for submissions 📢

📢 Innovations in Therapeutic Interventions: Advancing Clinical and Experimental Medicine 📢

Handling Editors

Dr. Masaru Tanaka (ELKH-SZTE Neuroscience Research Group, Eötvös Loránd Research Network, University of Szeged (ELKH-SZTE), Hungary)
Dr. Simone Battaglia (Center for Studies and Research in Cognitive Neuroscience, Department of Psychology, University of Bologna, Italy
Dr. Francesco Di Gregorio (AUSL Bologna; Department of Psychology, University of Bologna, Italy)
Prof. Izabella Uchmanowicz (Wroclaw Medical University, Poland)
Prof. Donata Kurpas (Wroclaw Medical University, Poland)

We welcome reviews as well as original research articles and research letters in various clinical and experimental medicine areas. We encourage submissions on the following topics:

Precision Medicine and Personalized Therapies: Explore novel approaches in tailoring medical treatments based on an individual's genetic makeup, environmental factors, and disease characteristics. Highlight the potential of precision medicine in improving patient outcomes and overcoming treatment challenges. This topic includes but is not limited to:

a) Immunotherapy and Immunomodulation: Investigate the role of immunotherapy and immunomodulation in treating various diseases, including cancer, autoimmune disorders, and infectious diseases. Focus on cutting-edge techniques, therapeutic targets and potential synergies with other treatment modalities.
b) Gene and Cell Therapies: Present innovative research on gene and cell-based therapies, such as stem cell transplantation, gene editing and regenerative medicine. Explore their applications across different diseases and discuss their clinical implications and prospects.

The paper can also encompass:
Artificial Intelligence and Big Data Analytics in Medicine: Examine the integration of artificial intelligence (AI) and big data analytics in medical research, diagnostics, treatment optimization, and patient care. Highlight the potential of AI algorithms, machine learning and data-driven approaches in revolutionizing healthcare practices.
Digital Health Technologies and Wearables: Discuss the advancements in digital health technologies (including telemedicine), wearable devices and remote monitoring systems. Explore their impact on healthcare delivery, patient engagement, disease management, and prevention strategies.

All papers should focus on:
Translational Research and Bench-to-Bedside Innovations: Showcase translational research efforts that bridge the gap between laboratory discoveries and clinical applications. Present successful examples of bench-to-bedside innovations that have improved patient care and outcomes.

Keywords
therapeutic interventions; personalized therapies; immunotherapy; immunomodulation; gene and cell therapies; artificial intelligence; Big Data analytics; digital health technologies

By submitting your research to Adv Clin Exp Med, you will become an integral part of a dynamic and vibrant community of dedicated researchers committed to advancing the fields of clinical and experimental medicine. By undergoing our rigorous peer-review process, you can be assured that only high-quality and impactful studies are published, enhancing your professional reputation and contributing to advancing medical knowledge.

We look forward to receiving your submissions and collaborating to make a lasting impact on the field of clinical and experimental medicine.

MORE INFORMATION
https://advances.umw.edu.pl/en/innovations

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

📢New call for submissions📢Call for Submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection o...
10/01/2026

📢New call for submissions📢

Call for Submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on Advances in Hand Surgery and Hand Therapy

The hand is a remarkably complex organ, and even minor injury or disease can severely impair its function, making precise assessment essential for accurate diagnosis, effective treatment, and successful rehabilitation.

Hand surgery combines orthopedics, plastic and reconstructive surgery, microsurgery, and traumatology. Advances in techniques, biomaterials, and regenerative medicine continue to improve outcomes and quality of life. Hand therapy – encompassing physiotherapy, occupational therapy, splinting, pain management, and patient education – plays an equally vital role in restoring fine motor skills after delicate surgical repair.

Effective management of hand conditions depends on close interdisciplinary collaboration among surgeons, therapists, and other professionals. Despite progress, challenges remain in achieving long-term functional recovery, improving patient-reported outcomes, and ensuring equitable access to care. Evidence-based healthcare (EBHC) provides the foundation for modern practice, integrating clinical expertise, research evidence, and patient values.

In recognition of these ongoing developments and collaborative efforts, this Call for Submissions accompanies the 13th Congress of the Polish Society for Surgery of the Hand and the 3rd Congress of the Polish Society for Hand Therapy, to be held in Wroclaw, Poland, on October 9–11, 2025, organized by the Polish Society for Surgery of the Hand, the Polish Society for Hand Therapy, and the Clinical Department and Department of Orthopedics, Traumatology and Hand Surgery, Faculty of Medicine, Wroclaw Medical University.

