10/08/2025
Featured Case Study:
Mixed Phenotype Acute Leukemia (T/Myeloid MPAL) with BCR::ABL1 Fusion in a Hispanic Patient
🔍Case Highlights:
A 61-year-old woman presents with generalized lymphadenopathy.
Lymph node biopsy reveals blasts expressing both myeloid (MPO, lysozyme) and T-cell markers (CD3, CD4, CD5, CD7).
Bone marrow confirms MPAL; molecular testing detects the BCR:: ABL1 fusion, a key driver mutation.
💡Clinical Significance:
MPAL is rare, with the T/Myeloid subtype especially challenging due to its mixed lineage and extramedullary presentation. The presence of BCR::ABL1 further complicates treatment strategies.
This case showcases the necessity of integrated diagnostics— combining morphology, immunophenotyping, and molecular assays— to guide targeted therapy and improve patient outcomes.
Thanks to Dr. Camille Santiago for this incredible paper!
• Full Case (Open Access): https://pubmed.ncbi.nlm.nih.gov/40605863/
