21/09/2023
Ankylosing Spondylitis
Clinical Features:
Ankylosing Spondylitis is a chronic inflammatory disease that primarily affects the spine, causing fusion of the vertebrae and resulting in a condition known as "bamboo spine."
The clinical features of Ankylosing Spondylitis include:
1. Chronic lower back pain: Patients often experience persistent lower back pain that is worse in the mornings and improves with exercise.
2. Stiffness and limited range of motion: The spine becomes progressively stiff and inflexible, leading to difficulty in bending and twisting.
3. Enthesitis: Inflammation at the sites where tendons and ligaments attach to the bones, commonly affecting the heels and pelvis.
4. Sacroiliitis: Inflammation of the sacroiliac joints, causing pain and stiffness in the buttocks and lower back.
5. Fatigue: Many patients with Ankylosing Spondylitis experience chronic fatigue, which can significantly impact their daily activities
Cause:
The exact cause of Ankylosing Spondylitis is unknown, but it is believed to involve a combination of genetic and environmental factors. The HLA-B27 gene is strongly associated with the development of Ankylosing Spondylitis, although not all individuals with this gene develop the disease.
FAQS:
1. Can Ankylosing Spondylitis be cured? Ankylosing Spondylitis is a chronic condition with no known cure. However, timely treatment and management can help control symptoms and prevent disease progression.
2. Is Ankylosing Spondylitis hereditary? There is a strong genetic component to Ankylosing Spondylitis, with the HLA-B27 gene being a significant risk factor. However, not all individuals with the gene develop the disease, suggesting that other factors also contribute to its development.
3. Can exercise worsen Ankylosing Spondylitis symptoms? Regular exercise and physical therapy are essential components of Ankylosing Spondylitis management. While some activities may need to be modified, overall, exercise helps maintain flexibility, reduce pain, and improve overall function.
4. Can Ankylosing Spondylitis affect other joints besides the spine? Yes, ankylosing spondylitis can affect other joints, such as the hips, shoulders, and knees. Additionally, it can also involve other organs, including the eyes (uveitis) and intestines (inflammatory bowel disease).
5. Can pregnancy worsen Ankylosing Spondylitis symptoms? Pregnancy can have variable effects on Ankylosing Spondylitis symptoms. Some women experience improvement during pregnancy, while others may have worsening symptoms. Close monitoring and appropriate management are necessary during pregnancy.