Articles submitted should address the broad field of hand surgery and hand therapy. Contributions may focus on fundamental principles of hand function, such as anatomy and biomechanics, clinical examination, functional assessment, imaging, electrodiagnostic studies, and patient-reported outcome measures, as well as modern diagnostic approaches, surgical techniques, therapeutic strategies, and interdisciplinary care.

Suggested topics include, but are not limited to, hand surgery and hand therapy in the following conditions:

Traumatic injuries: fractures, dislocations, flexor and extensor tendon injuries, nerve and vascular injuries, amputations and replantations, and complex post-traumatic reconstructions.
Degenerative and inflammatory diseases: osteoarthritis, rheumatoid arthritis, scleroderma, and other connective tissue diseases.
Neurological conditions: stroke, tetraplegia, peripheral and central neurologic diseases, and nerve compression syndromes.
Congenital and developmental disorders: congenital anomalies and deformities in children, including malformations requiring surgical correction and long-term therapy.
Metabolic and systemic disorders: diabetes-related hand conditions and other systemic metabolic diseases affecting the hand.
Burns of the hand: acute surgical treatment, reconstructive procedures, and long-term rehabilitation, including scar management, splinting, and functional recovery.
Tumors of the hand and wrist: benign and malignant tumors.
Infections: acute and chronic infections.
Vascular disorders: Raynaud’s phenomenon, ischemic conditions, and vascular insufficiency of the hand.
Iatrogenic and secondary conditions: complications after surgery, contractures, scarring, stiffness, and chronic pain syndromes.
Other common hand problems: Dupuytren’s contracture, trigger finger, ganglion cysts, and other frequently encountered conditions

MORE INFORMATION
https://advances.umw.edu.pl/en/hand-surgery-therapy



Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

🚀Ahead of print 🚀The causal role of metabolic syndrome components in insomnia: A bidirectional two-sample Mendelian rand...
09/01/2026

🚀Ahead of print 🚀

The causal role of metabolic syndrome components in insomnia: A bidirectional two-sample Mendelian randomization

➡️Genetic Evidence Links Metabolic Syndrome to Insomnia Risk. Mendelian randomization analysis revealed waist circumference and hypertension significantly increase insomnia susceptibility.

➡️Hypertension and Central Obesity Identified as Key Insomnia Risk Factors. Elevated blood pressure and larger waist circumference showed strong causal associations with sleep disturbances.

➡️No Reverse Causal Effect of Insomnia on Metabolic Traits. Reverse MR analysis found no significant genetic link between insomnia and triglycerides, HDL-C, or fasting blood glucose.

➡️Study Highlights Neuroendocrine and Metabolic Pathways in Sleep Disorders. Findings underscore the role of metabolic dysfunction in insomnia, guiding future prevention and treatment strategies.

https://advances.umw.edu.pl/en/ahead-of-print/195188/

🚀Ahead of print 🚀Risk assessment of human monkeypox infections: A systematic review and meta-analysisHighlights➡️HIV inf...
09/01/2026

🚀Ahead of print 🚀

Risk assessment of human monkeypox infections: A systematic review and meta-analysis

Highlights

➡️HIV infection significantly elevates risk of human monkeypox: Meta-analysis reveals HIV-positive individuals have more than double the risk of monkeypox infection (odds ratio (OR) = 2.21), highlighting an urgent need for targeted public health interventions.
➡️Concurrent s*xually transmitted infection (STIs) are strongly linked to higher honkeypox susceptibility: Individuals with STIs face significantly increased monkeypox risk (OR = 1.84), reinforcing the importance of integrated STI and monkeypox screening programs.
➡️Sociodemographic factors show no significant association with monkeypox risk: BMI, income, education level, and men who have s*x with men (MSM) status did not show statistically significant associations, suggesting that biological risk factors may outweigh sociodemographic ones.
➡️Systematic review supports focused prevention for vulnerable populations: Findings emphasize the need for prevention strategies targeting high-risk groups, particularly those with HIV or STIs, to curb rising global monkeypox transmission.

https://advances.umw.edu.pl/en/ahead-of-print/203099/

🚀Ahead of print🚀Clinical analysis of 338 cases of dacryolithiasis➡️Clinical Characteristics of Dacryolithiasis: Secretio...
08/01/2026

🚀Ahead of print🚀

Clinical analysis of 338 cases of dacryolithiasis

➡️Clinical Characteristics of Dacryolithiasis: Secretions as Key Diagnostic Indicator. Secretions remain the primary clinical manifestation of dacryolithiasis, complicating diagnosis and treatment planning.

➡️Surgical Success in Treating Canaliculitis and Dacryolithiasis. Canaliculotomy achieved a 98.34% cure rate for canaliculitis, while En-DCR and lacrimal intubation effectively treated dacryolithiasis and nasolacrimal duct stones.

