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01/12/2018

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18/11/2018

*A short article on Diuretics.*

Introduction :

What is a diuretic ?

Diuretic is substance which
promotes
diuresis, that is, the increased production of urine.

*Classification of Diuretics*
To Remeber the classification Just Follow this Mnemonic

*PLOT*

P- Potassium
Sparing

L- Loop Diuretics

O- Osmotic
Diuretics

T - Thiazides

Examples :

0⃣1⃣ Potassium
Sparing :

1) Amiloride.

2) Triamterene.

3) Eplerenone.

4) Spironolactone.

Potassium
Sparing Diuretics don't deplete potassium levels from blood unlike Thiazides and Loop Diuretics, hence can be used in patients who suffer from edema and are at a risk of hypokalemia too.

0⃣2⃣ Loop Diuretics :

1) Bumetanide.

2) Ethacrynic acid.

3) Furosemide.

4) Torsemide.

Out of Furosemide and Torsemide it is seen that In cases of Cirrhosis and Ascites where Rapid fluid Removal is needed Torsemide is considered a better option than Furosemide.

Also we can say that Torsemide is a much potential diuretic than Furosemide although both are loop Diuretics.

0⃣3⃣ Osmotic Diuretics :

1) Mannitol.

2) Urea.

3) Glycerine.

4) IsoSorbide.

0⃣4⃣ Thiazides :

1) Chlorothiazide.

2) Chlorthalidone.

3) Hydrochlorothiazide.

*Some Clinically Relevant Points*

1) Out of the 4 classes of Diuretics The most potent is Loop Diuretic.

Second is the Thiazide
Third one is Potassium
Sparing.

And most weakest is The Osmotic Diuretics.

*Important Question :*

Why Thiazides causes Hypercalcemia while Loop Diuretics Causes Hypocalcemia ?

Answer :

The mechanism of how Thiazide causes Hypercalcemia is illustrated as below ↩

Thiazides exert their anti hypertensive effect through an increase in sodium excretion by blocking the thiazide -sensitive NaCl transporter in the Distal convoluted tubule, which is closely linked to calcium transport.

Thiazides have several metabolic effects contributing to higher serum calcium levels, but increased renal tubular reabsorption of calcium resulting in reduced urine calcium excretion which causes rise in Serum calcium concentrations.

While loop diuretics induce natriuresis by inhibiting the Na-K-2Cl transporter in the Thick ascending limb of the loop of Henle, causing increased urinary calcium loss.

*Thus we have seen that Thiazides works on DCT i.e Distal Convulated Tubules and Increases Calcium Absorbtion.*

*While Loop Diuretics work on Thick Ascending Loop Of Henle and lead to Increased Urinary Calcium loss*

*Second Clinically Relevant Point :*

Comparison between
Thiazides and Loop Diuretics

Out of Loop Diuretics and Thiazides
If we want to compare the pros and cons of administering them we will come across the following points

1) Thiazides are given in patients who have a history of osteoporosis and hypocalcemia.

Also Thiazides are known to play a role in Osteoblast activity thus increases the Calcium absorption in blood and makes bones stronger.

2) One more important role of Thiazide is that it helps in the prevention of calcium stones and also helps in Treatment of Kidney stones where idiopathic Hypercalcemia is seen.

*The down side or Cons of Using Thiazides are :*

Thiazides are not used in following 5 conditions.

1) Patient with Poor Renal functions.

2) Pt. Having Gout.

3) SEVERE Diabetic.

4) Thiazides are also linked to vision problems.

5) Patients Allergic to Sulpha class of drugs.

*As Thiazides can flare up Gouts attack and Can cause Insulin Resistance*

*Clinical Indication of Loop Diuretics :*

Loop Diuretics being most potent class of Diuretics could be used in the following :

1) Pt with Poor Renal functions.

2) Pt with Gouts.

3) Pt with Known Diabetes.

*Only Cons for using Loop Diuretic is Osteoporosis*

*Pt who have severe Osteoporosis should not be prescribed Loop Diuretics as They can further deplete the Calcium levels in body*

TRICK TO REMEMBER THIS

*LOST*

*LOOP DIURETUCS CAUSES OSTEOPOROSIS*🐤

Hope you all liked this short clinical Insight into Diuretics.

