
02/07/2024
20 Years of Big data: Does Multivitamins works for healthy people?
20 年的大数据 : 复合维生素对我们有用吗?
最近发表在JAMA的一项研究确定了美国成年人定期补充多种维生素(MV)与死亡风险之间的关系。
A recent study published in JAMA Network Open determined the relationship between regular multivitamin (MV) supplementation and mortality risk among United States adults.
2022年美国预防服务工作队(USPSTF)审查了随机对照试验中关于多种维生素使用和死亡风险的数据,并得出结论认为,由于随访时间短,没有足够的证据来确定风险-效益比。
The 2022 United States Preventive Services Task Force (USPSTF) examined data on multivitamin use and death risk from randomized controlled trials and concluded that owing to short follow-up duration, there is inadequate evidence to determine risk-benefit ratios.
观察性研究提供了相互矛盾的结果,多种维生素含量的差异或混杂因素可能解释了它们不同的结果。
Observational studies provide contradictory results, and differences in multivitamin content or confounding factors may explain their varied outcomes.
在目前的研究中,研究人员研究了定期服用多种维生素是否能降低成年人的死亡风险。
In the present study, researchers investigated whether regular multivitamin usage can lower death risk in the adult US population.
该研究纳入了参加前列腺癌、肺癌、结直肠癌和卵巢癌筛查(PLCO, 42,732人)试验的无慢性病史和癌症史的成年人;农业健康研究(AHS, 19660人)或美国国立卫生研究院AARP饮食与健康研究(NIH-AARP, 327732人)。
The study included adults with no previous histories of chronic medical conditions and cancer who enrolled in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening (PLCO, 42,732 individuals) trial; the Agricultural Health Study (AHS, 19,660 individuals) or the National Institutes of Health-AARP Diet and Health Study (NIH-AARP, 327,732 individuals).
参与者完成了基线调查问卷,以提供多种维生素的服用数据。
Participants completed baseline questionnaires to provide multivitamin usage data.
时变分析分别纳入了AHS、PLCO和NIH-AARP研究开始后5年、3年和9年的随访饮食问卷数据。
The time-varying analyses incorporated follow-up dietary questionnaire data five years, three years, and nine years after initiating the AHS, PLCO, and NIH-AARP studies, respectively.
该研究包括390,124人:327,732人来自NIH-AARP, 42,732人来自PLCO, 19,660人来自AHS。
The study included 390,124 individuals: 327,732 from NIH-AARP, 42,732 from PLCO, and 19,660 from AHS.
参与者的中位年龄为62岁,55%为男性。
The median participant age was 62 years, and 55% were male.
研究人员在随访期间共发现164,762人死亡;在164,762例死亡中,49,836例死于癌症,35,060例死于心血管疾病,9,275例死于脑血管疾病。
In total, the researchers noted 164,762 demises in the follow-up period; Of the 164,762 deaths, 49,836 resulted from cancer, 35,060 from cardiovascular diseases, and 9,275 from cerebrovascular diseases.
他们估计了随访前半期和后半期(即随访期1 [FP1]和随访期2 [FP2])的相对风险,
they estimated relative risks in the first and second halves of follow-up (ie, follow-up period 1 [FP1] and follow-up period 2 [FP2],
在前半期中,55岁以下的个体,定期服用多种维生素者任何原因死亡的风险更高(HR, 1.2)。
In the initial follow-up analysis (FP1), HR values for regular multivitamin usage and any-cause death were higher for individuals aged below 55 years (HR, 1.2).
荟萃分析纳入了来自所有队列的随时间变化的估计,表明与不使用相比,定期使用多种维生素与前半期的任何原因死亡风险增加4.0%相关,而与后半期无关。
The meta-analysis, incorporating time-varying estimates from all cohorts, showed that regular multivitamin usage, compared to non-usage, was related to a 4.0% higher risk of any-cause death in FP1 but not in FP2.
研究结果并没有提供经常服用多种维生素的人寿命延长的证据。
The study findings do not provide evidence of increased longevity among regular multivitamin users.
然而,不能排除定期服用复合维生素对其他与衰老相关的健康结果的可能影响。
However, one cannot rule out the possible effects of regular multivitamin usage on other aging-related health outcomes.
Journal references:
Loftfield E, O’Connell CP, Abnet CC, et al., Multivitamin Use and Mortality Risk in 3 Prospective US Cohorts. JAMA Netw Open. 2024;7(6):e2418729.
DOI: 10.1001/jamanetworkopen.2024.18729 https://jama.jamanetwork.com/article.aspx?doi=10.1001/jamanetworkopen.2024.18729