The Endocrine Club

The Endocrine Club General endocrinology and diabetes practical points
Chairman/admin :
Abdulqawi Almansari MBBS FACP FACE

Chairman Abdulqawi Almansari MD FACP FACE
Consultant endocrinologist
Myclinic alsafa Jeddah
American board of Endocrinology Diabetes and Metabolism2000
American Board internal Medicine 1998

05/08/2025

Initiating SGLT2 inhibitors early in the management of type 2 diabetes has been shown to slow the progression of chronic kidney disease, with additional potential benefits for heart failure and coronary artery disease.

46 y M with no complaint no goiter clinically euthyroid was referred for below TFT... What is the next step
05/08/2025

46 y M with no complaint no goiter clinically euthyroid was referred for below TFT... What is the next step

05/08/2025

It was calculated that 80% of normal BMI people are likely to live till 70 years
But only 50% if BMI over 40

04/08/2025

For every 5 kg/m² increase in BMI above ~22.5 kg/m², overall mortality risk rose by approximately 29%

Prospective Studies Collaboration Lancet 2009

04/08/2025

Screening for acromegaly with IGF-1 measurement is recommended for all patients with pituitary tumors
Endocrine Society and Pituitary Society

04/08/2025

The European Medicines Agency EMA has approved the use of all commercially available human GLP-1 analogs up to a minimal eGFR of 15 mL/min/1.73 m2

03/08/2025

Over the past decade, the landscape of diabetes management has transformed significantly, largely due to the introduction of two innovative classes of anti-diabetic medications: SGLT2 inhibitors and GLP-1 receptor agonists. These therapies have gone beyond glucose control, demonstrating substantial benefits in reducing complications such as chronic kidney disease, heart failure, myocardial infarction, and stroke.

03/08/2025

Erythrocytosis is a common adverse effect of testosterone therapy in older men. its dose-dependent
Testosterone increases erythropoiesis by direct stimulation of the bone marrow, stimulation of erythropoietin secretion, and suppression of hepcidin that is secreted by the liver
ESAP 2025

03/08/2025

Plasma C-peptide levels are highly associated and predictive of the accurate classification and diagnosis of diabetes types. A plasma C-peptide cutoff of ≤0.20 mmol/L is indicative of T1D and of ≥0.30 mmol/L in the fasting or random state is indicative of T2D
Rev article endocrine practice Jan 2023

03/08/2025

Postprandial glucose is associated with CV events . People with T2D who died during the 11-year follow-up of the Diabetes Intervention Study had significantly higher PPG levels at screening but not significantly higher FBG levels.

02/08/2025

Solid thyroid nodules suspicious features are
1- irregular margin
2- taller than wide shape
3- intrasolid punctuate echogenic foci
4- macro calcifications
EDEC 2025 presentation

02/08/2025

Surgery is recommended for asymptomatic patients with primary hyperparathyroidism if any of the following are present:
1. Serum calcium >1.0 mg/dL (0.25 mmol/L) above the upper limit of normal.
2. T-score ≤ –2.5 at lumbar spine, total hip, femoral neck, or distal 1/3 radius (DXA scan). Vertebral fracture by imaging (e.g., X-ray, VFA, CT, or MRI).
3. eGFR < 60 mL/min/1.73 m²
24-hour urinary calcium > 400 mg/day, and increased stone risk.
Presence of nephrolithiasis or nephrocalcinosis (on imaging, even if silent).
4. Age < 50 years.
5. Patient preference

Endocrine Society 2014

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