Carmine Belin Lab

Carmine Belin Lab Research laboratory at the Karolinska Institutet, Stockholm, focusing on neurological disorders like primary headache disorders.

The purpose of our research is to increase the understanding of the pathophysiology of neurological disorders with a focus on primary headache disorders such as migraine and cluster headache (CH) by identifying, characterizing and modelling genetic markers within the human genome. Certain rare forms of these conditions are monogenic and there is increasing evidence that genetic factors are important also for sporadic forms. We suggest that there are multiple genetic factors that combine in different ways to increase or decrease risk for disease. They need to be identified in order to begin unwinding the causative pathways leading to the different forms of the disorders. Knowledge about gene function and findings from linkage and genome-wide association studies are applied to clinical material (DNA and cell lines) collected from patients with migraine and CH as well as neurologically healthy controls to decipher genetic factors. Key genetic findings are evaluated by:

1. Quantification of possible candidate gene and protein expression differences caused by genetic variation in biological samples and in silico

2. Characterization of candidate gene and protein expression in human and rodent tissue

3. Development and characterization of transgenic animal models. The identification of new genetic risk and protective markers for these disorders should allow insight into the pathophysiological mechanisms, and thereby lead to improved diagnosis and aid in the development of novel classes of drugs able to prevent and/or counteract disease.

04/11/2025

Dags att ansöka om forskningsstipendium för finansiera projekt inom ämnesområdet huvudvärk.
H. Lundbeck AB har i samarbete med Svenska Huvudvärkssällskapet instiftat ett forskningsstipendium för att stödja forskning i Sverige inom huvudvärkssjukdomar. Deadline 15 december 2025!
Mer info: https://brainhub.se/

Time for KI Fun Run 2025☀️! So much fun and well organized by 👏🏻👏🏻👏🏻!
25/09/2025

Time for KI Fun Run 2025☀️! So much fun and well organized by 👏🏻👏🏻👏🏻!

Thank you for a fantastic conference in São Paulo🇧🇷!
14/09/2025

Thank you for a fantastic conference in São Paulo🇧🇷!

Check out our new article on sleep disturbances and cluster headache:
04/09/2025

Check out our new article on sleep disturbances and cluster headache:

Researchers at Karolinska Institutet have found that individuals with cluster headache have symptoms of insomnia and poor sleep quality in an active headache period, and sleep is not restored during headache-free periods. The results were recently published in Headache: the Journal of Head and Face....

07/08/2025

Andrea Carmine Belin forskar på klusterhuvudvärk på Centrum för Klusterhuvudvärk vid Karolinska institutet.

Dr Felicia Jennysdotter Olofsgård on summer lab exchange at beautiful Lund University in collaboration with Dr Jacob Edv...
18/07/2025

Dr Felicia Jennysdotter Olofsgård on summer lab exchange at beautiful Lund University in collaboration with Dr Jacob Edvinsson☀️!

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Solnavägen 9
Stockholm
17177

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+46852487051

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