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Advances in Clinical and Experimental Medicine, Karola Marcinkowskiego 2-6, Wroclaw (2026)

15/05/2026

📢New call for submissions📢

Exploring the Gut-Brain Axis, Implications for Neurological and Psychiatric Disorders – Mechanisms, Biomarkers, and Emerging Therapies

🧠The gut–brain axis represents a rapidly evolving frontier in medicine, shedding new light on how gut microbiota and their metabolites influence brain development, function, and disease. Its importance is increasingly recognized across neuroscience, psychiatry, immunology, endocrinology, and translational medicine.

🧠This special issue of Advances in Clinical and Experimental Medicine seeks to consolidate high-impact, novel research that advances our mechanistic and clinical understanding of gut–brain crosstalk, with a particular focus on its relevance for neurological and psychiatric disorders. We welcome interdisciplinary submissions that go beyond descriptive associations and offer insights into molecular mechanisms, predictive biomarkers, sex-specific effects, response to therapy, and new avenues for clinical intervention.

🧠Suggested thematic areas

➡️Microbiota and neurodevelopment: Mechanistic and clinical studies on how gut microbes influence brain development, connectivity, and vulnerability to disorders like ASD and ADHD.

➡️Gut dysbiosis in psychiatric disorders: Novel links between altered microbial composition and psychiatric conditions such as depression, anxiety, schizophrenia, and bipolar disorder.

➡️Molecular communication pathways: Exploration of immune, endocrine, vagal, and epigenetic mechanisms mediating gut–brain signaling beyond known metabolic routes.

➡️Sex-specific differences in the gut–brain axis: Studies focusing on gender-related variations in microbiota composition, signaling, and effects on neuropsychiatric trajectories.

➡️Microbiota–drug interactions: How gut microbes influence drug metabolism, therapeutic response, and treatment tolerability in psychiatric patients.

➡️AI and computational modeling: Predictive modeling of brain disorders or treatment outcomes based on microbiome and host data using artificial intelligence.

➡️COVID-19 and post-viral neuropsychiatric sequelae: Investigations into the role of gut dysbiosis in persistent cognitive and mood symptoms following COVID-19 and similar infections.

➡️Microbiome-based therapies: Evaluation of targeted interventions - such as psychobiotics, prebiotics, dietary patterns, and FMT – in mental health care.

➡️Metabolomic profiling: Identification of gut-derived bioactive compounds that modulate brain function via neurotransmitter or hormonal pathways.

➡️Gut barrier integrity and neuroinflammation: Role of increased intestinal permeability and systemic inflammation in dementia, mood disorders, and neurodegeneration.

➡️Translational and clinical studies: Implementation research, including clinical trials, safety data, treatment biomarkers, and regulatory perspectives.

🔗MORE INFORMATION: https://advances.umw.edu.pl/en/gut-brain-axis

14/05/2026

🚀Recently published🚀

Long-term safety and efficacy of loose combined cutting seton therapy for high a**l fistula: Evidence from a prospective cohort study

Highlights

➡️High a**l fistula (HAF) is an anorectal fistula with many external openings and channels, with the internal opening flowing through the deep layer of the external sphincter and impacting the upper two-thirds.
➡️The particular anatomical features of the human body present obstacles in treating this kind of AF, resulting in a high recurrence rate.
➡️The primary purpose of this study was to assess the long-term efficacy and safety of loose combined cutting seton (LCCS) in individuals with HAF.
➡️The evidence suggests that LCCS surgery for HAFs improves postoperative wound healing while reducing healing time, pain and complications, making it a valuable clinical practice for wider use.

🔗READ THE ARTICLE: https://advances.umw.edu.pl/en/ahead-of-print/204335/

13/05/2026

👩🏻‍💻📓✍🏻💡Progressio Infantis

The 5th edition of the International Scientific Conference Progressio Infantis 2026 will take place at the Wroclaw Medical University on May 29–30, 2026. The theme of this year’s event is Knowledge Shaping the Future of the Youngest.

👨🏻‍🏫Progressio Infantis is an interdisciplinary conference dedicated to supporting the development of children and adolescents in its various aspects. The event is addressed to researchers, practitioners, parents, educators, and students in fields related to the development of the youngest.

👨🏻‍🏫The program includes, among others, expert sessions, student scientific sessions, and practical workshop sessions. A competition for student oral presentations and posters is also planned. All works will be presented within panels covering the following topics:

➡️Development – an interdisciplinary perspective
➡️Living with a diagnosis: integrating therapy into the child’s world
➡️Science - it gives children wings.
➡️Interesting clinical cases in the developmental age
➡️Young athletes – breaking barriers, creating solutions.

