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Biomechanics Wellness PR, MMFitness, San Juan (2025)

28/10/2025

28/10/2025

Creatine goes well beyond the gym

Creatine is best known as a performance enhancer in sports. But growing research suggests its benefits may extend far beyond athletic performance with potential roles in mental health, stroke protection, and heart failure.

🧠 Mental Health
Creatine boosts brain energy metabolism and may influence neurotransmitters.

Early studies suggest it may have antidepressant effects.

Potential as an adjunctive therapy in major depressive disorder, especially in treatment-resistant cases.

🟢 Example: By stabilizing brain ATP levels, creatine may help support mood regulation.

🧠🩸 Stroke & Ischemia
In preclinical models, creatine shows neuroprotective effects:

Reduced infarct size (less tissue death).

Preserved mitochondrial function under oxygen deprivation.

Stabilized ATP, lowering oxidative stress.

🟢 Example: These findings suggest creatine could help protect the brain during ischemic events.

🫀 Heart Failure
Heart failure involves a chronic mismatch between ATP supply and demand in heart cells.

Creatine supports the Cr/PCr/ATP shuttle, restoring cellular energetics.

Clinical results are mixed, but the mechanistic rationale remains strong.

🟢 Example: By replenishing energy stores, creatine may complement conventional heart therapies.

Creatine is evolving from a sports supplement into a potential therapeutic tool. While more human trials are needed, evidence points toward its role in stabilizing energy metabolism, reducing oxidative damage, and protecting vulnerable tissues from brain to heart.