➡️Microbial Infections Associated with Dacryolithiasis. Over 20% of canaliculitis cases tested positive for bacteria, with Staphylococcus epidermidis and Streptococcus mitis as the most common pathogens.

➡️Tailored Surgical Approaches Based on Stone Location. Canaliculotomy, En-DCR, and lacrimal intubation were applied according to stone location, ensuring high treatment success rates across 338 patients.

https://advances.umw.edu.pl/en/ahead-of-print/192223/

🚀 Ahead of print 🚀Basket trial designs in oncology: A comprehensive systematic reviewHighlights➡️Molecularly driven bask...
08/01/2026

🚀 Ahead of print 🚀

Basket trial designs in oncology: A comprehensive systematic review

Highlights

➡️Molecularly driven basket trials in oncology group patients by shared biomarkers rather than tumor origin, advancing precision medicine.
➡️Systematic review of 76 basket trials (2014–2024) reveals design trends, patient selection strategies and outcome metrics.
➡️Phase II studies dominate, with a primary focus on solid tumors, validating biomarker-guided therapeutic approaches.
➡️Average trial duration of 5.9 years and 326-patient recruitment targets highlight the scale and timelines of modern basket trials.
➡️USA-based leadership in basket-trial research – the majority of studies are conducted in the USA, showcasing regional expertise in precision oncology.

https://advances.umw.edu.pl/en/ahead-of-print/204832/

🚀 Ahead of print 🚀Psychological distress in Chinese women with benign breast disease and breast cancer during diagnosis:...
07/01/2026

🚀 Ahead of print 🚀

Psychological distress in Chinese women with benign breast disease and breast cancer during diagnosis: A cross-sectional study

Highlights

➡️Amiodarone as a leading class III antiarrhythmic agent combines antiarrhythmic and vasodilator effects but carries a risk of hepatotoxicity.
➡️Amiodarone induces severe oxidative liver damage in rats, confirmed by biochemical, histopathological, and immunohistochemical analyses.
➡️Mitochondrial dysfunction underlies hepatocyte injury, with reduced ATP content and elevated ROS levels driving oxidative stress.
➡️Exogenous ATP and resveratrol supplementation mitigate liver damage, with resveratrol enhancing intracellular ATP production.
➡️Optimizing ATP dosing or combining ATP with resveratrol may offer a protective strategy against amiodaroneinduced hepatic injury.

https://advances.umw.edu.pl/en/ahead-of-print/204102/

👥💬ACEM monthly editorial duty hour👥💬Once a month our Managing Editor, Marek Misiak, is awaiting you at a Google Meets me...
07/01/2026

👥💬ACEM monthly editorial duty hour👥💬

Once a month our Managing Editor, Marek Misiak, is awaiting you at a Google Meets meeting to answer all your questions and clarify problematic issues.

The meeting takes place on the first Thursday of each month between 9:30 and 10:30 CET. You can enter the meeting using the following URL:

meet.google.com/dqi-kzsz-fga

The only prerequisite is a Google account – without it you will not be able to log in into the meeting.

🗓️ Upcoming dates: January 8, February 5, March 5, April 2, May 5, June 11, July 2, August 6, September 3, October 1, November 5, and December 3.

🚀 Ahead of print🚀Effectiveness of sorafenib in combination with physical thermal ablation for hepatocellular carcinoma: ...
06/01/2026

🚀 Ahead of print🚀

Effectiveness of sorafenib in combination with physical thermal ablation for hepatocellular carcinoma: A meta-analysis

Highlights

➡️Sorafenib plus thermal ablation doubles survival in HCC patients: Meta-analysis of 3,341 patients shows that combining sorafenib with physical thermal ablation significantly improves overall survival (OR 2.03; p < 0.001) in hepatocellular carcinoma (HCC) treatment.
➡️Combination therapy reduces HCC recurrence risk: Sorafenib and thermal ablation together lower recurrence rates in HCC patients by 38% (OR 0.62; p = 0.04), highlighting a strong preventive benefit over ablation alone.
➡️Enhanced treatment efficacy with sorafenib-based combination strategy: Overall treatment efficacy improved significantly when sorafenib was added to thermal ablation (OR 2.53; p < 0.001), indicating superior therapeutic outcomes.
➡️Meta-analysis supports combined modality for improved HCC outcomes: Evidence from 19 studies suggests that sorafenib-ablation combination offers a powerful approach for improving prognosis in hepatocellular carcinoma, especially in high-burden regions like China.

https://advances.umw.edu.pl/en/ahead-of-print/202323/

🚀Ahead of print🚀🚀MiR-204-5p promoted maternally expressed gene 3 (MEG3) through SP1-mediated DNMT1 pathway in trophoblas...
05/01/2026

