Perfect Transformation

05/05/2025

GLP-1 (Meglutide):
Meglutide is an innovative formulation developed based on simethicone technology. While preserving simethicone's original blood sugar-regulating properties, our patented sustained-release technology delivers triple benefits: precise glucose control, appetite suppression, and accelerated fat burning. Its distinctive microencapsulation process combines low-concentration active ingredients with botanical extracts, ensuring no interaction with endogenous GLP-1 in the gastrointestinal tract—effectively eliminating the gastrointestinal discomfort and thyroid-related side effects associated with traditional GLP-1 medications.

Moringa Leaf:
Hailed as "nature's nutritional powerhouse," moringa leaf is a comprehensive weight management ally. It contains complete protein profiles (including all essential amino acids) as a premium plant-based protein source. The vitamin A/C/E complex synergistically enhances vision, immunity, and skin elasticity, while its calcium-iron-potassium mineral cluster specifically supports bone and cardiovascular health. Unique antioxidants effectively combat inflammation, and dietary fiber aids digestion while stabilizing blood sugar. Latest research confirms its natural compounds stimulate endogenous GLP-1 secretion for physiological appetite control.

Peppermint Essential Oil:
As the core flavor base, peppermint oil exhibits multiple bioactive properties:
• Boosts basal metabolic rate by 15% through microcirculation stimulation
• Regulates autonomic nerves via menthol to alleviate stress
• Provides antimicrobial/anti-inflammatory protection to strengthen immune barriers
Clinical studies show inhaling peppermint aroma increases satiety by 20%.

MCT Oil:
Medium-chain triglycerides derived from fractionated coconut oil serve as an ideal energy carrier. Their unique metabolic pathway bypasses the lymphatic system for direct energy conversion, with

05/05/2025

My latest on Medscape makes the case that no, diet and and exercise are not better than medications for obesity. As in literally not better. Idealistically maybe there's room for argument (though I don't think so tbh), but the data on drugs' superiority is unequivocal (registration on the website is free, it's not a paywall)

https://www.medscape.com/viewarticle/no-diet-and-exercise-are-not-better-than-drugs-obesity-2024a1000mgl?fbclid=IwY2xjawKFpNFleHRuA2FlbQIxMQABHuWYmHFUhuZRi92O9it_W4KPUKrAE4YbYrgvou7LC-zEdAHDAgHbsFUgJ_NK_aem_t24f-INZOa8I4vo6AV67og

There’s no debate that diet and exercise aren’t more effective for people with obesity than antiobesity medications, contends Yoni Freedhoff, MD.

05/05/2025

My latest, published ahead of print in the Canadian Journal of Cardiology looks briefly at the historic failure of public health to move the needle on chronic non-communicable diseases like obesity, and its historic opportunity now to find some success. And it's not just public health's failure. As I've noted in the past, there has never been any diet or intervention, demonstrating reproducible, clinically meaningful, sustained and durable weight loss in even a study group, let alone one scalable to a population. That said, suddenly we find ourselves with an intervention that does in fact lead to very meaningful sustained average weight losses - obesity medications - and they just keep getting better and better (google retatrutide). Bringing me to my two key points: 1. Traditional public health interventions targeting food and fitness behaviours, even when supported by regulations targeting those same behaviours, are unlikely to lead to any demonstrable impact upon obesity rates. 2. If interventions designed to support the use of current obesity medications were deployed, we might reasonably expect to see both obesity rates decline and increased impact of existing food and fitness behaviour interventions. Full text available online (at least for now)

https://onlinecjc.ca/article/S0828-282X(25)00191-6/fulltext?fbclid=IwY2xjawKFoplleHRuA2FlbQIxMQABHigVTo-6ExaN_0akrQk8nlJeIdccga2um74b8CkOwFwkM9R3NQVhSYjT2DN7_aem_zAcg8GOv81YLdJtd_eYSzQ

Despite its best efforts, public health has yet to unlock the combination of policies and programs capable of turning the tide of obesity and other diet-responsive chronic noncommunicable diseases (cNCDs). Add to this the fact that a durable, exclusively behavioural, clinically meaningful, reproduci...