Dahai-Lab, NTU, Singapore

12/09/2021

Innate immunity might be the key to why children have fared better with the virus. But the Delta variant poses fresh unknowns.

22/05/2021

Flaviviruses are vector-borne RNA viruses, many of which are clinically relevant human viral pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever viruses. Millions of people are infected with these viruses around the world each year. Vaccines are only available for some...

16/03/2021

Chikungunya virus (CHIKV) causes a debilitating arthralgic inflammatory disease in humans. The multifunctional CHIKV protein, nsP1, facilitates virus …

05/03/2021

The drug candidate PF-00835231 is the active compound of the first anti-3CLpro regimen in clinical trials. It was developed and frozen during the SARS time...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of Coronavirus Disease 2019 (COVID-19). There is a dire need for novel effective antivirals to treat COVID-19, as the only approved direct-acting antiviral to date is remdesivir, targeting the viral polymerase comp...

04/02/2021

Hope is always there ... anti-dengue drug

Dengue virus (DENV) is a mosquito-borne flavivirus that lacks any effective antiviral treatments. There are four serotypes of DENV, all of which can cause disease, including dengue fever, dengue shock syndrome, or dengue hemorrhagic fever. Thus, an antiviral drug needs to be effective against all fo...

16/01/2021

Genome-sequencing pioneer Eric Lander of the Broad Institute became the target of venomous online attacks last week because of an essay he wrote.

16/01/2021

Herd immunity by infection is not an option: A largely unmitigated outbreak where even with an estimated 76% of the population being infected, herd immunity was not achieved.

Herd immunity is expected to arise when a virus cannot spread readily, because it encounters a population that has a level of immunity that reduces the number of individuals susceptible to infection. On page 288 of this issue, Buss et al. ([ 1 ][1]) describe the extent of the largely uncontrolled se...