Agency for Care Effectiveness - ACE

Agency for Care Effectiveness - ACE ACE is the national health technology assessment (HTA) and clinical guidance agency in Singapore. What We Do


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Welcome to the official page of the Agency for Care Effectiveness (ACE). Established by the Ministry of Health, the Agency for Care Effectiveness (ACE) is the national Health Technology Assessment (HTA) and Clinical Guidance Agency in Singapore. We support providers, patients, and payers make better-informed decisions about patient care. We achieve this by conducting health technology ass

essments (HTAs), publishing healthcare guidances and providing education. HTA

Established by the Ministry of Health in 2015, we are the national HTA agency in Singapore. We conduct technical evaluations that inform funding decisions for health technologies, and drive their appropriate use by:

• Publishing technology guidances on the clinical effectiveness, safety, and cost-effectiveness of health technologies;
• Conducting value-based pricing negotiations with manufacturers to ensure that prices of patented health technologies are commensurate with the outcomes they deliver for patients and the Singapore health system;
• Tracking utilisation and outcomes related to funded health technologies to study the impact of funding decisions;
• Developing and implementing adoption strategies within public healthcare institutions to drive uptake of technology guidances. Clinical Guidance

We develop and publish clinical guidances that provide concise, evidence-based recommendations to inform specific areas of clinical practice. Healthcare Professional Education

We assist healthcare professionals to apply the best available evidence in their practice through collaborative continuing professional education. Healthcare Consumer Education

We provide information and tools for patients and caregivers to help them find out more about different medical conditions and treatment options, and to take part in shared decision-making with their clinicians about their healthcare needs. Find out more about our work at https://www.ace-hta.gov.sg/campaign/

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Social Media Terms of Use

We encourage all visitors on our page to start conversations and share with us your thoughts, suggestions, and comments, if any. While we welcome constructive discussions, and want everyone’s experience to be positive, please note that any offensive posts or comments will be removed, and users that repeatedly breach the terms of use may also be blocked from this page. As social media is not a platform for clinical advice – please get in touch with your pharmacist or doctor regarding medical queries. Out of respect for users of our page, ACE reserves the right to remove any comments or posts of the following nature:
- Abusive, vulgar, obscene, violent or defamatory language
- Hateful or discriminatory remarks towards any specific groups or individuals
- Advertising, promotion or endorsement of any products, services or brands
- Fraudulent, inaccurate, non-evidence based information, including spam
- Violation of any copyright, contains proprietary or personal information (email addresses, phone numbers, account numbers etc.)
- Any other comments or posts that breach Facebook’s Term of Service of Community Standards.

Since MOH’s Circular on the Diagnosis and Management of Dengue Fever (DF) / Dengue Haemorrhagic Fever (DHF) in 2015, new...
08/04/2026

Since MOH’s Circular on the Diagnosis and Management of Dengue Fever (DF) / Dengue Haemorrhagic Fever (DHF) in 2015, new evidence for the treatment and management of dengue have emerged. The new Singapore National Dengue Guideline, developed by NCID, provides clinicians with updated evidence-based recommendations and incorporates recent research and best practices to support dengue management in Singapore.

Asst Prof Chia Po Ying, Head of NCID Research and Senior Consultant at the Department of Infectious Disease (NCID/TTSH), who chairs the NCID-led Dengue Guidelines Workgroup, shares how these updated guidelines will support clinical decision-making and improve patient care in dengue management.

The dengue guideline has been methodologically validated by ACE as meeting ACE’s Guidelines for Guidelines (G4G) standards for high-quality clinical guideline development.

Read the guideline now at https://go.gov.sg/aceli422

07/04/2026

🌍 This World Health Day, we are reminded that better health outcomes start with good evidence.

At ACE, we review clinical evidence and conduct Health Technology Assessments (HTA) to inform healthcare decisions in Singapore — from subsidy decisions to clinical guidance.
Our work helps ensure that patients receive treatments that are safe, clinically effective and cost-effective, and that healthcare resources are used where they make the most difference.

By translating scientific evidence into action, ACE supports more accessible and affordable care for Singaporeans.