🚀Ahead of print🚀

🚀MiR-204-5p promoted maternally expressed gene 3 (MEG3) through SP1-mediated DNMT1 pathway in trophoblast cells in recurrent miscarriage🚀

➡️A novel miR-204-5p/SP1/DNMT1/MEG3 regulatory axis was identified in trophoblast cells, revealing key epigenetic mechanisms involved in recurrent miscarriage (RM).
➡️miR-204-5p enhances MEG3 expression by targeting SP1 and suppressing DNMT1-mediated DNA methylation, leading to reduced trophoblast proliferation, migration, and invasion.
➡️SP1 knockdown promotes apoptosis and decreases invasive behavior in HTR-8/SVneo cells, while DNMT1 overexpression reverses these protective effects.
➡️Findings highlight MEG3 upregulation as a protective mechanism and suggest new molecular targets for diagnosing and treating recurrent miscarriage.

https://advances.umw.edu.pl/en/ahead-of-print/195925/

🚀Ahead of print 🚀Umbelliferone inhibits proliferation and metastasis via modulating cadherin/β-catenin complex-aided cel...
05/01/2026

🚀Ahead of print 🚀

Umbelliferone inhibits proliferation and metastasis via modulating cadherin/β-catenin complex-aided cell-cell adhesion in glioblastoma cells

Glioblastoma multiforme (GBM) is the most aggressive brain tumor malignancy in adults, accounting for nearly 50% of all gliomas. Current medications for GBM frequently lead to drug resistance.
Umbelliferone (UMB) is found extensively in many plants and shows numerous pharmacological actions against inflammation, degenerative diseases and cancers. However, its anticancer effects on GBM cells have not yet been explored.

https://advances.umw.edu.pl/en/ahead-of-print/192547/

📢Out in Health: Health Equity and Innovations in LGBT+ Care📢Call for submissions of an Expression of Interest for an Adv...
04/01/2026

📢Out in Health: Health Equity and Innovations in LGBT+ Care📢

Call for submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on LGBT+ Health Equity and Innovation

Handling Editors

Assoc. Prof. Michał Czapla (Division of Scientific Research and Innovation in Emergency Medical Service, Department of Emergency Medical Service, Faculty of Nursing and Midwifery, Wroclaw Medical University, Wrocław, Poland; Group of Research in Care (GRUPAC), Faculty of Health Sciences, University of La Rioja, Logroño, Spain; ORCID 0000-0002-4245-5420) michal.czapla@umw.edu.pl

Dr. Anthony Dissen (Stockton University, Galloway, USA; ORCID 0000-0003-0828-387X) anthony.dissen@stockton.edu

This Call for Submissions invites Expressions of Interest for a Special Collection of Advances in Clinical and Experimental Medicine, focusing on LGBT+ health equity and innovation.

LGBT+ individuals around the world face unique and persistent health disparities driven by stigma, discrimination, and systemic exclusion from healthcare systems. These inequities result in significantly worse physical and mental health outcomes and limit access to inclusive, culturally competent care.

This Special Collection will offer researchers and clinicians an opportunity to publish original research, meta-analyses, and review articles that address these disparities and propose inclusive, personalized, and innovative solutions to improve health outcomes for LGBT+ populations.

This Call welcomes submissions on (but not limited to):

* Mental Health & Well-being
* Sexual & Reproductive Health
* Transgender & Gender-Diverse Health
* Equity in Healthcare Access
* Social Determinants of Health
* Stigma & Healthcare Avoidance
* Community & Public Health Initiatives
* Intersectionality in Health

MORE INFORMATION
https://advances.umw.edu.pl/en/lgbt


Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu
Dr hab. Michał Czapla

Adres

Karola Marcinkowskiego 2-6
Wroclaw
50-368

Godziny Otwarcia

Poniedziałek 08:00 - 16:00
Wtorek 08:00 - 16:00
Środa 08:00 - 16:00
Czwartek 08:00 - 16:00
Piątek 08:00 - 16:00

Telefon

+48607983232

Strona Internetowa

Ostrzeżenia

Bądź na bieżąco i daj nam wysłać e-mail, gdy Advances in Clinical and Experimental Medicine umieści wiadomości i promocje. Twój adres e-mail nie zostanie wykorzystany do żadnego innego celu i możesz zrezygnować z subskrypcji w dowolnym momencie.

Skontaktuj Się Z Praktyka

Wyślij wiadomość do Advances in Clinical and Experimental Medicine:

Skróty

Udostępnij

Share on Facebook Share on Twitter Share on LinkedIn
Share on Pinterest Share on Reddit Share via Email
Share on WhatsApp Share on Instagram Share on Telegram