22/11/2025
Ginseng acts similarly to engineered peptides when it comes to collagen function, activating the Smad signaling pathway.
This directly triggers the COL1A2 promoter—the gene responsible for synthesizing fresh Type I Procollagen.
Panax Ginseng is an ethnobotanical with traditional uses, but modern science has also unveiled its dual-action modulation on the fibroblast. It upregulates the COL1A2 gene via the Smad signaling pathway, mimicking collagen and cell repair signals.
It also significantly inhibits MMP-1, the primary enzyme responsible for breaking down Type I collagen fibers.
In our CellTalk CC Cream , I paired the botanical extract with synthetic actives such as
Palmitoyl Pentapeptide-4 and adenosine.
By combining MMP Inhibition (Ginseng) with Direct Peptide Signaling (Palmitoyl Pentapeptide-4 + Adenosine), the formula achieves a synergistic effect that single-active products often miss.
Save this for your formulation notes. 🔖