In this new series of webinars organised in collaboration with the College of Family Physicians (CFPS), join experts fro...
24/03/2026

In this new series of webinars organised in collaboration with the College of Family Physicians (CFPS), join experts from primary care and specialists from the ACE Clinical Guideline (ACG) Expert Groups as they share the latest evidence-based recommendations from recently published ACGs and discuss clinical practice considerations.
For the first session, hear more about the Osteoporosis ACG. With Singapore's ageing population, osteoporosis remains a silent threat – making timely and appropriate management key.

Register here: https://go.gov.sg/acg-osteoporosis-cfpswebinar

21/03/2026

Selamat Hari Raya Aidilfitri! 🌙

As families and communities come together in celebration, ACE wishes all who celebrate a joyful and meaningful Hari Raya.
May this festive day bring peace, reflection, and renewed spirit as we continue working together towards better care for all.

🏌Take your guidelines to the next level using ACE’s Guidelines for Guidelines (G4G)! Clinical guidelines are key knowled...
19/03/2026

🏌Take your guidelines to the next level using ACE’s Guidelines for Guidelines (G4G)!

Clinical guidelines are key knowledge instruments that consolidate evidence and deliver systematic recommendations to enhance clinical decision-making processes. The methodological rigour directly impacts the effectiveness and clinical utility of the guidelines developed. The establishment of the nine G4G standards represents a comprehensive strategic initiative to elevate local guideline development capabilities, fostering the creation of scientifically robust, high-quality clinical guidance tailored to Singapore's unique healthcare environment. These standards provide a roadmap to advance procedural transparency and provide stakeholders with comprehensive understanding of the systematic approaches and recommendation development protocols through which evidence-based clinical guidelines should be formulated.

Read more at the ACE website: https://go.gov.sg/aceli415

🔜Watch this space for more on how to apply the G4G standards!

17/03/2026

We are pleased to share that ACE has contributed a chapter to the 2nd edition of the book “Patient Involvement in Health Technology Assessment”!

Chapter 23 – “Singapore: From Stakeholder Mapping to Continuously Improving Patient Participation in HTA” - showcases how ACE has been working with patients and carers since 2022 to strengthen their involvement in Singapore's healthcare decision-making processes.

The chapter reflects our commitment to ensuring that the voices of patients and carers are meaningfully considered in health technology assessments, helping funding recommendations better reflect what truly matters to those living with health conditions.

We thank our patient organisation partners for their collaboration and partnership in advancing this important work.

Click the link to read the full chapter: https://go.gov.sg/acefb302

03/03/2026

For over a decade, Mr Semba lived with severe mitral regurgitation, a heart condition that left him breathless and limited his daily activities.

As he was not suitable for open-heart surgery, treatment options were limited.

In this issue of ACE Insights, discover how ACE’s evidence-based evaluation informed the recommendation to subsidise transcatheter mitral valve leaflet repair (TMVLR) including MitraClip — improving access to a less invasive option for eligible patients and resulting in a better quality of life.

👉 Read the full story in the latest Issue: https://go.gov.sg/acefb298

17/02/2026

🍊 This Lunar New Year, we welcome the Year of the Horse — a symbol of strength, perseverance, and progress. As we come together to celebrate unity and resilience, we look forward to a year driven by renewed energy, hope, and shared purpose.

From all of us at ACE, we wish everyone a joyous Lunar New Year.

11/02/2026

We're excited to publish a new addition to our Voices to Impact flipbook! 📖

Our latest feature showcases how members of local patient groups partnered with ACE to co-develop factsheets on treatments for type 2 diabetes, turning medical jargon into accessible information and actionable steps.

Hear from Tiwari and Pratibha as they share their experience with the co-development process.

Click the link to read the full story: go.gov.sg/ace-voices-to-impact

23/01/2026

Immunotherapy is one of the treatment options for advanced non-small cell lung cancer (NSCLC) and several immunotherapy drugs are subsidised in Singapore for this condition.

Learn more about immunotherapy drugs for advanced NSCLC in our latest factsheet: go.gov.sg/acefb295

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College Of Medicine Building, 16 College Road
Singapore
169854

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