To enable participation for a wide audience and to foster the exchange of international experience, the conference will be held in a hybrid format.

🔗More information about the event: https://konferencje.umw.edu.pl/progressioinfantis/

Our journal is a patron of this conference.

13/05/2026

🚀Recently published 🚀

Evaluation of nurse-led sedation protocols on clinical outcomes in mechanically ventilated adults within intensive care units: A meta-a**lysis of randomized controlled trials

Highlights

➡️Emergency Department (ED) Procedural Sedation and Analgesia (PSA) for patient comfort: PSA in the ED alleviates anxiety, discomfort, and pain during complex procedures, ensuring safety and satisfaction.
➡️Variable patient responses to ED sedative agents: Despite pre-assessments, trained staff, and adverse-event tracking, individual reactions to procedural sedatives differ widely.
➡️Limited safety data from small-scale PSA trials: Most research on sedation agents comprises single-center randomized controlled trials (RCTs) or observational studies with fewer than 100 participants, complicating definitive safety conclusions.
➡️Agent-specific adverse events guide PSA planning: Propofol often triggers respiratory issues, fentanyl and ketamine can cause gastrointestinal disturbances, while ketamine–propofol combinations reduce hemodynamic instability, highlighting the need to tailor sedation by age, comorbidities, and drug risk.

🔗Read the article: https://advances.umw.edu.pl/en/ahead-of-print/203940/

12/05/2026

🚀Recently published 🚀

Expanded clinical target volume and survival in non-operative ESCC: Prognostic benefits and inflammatory risks

Highlights

➡️Expanding GTV-to-CTV margins beyond 2 cm improves local control in esophageal cancer: Margins of 2–3 cm significantly reduce recurrence compared with 2 cm.
➡️Larger GTV–CTV margins increase systemic inflammation but support better prognosis: Elevated inflammatory indices are observed, yet survival outcomes improve.
➡️GTV–CTV margin size is a stronger prognostic factor than inflammatory biomarkers: Radiotherapy field optimization is key for predicting survival in esophageal squamous cell carcinoma.

🔗Read the article: https://advances.umw.edu.pl/en/ahead-of-print/203882/

11/05/2026

📢New call for submissions📢

Call for Submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on Advances in Hand Surgery and Hand Therapy

The hand is a remarkably complex organ, and even minor injury or disease can severely impair its function, making precise assessment essential for accurate diagnosis, effective treatment, and successful rehabilitation.

🧠Hand surgery combines orthopedics, plastic and reconstructive surgery, microsurgery, and traumatology. Advances in techniques, biomaterials, and regenerative medicine continue to improve outcomes and quality of life. Hand therapy – encompassing physiotherapy, occupational therapy, splinting, pain management, and patient education – plays an equally vital role in restoring fine motor skills after delicate surgical repair.

🧠Effective management of hand conditions depends on close interdisciplinary collaboration among surgeons, therapists, and other professionals. Despite progress, challenges remain in achieving long-term functional recovery, improving patient-reported outcomes, and ensuring equitable access to care. Evidence-based healthcare (EBHC) provides the foundation for modern practice, integrating clinical expertise, research evidence, and patient values.

🧠Articles submitted should address the broad field of hand surgery and hand therapy. Contributions may focus on fundamental principles of hand function, such as anatomy and biomechanics, clinical examination, functional assessment, imaging, electrodiagnostic studies, and patient-reported outcome measures, as well as modern diagnostic approaches, surgical techniques, therapeutic strategies, and interdisciplinary care.

Suggested topics include, but are not limited to, hand surgery and hand therapy in the following conditions:

➡️Traumatic injuries: fractures, dislocations, flexor and extensor tendon injuries, nerve and vascular injuries, amputations and replantations, and complex post-traumatic reconstructions.

➡️Degenerative and inflammatory diseases: osteoarthritis, rheumatoid arthritis, scleroderma, and other connective tissue diseases.

➡️Neurological conditions: stroke, tetraplegia, peripheral and central neurologic diseases, and nerve compression syndromes.

➡️Congenital and developmental disorders: congenital anomalies and deformities in children, including malformations requiring surgical correction and long-term therapy.

➡️Metabolic and systemic disorders: diabetes-related hand conditions and other systemic metabolic diseases affecting the hand.

