Acta Dermato-Venereologica

Acta Dermato-Venereologica Acta Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs to enhance understanding.

Acta Dermato-Venereologica (ActaDV) is a truly international Open Access journal for clinical and experimental research in the field of dermatology and venereology. Acta Dermato-Venereologica publishes high-quality manuscripts in English dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of Revie

w articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations.

High-content Image-based Drug Testing of Patients’ Primary Fibroblasts Reveals Potential New Treatment Options for Local...
03/08/2025

High-content Image-based Drug Testing of Patients’ Primary Fibroblasts Reveals Potential New Treatment Options for Localized Scleroderma

Authors: Katariina Mähönen, Isabel Mogollon, Antti Hassinen, Minttu Polso, Katja Välimäki, Swapnil Potdar, Al-Amin Chowdhury, Annamari Ranki, Jani Saarela, Vilja Pietiäinen, Jaana Panelius

Localized scleroderma is an autoimmune connective tissue disease, where chronic inflammation and abnormal activation of myofibroblasts leads to permanent skin fibrosis. Currently there are no specific therapies targeting fibrosis. In this study, we aimed to find potential new antifibrotic treatments for localized scleroderma, using image-based drug screening assay for fibroblasts isolated from the skin of localized scleroderma patients. We found several drug groups with antifibrotic effects, among them inhibitors of tyrosine kinase, transforming growth factor β receptor, and phosphoinositide-3 kinase, as well as androgen receptor antagonists. Our study suggests new treatment options for localized scleroderma.

https://doi.org/10.2340/actadv.v105.43088

Hand Eczema and Facial Skin Problems – Association with Occupational Exposures among Community Care Personnel in Sweden:...
03/08/2025

Hand Eczema and Facial Skin Problems – Association with Occupational Exposures among Community Care Personnel in Sweden: A Cross-sectional Study

Authors: Thanisorn Sukakul, Nils Hamnerius, Tina Lejding, Kajsa Davidson Källberg, Anna Josefson, Ebba Detlofssen, Cecilia Svedman

Work-related hand eczema and facial skin problems are of concern not only in healthcare workers but also in community care workers. Occupational exposure to soap, water, and face masks is significant, dose-dependent factors contributing to these issues. Efforts should be directed at reducing the harmful effects of hygiene procedures and protective equipment both in community care and healthcare work to ensure the well-being of those dedicated to caring for others.

https://doi.org/10.2340/actadv.v105.43771

03/08/2025

A Linear Elevation of the Skin Along the Periphery of the External Nostrils: A Quiz

Authors: Minako Tanimura, Yasuaki Ikuno, Akihiko Yamaguchi, Toshifumi Takahashi, Noriki Fujimoto

Clinical photograph. A linear elevation of the skin along the periphery of the external nostrils.

What is your diagnosis?
1: Adult xanthogranuloma
2: Verruca vulgaris
3: Lymphomatoid papulosis
4: Adult T-cell leukaemia-lymphoma

See https://doi.org/10.2340/actadv.v105.44155 for answer

The Predictive Value of Serum Total IgE for Antihistamine Treatment Outcomes in Chinese Patients with Chronic Spontaneou...
03/08/2025

The Predictive Value of Serum Total IgE for Antihistamine Treatment Outcomes in Chinese Patients with Chronic Spontaneous Urticaria

Authors: Yingyi Li, Rui Peng, Jingwen Xue, Yi Zhao

Chronic spontaneous urticaria presents a significant challenge for dermatologists, as many patients do not respond to standard treatment with second-generation H1-antihistamines (sgAHs). While dose escalation may benefit some patients, others remain refractory. Identifying predictors of treat-ment response is essential to avoid prolonged suffering and accelerate access to effective therapies.
In a cohort of 99 Chinese chronic spontaneous urticaria patients, higher serum total IgE was linked to poorer response – though individual values overlapped substantially. This suggests that baseline total IgE can serve as a risk indicator for nonresponse to standard‐dosed antihistamine therapy. Cli-nicians might use baseline IgE levels alongside other clinical markers to decide when to escalate treatment or introduce alternative options, helping those with refractory chronic spontaneous urti-caria receive appropriate care sooner.

https://doi.org/10.2340/actadv.v105.43568

03/08/2025

Recurrent Red Papules in a Satellite Pattern Following Laser Treatment: A Quiz

Authors: Xilan Chen, Jia Chen, Bingjie Zheng, Xiao Lin

Clinical photograph. Primary solitary red papillary nodule with a diameter of 7 mm.

What is your diagnosis?
1: Recurrent pyogenic granuloma
2: Cherry angioma
3: Angiokeratoma
4: Folliculitis

See https://doi.org/10.2340/actadv.v105.43255 for answer

Successful Treatment of Papuloerythroderma of Ofuji Associated with Helicobacter pylori InfectionAuthors: Erika Tanizaki...
03/08/2025

Successful Treatment of Papuloerythroderma of Ofuji Associated with Helicobacter pylori Infection

Authors: Erika Tanizaki, Kazuyasu Fujii, Shunya Usui, Nana Kagawa, Atsushi Otsuka

https://doi.org/10.2340/actadv.v105.43247

Early Recurrence of Nodular Basal Cell Carcinoma Despite Negative Margins: A Case ReportAuthors: Yuto Yamamura, Kazuyasu...
25/07/2025

