13/11/2025
The Frank's sign, identified as a distinct diagonal earlobe crease, is a recognized clinical marker associated with an increased risk for cardiovascular disease.
It is named after Dr. Sanders T. Frank, who first described an association between this crease and an increased risk of coronary artery disease in a 1973 article in the New England Journal of Medicine.
While its presence does not definitively diagnose heart conditions, numerous studies have established a significant statistical link to coronary artery disease and myocardial infarction.
Therefore, noticing a Frank's sign should not cause alarm but should raise awareness and encourage a thorough evaluation of traditional risk factors such as hypertension, high cholesterol, and diabetes to ensure comprehensive preventive care.