➡️Burns of the hand: acute surgical treatment, reconstructive procedures, and long-term rehabilitation, including scar management, splinting, and functional recovery.

➡️Tumors of the hand and wrist: benign and malignant tumors.
Infections: acute and chronic infections.

➡️Vascular disorders: Raynaud’s phenomenon, ischemic conditions, and vascular insufficiency of the hand.

➡️Iatrogenic and secondary conditions: complications after surgery, contractures, scarring, stiffness, and chronic pain syndromes.

➡️Other common hand problems: Dupuytren’s contracture, trigger finger, ganglion cysts, and other frequently encountered conditions

🔗MORE INFORMATION
https://advances.umw.edu.pl/en/hand-surgery-therapy

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

09/05/2026

📰New category in our journal – Study Protocol articles 📰

✅ Study Protocol articles provide a comprehensive overview of the design of prospective research, aiming to facilitate the dissemination of ongoing studies and enhance transparency in clinical and biomedical research. These articles outline the hypothesis, rationale, methodology, and ethical considerations of the study, serving as a valuable resource for researchers and clinicians.

✅ We consider study protocols for proposed or ongoing prospective clinical research, provided that participant recruitment has not been completed at the time of submission. Protocols for retrospective studies, feasibility studies, or pilot studies are not eligible. Additionally, study protocols will not be considered if any articles reporting data from the study have already been published or are under review.

📌 Submission Guidelines 📌

• Study Protocol articles undergo peer review.
• The manuscript should not exceed 3,500 words.
• A maximum of 10 figures and/or tables may be included.
• The paper should follow a 5-part structure: Highlights, Introduction, Methodology, Discussion, Conclusion.
• The abstract should not exceed 300 words and follow a 4-part structure: Introduction, Methodology, Discussion, Conclusion.
• Formal ethical approval of an appropriate ethics committee is mandatory.
• For clinical studies, registration in a public clinical trial registry is mandatory prior to manuscript submission.
• Authors are strongly encouraged to follow the SPIRIT guidelines (SPIRIT Statement).

This structured approach ensures that Study Protocol articles contribute meaningfully to the research community while maintaining rigorous academic and ethical standards.

https://advances.umw.edu.pl/en/instructions-for-authors/

08/05/2026

📢Out in Health: Health Equity and Innovations in LGBT+ Care📢

Call for submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on LGBT+ Health Equity and Innovation

This Call for Submissions invites Expressions of Interest for a Special Collection of Advances in Clinical and Experimental Medicine, focusing on LGBT+ health equity and innovation.

🧠LGBT+ individuals around the world face unique and persistent health disparities driven by stigma, discrimination, and systemic exclusion from healthcare systems. These inequities result in significantly worse physical and mental health outcomes and limit access to inclusive, culturally competent care.

🧠This Special Collection will offer researchers and clinicians an opportunity to publish original research, meta-a**lyses, and review articles that address these disparities and propose inclusive, personalized, and innovative solutions to improve health outcomes for LGBT+ populations.

This Call welcomes submissions on (but not limited to):

* Mental Health & Well-being
* Sexual & Reproductive Health
* Transgender & Gender-Diverse Health
* Equity in Healthcare Access
* Social Determinants of Health
* Stigma & Healthcare Avoidance
* Community & Public Health Initiatives
* Intersectionality in Health

🔗MORE INFORMATION
https://advances.umw.edu.pl/en/lgbt

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu
Dr hab. Michał Czapla

07/05/2026

🚀Recently published🚀

Hemodynamic impact of remimazolam versus propofol during painless colonoscopy in older adults: A multicenter, single-blind, randomized controlled trial

Highlights

➡️Remimazolam reduces intraoperative hypotension in elderly patients: In patients aged ≥65 years undergoing endoscopic procedures, remimazolam significantly lowered the incidence of hypotensive events compared with propofol, enhancing hemodynamic safety.
➡️Faster onset and smoother recovery with remimazolam sedation: Remimazolam achieved quicker loss of responsiveness and lower post-awakening sedation scores, supporting efficient procedural workflow and faster patient recovery.
➡️Preserved postoperative cognitive function in older adults: Unlike propofol, remimazolam did not cause significant short-term cognitive decline, making it a safer sedative choice for elderly patients at risk of postoperative cognitive dysfunction.
➡️Comparable safety profile with improved tolerability: Remimazolam demonstrated a similar rate of adverse events to propofol while offering superior cardiovascular stability, supporting its preferential use in geriatric anesthesia for endoscopy.

