18/10/2019
A summary of a new paper entitled at The Impact of Food Additives on Gut Homeostasis: a discussionary review of literature.
“…The Western diet is characterized by high consumption of proteins, saturated fats and sweets, as well as by a broad use of food additives (e.g., emulsifiers, bulking agents) used to preserve and enhance food quality…”
“…Accumulating evidence suggests that food additives can perturb gut homeostasis, thereby contributing to promote tissue-damaging inflammatory responses…”
“…In this review, we report and discuss the current knowledge about the impact of food additives on gut homeostasis and their potential contribution to the development of inflammatory disorders…”
“…(There is a need to evaluate) potential detrimental effects of these substances on human health, especially for those subjects with intestinal or systemic disorders (e.g., IBD patients, metabolic syndrome patients) or increased susceptibility to pathogenic conditions (e.g., relatives of colon cancer patients, relatives of IBD patients)…”
“…[Recently] many pre-clinical studies have recently linked the increased and prolonged consumption of food additives with the development and progression of various forms of colitis, colorectal cancer, and metabolic syndrome, which is characterized by increased adiposity, dysglycemia, and low-grade intestinal inflammation…”
For example…
“…[Recent] findings have suggested that dietary emulsifiers may have an impact on the gut-brain axis and induce psychological/behavioral disorders in the exposed subjects through a microbiota-dependent mechanism…” (Think products like OATLY Ikaffe and margarine/spreads that melt easily).
“…[In addition] accumulating evidence suggests that maltodextrin can impair gut homeostasis via multiple mechanisms and promote intestinal pathologies… for instance, maltodextrin has been involved in the development of necrotizing enterocolitis (NEC), a severe intestinal disorder of the newborns…” (Most välling/formula contains maltodextrin, which is one reason we can’t give formula to preemies).
“…[Moreover] a recent study… investigated the impact of the exposure to titanium dioxide… a commonly used inorganic nanoparticle…food colorant… in pregnant rats… [with] the authors reporting… [changes] in gut microbiota composition at gestation day 10 and 17…in addition [to increased], fasting blood glucose levels, together with the expression of diabetes mellitus-related genes… in the exposed rats… [suggesting] that titanium dioxide particles may exert detrimental effect in pregnant women…”
“…Silver nanoparticles… [have also been observed] to damage intestinal microvilli and glands in the small intestine, cross the intestinal epithelial barrier and decrease body weight of treated mice…however, it is noteworthy that the effects of silver nanoparticles on gut homeostasis would seem to be strictly dependent on particle size, dosage and administration route…”
“…Finally, it is important to point out that intake of anti-microbial agents can also occur through the usage of cosmetics and personal care products…”
“….An example is given by triclosan, a biocidal additive found in several products, such as toothpastes, cosmetics and toys… [and] exposure to low-doses of triclosan (10 and 80 parts per million in diet) promotes low-grade intestinal inflammation, colitis and colitis-associated colon carcinogenesis in mice…”
“…[With one analysis demonstrating] the mechanisms underlying these effects are dependent on the ability of triclosan to promote gut dysbiosis and trigger the signalling cascade downstream the Toll-like receptor 4, a LPS recognizing receptor whose activation promotes intestinal inflammatory responses…”
In conclusion
“…An accumulating number of studies reported detrimental effects of some commonly used food additives on gut homeostasis, suggesting a link between their consumption and the development/worsening of human intestinal and metabolic diseases…”
“…Since most of the studies published so far have been performed in animals, it would be relevant to ascertain whether similar effects occur also in human beings before drawing any conclusion on the deleterious effect of additives on gut homeostasis.”
https://www.mdpi.com/2072-6643/11/10/2334
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