Early Recurrence of Nodular Basal Cell Carcinoma Despite Negative Margins: A Case Report

Authors: Yuto Yamamura, Kazuyasu Fujii, Chisa Nakashima, Shunya Usui, Atsushi Otsuka

https://doi.org/10.2340/actadv.v105.44195

The Clinical Spectrum of Rare Inherited Ichthyosis in China: A Review of Thirty-five CasesAuthors: Ruiyu Xiang, Xin Huan...
25/07/2025

The Clinical Spectrum of Rare Inherited Ichthyosis in China: A Review of Thirty-five Cases

Authors: Ruiyu Xiang, Xin Huang, Yihe Liu, Shuya Sun, Di Hua, Ran Mo, Yong Yang, Zhiming Chen

This is a case series of rare inherited ichthyoses, involving 35 cases with syndromic or non-syndromic ichthyoses. There were cases of autosomal recessive congenital ichthyosis (18/31), epi-dermolytic ichthyosis (9/31), and superficial epidermolytic ichthyosis (4/31). Additionally, four patients were diagnosed with syndromic ichthyosis, comprising one case of Chanarin-Dorfman syndrome and three cases of Netherton syndrome. The genetic analysis revealed a total of 47 vari-ants across 13 genes, of which 19 new variants are first reported here. Some patients have typical symptoms, but others present a clinical phenotype that does not match the genetic diagnosis. For example, congenital ichthyosiform erythroderma, lamellar ichthyosis, and rare Harlequin ichthyosis are the typical clinical types of autosomal recessive congenital ichthyosis, but we found patients with autosomal recessive congenital ichthyosis can also present with erythrokeratodermia variabilis, which may be caused by ABCA12 and PNPLA1 variants. Thus, this work further expands the clini-cal and genetic spectrum of ichthyosis and provides more information for dermatologists to help diagnose rare ichthyosis.

https://doi.org/10.2340/actadv.v105.41100

19/07/2025

Skin Erosion on the Nasal Root with Marked Right Eyelid Swelling: A Quiz

Authors: Yoshihito Mima, Masako Yamamoto, Ken Iozumi

Clinical photograph. Physical examination revealed an ulcerated lesion on the nasal root (black arrow) and marked swelling of the right upper eyelid without pain (white arrow).

What is your diagnosis?
1: Diffuse large B-cell lymphoma
2: Metastatic tumour
3: Actinic keratosis
4: Squamous cell carcinoma

See https://doi.org/10.2340/actadv.v105.43874 for answer

Awareness, Patient Behaviour, and Treatment Expectations in a French Cohort with Actinic Keratosis (REAKT Survey)Authors...
19/07/2025

Awareness, Patient Behaviour, and Treatment Expectations in a French Cohort with Actinic Keratosis (REAKT Survey)

Authors: Jean-Michel Amici, Pierre Lévy, Gregory Caillet, Chantal Touboul, Jean-Michel Joubert, Brigitte Dréno

• Timely and effective management of actinic keratosis (AK) is fundamental to reduce the risk of progression of AK to squamous cell cancer.
• Public awareness of AK and its associated health risks is limited.
• Many people with physician-diagnosed AK lesions have erroneous beliefs;; for instance, 21% of patients in our survey disagreed that AK lesions could be precursors of skin cancer.
• This knowledge gap may not be widely appreciated by physicians and ensuring adequate information and education of patients with AK should be a priority for them.
• Patients with AK are strongly in favour of their physicians proposing regular skin examinations.
• Sun protection behaviour was sub-optimal in people with physician-diagnosed AK lesions.
• Satisfaction with AK treatments is limited: treated patients frequently reported that lesions persisted following treatment.
• They also consider that certain treatments were complicated to use and made their skin painful or unsightly.
• There is thus an unmet need for more effective and acceptable treatments.
• Better information and education for AK patients are needed, as well as more acceptable topical treatments.

https://doi.org/10.2340/actadv.v105.43351

Alopecia Areata: Impact on Patients’ Quality of Life and Disease Perception: A Survey-Based StudyAuthors: Christian Vest...
19/07/2025

Alopecia Areata: Impact on Patients’ Quality of Life and Disease Perception: A Survey-Based Study

Authors: Christian Vestergaard, Daniel de la Rosa Carrillo, Randeep Mandla, Anne Grete Frøstrup, Susanne T. Gren, Petri Vänni, Anna-Kaisa Asikainen, Kristian Kofoed, Cato Mørk

This study highlights the personal struggles faced by individuals with alopecia areata, particularly how it impacts their daily lives and well-being. It sheds light on the disconnect between traditional assessment tools and the lived experiences of those affected. The findings emphasize the need for more patient-centred tools that take into account the emotional and psychosocial challenges of alopecia areata in addition to its physical symptoms. This research will contribute to existing studies by offering a deeper understanding of patient perspectives, ultimately improving care and support for individuals coping with this chronic condition.

https://doi.org/10.2340/actadv.v105.43318

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Acta Dermato-Venereologica publishes high-quality manuscripts in English dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of Review articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations. Acta Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs to enhance understanding. www.medicaljournals.se/acta/

Acta Dermato-Venereologica covers basic and clinical studies encompassing:


  • Atopic dermatitis and contact allergy

  • Facial dermatoses and adnexal disorders