🔗Read the article: https://advances.umw.edu.pl/en/ahead-of-print/205301/

06/05/2026

🤝Meet the author of our latest editorial!🤝

Prof. Sajee Sattayut

✔️ READ THE EDITORIAL

Academic mediator-driven research translation: The concept for making possible implementation

https://advances.umw.edu.pl/en/ahead-of-print/220569/

✔️SHORT BIO

https://ojs.umw.edu.pl/files/acem/CV-Sajee-Sattayut.pdf

✔️MINI-INTERVIEW

1. Which unique features of Thai culture, scientific culture, and health system fostered the achievements described in your editorial?

Thailand's healthcare system emphasizes broad public coverage and community-level services, such as primary care. This fosters close relationships among healthcare professionals, enabling effective collaboration across universities, hospitals, and local services, and aligning research with patient needs. This model is not limited to Thailand; even in less cohesive environments, similar progress is possible. Academic institutions can serve as connectors between evidence, training, local services, and implementation, promoting advancements through structured networks and shared accountability.

2. What caused the interest of Thai specialists in laser dentistry? It seems that this particular field of dentistry and orofacial surgery is particularly well developed in your country compared to other countries in the Far East.

In Thailand, the interest in laser dentistry has grown from a unique perspective. Instead of viewing lasers merely as clinical tools, we emphasize understanding lasers as a discipline. This enables dentists to decide how and when to use lasers for effective and safe patient care. Due to the high costs associated with laser devices, practitioners in Thailand must carefully consider their purchases. As a result, there is a strong focus on using lasers in a rational and context-appropriate manner to achieve meaningful clinical outcomes. This approach has led to the establishment of the Hub of Knowledge in Orofacial Laserology, which creates a shared learning space for laser dentistry at both national and international levels. This initiative has contributed to the systematic and sustainable development of the field in Thailand.

3. Could you elaborate on the implementation of laser dentistry within local health services in rural areas of Thailand?

The development of laser dentistry in rural Thailand took a unique approach by focusing on local health service needs, such as wound healing, pain control, and bleeding management, rather than advanced surgical applications. This resulted in a primary-care laser model specifically designed for community settings. Local hospitals transformed into learning centers, sharing experiences, training nearby units, and contributing data to the university network. This collaborative effort has become a distinctive aspect of Thailand's experience in laser dentistry. We are pleased to highlight this pioneering contribution from Thailand to the broader field of laser dentistry implementation.

05/05/2026

📢New call for submissions 📢

📢 Innovations in Therapeutic Interventions: Advancing Clinical and Experimental Medicine 📢

We welcome reviews as well as original research articles and research letters in various clinical and experimental medicine areas. We encourage submissions on the following topics:

🧠Precision Medicine and Personalized Therapies: Explore novel approaches in tailoring medical treatments based on an individual's genetic makeup, environmental factors, and disease characteristics. Highlight the potential of precision medicine in improving patient outcomes and overcoming treatment challenges. This topic includes but is not limited to:

➡️Immunotherapy and Immunomodulation: Investigate the role of immunotherapy and immunomodulation in treating various diseases, including cancer, autoimmune disorders, and infectious diseases. Focus on cutting-edge techniques, therapeutic targets and potential synergies with other treatment modalities.

➡️Gene and Cell Therapies: Present innovative research on gene and cell-based therapies, such as stem cell transplantation, gene editing and regenerative medicine. Explore their applications across different diseases and discuss their clinical implications and prospects.

🧠Artificial Intelligence and Big Data Analytics in Medicine: Examine the integration of artificial intelligence (AI) and big data a**lytics in medical research, diagnostics, treatment optimization, and patient care. Highlight the potential of AI algorithms, machine learning and data-driven approaches in revolutionizing healthcare practices.

🧠Digital Health Technologies and Wearables: Discuss the advancements in digital health technologies (including telemedicine), wearable devices and remote monitoring systems. Explore their impact on healthcare delivery, patient engagement, disease management, and prevention strategies.

🧠Translational Research and Bench-to-Bedside Innovations: Showcase translational research efforts that bridge the gap between laboratory discoveries and clinical applications. Present successful examples of bench-to-bedside innovations that have improved patient care and outcomes.

🔗MORE INFORMATION
https://advances.umw.edu.pl/en/innovations

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

Advances in Clinical and Experimental Medicine

15/05/2026

14/05/2026

13/05/2026

13/05/2026

12/05/2026

11/05/2026

09/05/2026

08/05/2026

07/05/2026

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