20/05/2025
https://www.facebook.com/share/1AUXsU8GoF/
How Chronic Inflammation Promotes Tumor Progression👇
📎Chronic inflammation plays a critical role in cancer development. It promotes tumor initiation, progression, and metastasis.
📎Inflammatory signals activate key pathways like IKK-NF-κB, MAPK-AP-1, and JAK-STAT3, which drive tumor growth by promoting cell survival and proliferation.
📎The tumor microenvironment, including immune cells (like macrophages, neutrophils, and T lymphocytes), releases cytokines (e.g., IL-1, IL-6, TNF) and growth factors, creating conditions that support cancer progression.
📎Inflammation also enhances angiogenesis through VEGF and tissue remodeling via MMP, facilitating metastasis to distant organs.
📎Understanding the link between inflammation and cancer can help develop targeted therapies.
💡 For more info: Hibino, S.; Kawazoe, T.; Kasahara, H.; Itoh, S.; Ishimoto, T.; Sakata-Yanagimoto, M.; Taniguchi, K. Inflammation-Induced Tumorigenesis and Metastasis. Int. J. Mol. Sci. 2021, 22, 5421.