Thanks and Regards.

01/11/2018

A season of joy and prosperity to all 🙏

11/08/2018
07/08/2018

💯💯💯Important points ✈✈✈✈✈

*.Pulmonary *Tuberculosis (PTB)* —low-gradeafternoon fever.

*. *Pneumonia* —rust-colored sputum.

*.Asthma*—wheezing on expiration.

*.Emphysema*—barrel chest.

*.Kawasaki Syndrome*—strawberry tongue.

*.Pernicious Anemia*—red beefy tongue.

*.Down syndrome*—protruding tongue.

*.Cholera*—rice-watery stool and washer woman’s hands (wrinkled hands from dehydration).

*.Malaria*—stepladder like fever with chills.

*.Typhoid*—rose spots in the abdomen.

*.Dengue*—fever,rash, and headache. Positive Herman’s sign.

*.Diphtheria*—pseudomembrane formation.

*.Measles*—Koplik’s spots (clustered white lesions on buccal mucosa).

*.Systemic Lupus Erythematosus*—butterfly rash.

*.Leprosy*—leonine facies (thickened folded facial skin).

*.Bulimia*—chipmunk facies (parotid gland swelling).

*.Appendicitis*—rebound tenderness at McBurney’s point.

Rovsing’s sign (palpation of LLQ elicits pain in RLQ). Psoas sign (pain from flexing the thigh to the hip).

*.Meningitis*—Kernig’s sign (stiffness of hamstrings causing inability to straighten the leg when the hip is flexed to 90 degrees),

Brudzinski’s sign (forced flexion of the neck elicits a reflex flexion of the hips).

*.Tetany*—hypocalcemia, [+] Trousseau’s sign; Chvostek sign.

*.Tetanus*— Risus sardonicus or rictus grin.

*.Pancreatitis*—Cullen’s sign (ecchymosis of the umbilicus), Grey Turner’s sign (bruising of the flank).

*.Pyloric Stenosis*—olive like mass.

*.Patent Ductus Arteriosus*—washing machine-like murmur.

*.Addison’s disease*—bronzelike skin pigmentation.

*.Cushing’s syndrome*—moon face appearance and buffalo hump.

*.Grave’s Disease (Hyperthyroidism)*—Exophthalmos(bulging of the eye out of the orbit).

*.Intussusception—Sausage*-shaped mass.

*.Multiple Sclerosis*—Charcot’s Triad: nystagmus, intention tremor, and dysarthria.

*.Myasthenia Gravis*—descending muscle weakness, ptosis (drooping of eyelids).

*.Guillain-Barre Syndrome*—ascending muscles weakness.

*.Deep vein thrombosis (DVT)*—Homan’s Sign.

*.Angina*—crushing, stabbing pain relieved by NTG.

*.Myocardial Infarction (MI)*—crushing, stabbing pain radiating to left shoulder, neck, and arms. Unrelieved by NTG.

*.Parkinson’s disease*—pill-rolling tremors.

*.Cytomegalovirus (CMV) infection*—Owl’seye appearance of cells (huge nucleus in cells).

*.Glaucoma*—tunnel vision.

*.Retinal Detachment*—flashes of light, shadow with curtain across vision.

*.Basilar Skull Fracture*—Raccoon eyes (periorbital ecchymosis) and Battle’s sign (mastoid ecchymosis).

*.Buerger’s Disease*—intermittent claudication (pain at buttocks or legs from poor circulation resulting in impaired walking).

*.Diabetic Ketoacidosis*—acetone breathe.

*.Pregnancy Induced Hypertension (PIH)*—proteinuria, hypertension, edema.

*.Diabetes Mellitus*—polydipsia, polyphagia, polyuria.

*.Gastroesophageal Reflux Disease (GERD)*—heartburn.

*.Hirschsprung’s Disease (Toxic Megacolon)*—ribbon-like stool.

*.Sexual Transmitted Infections:*

*.Herpes Simplex Type Il*—painful vesicles on genitalia

*.Ge***al Warts*—warts 1-2 mm in diameter.

*.Syphilis*—painless chancres.

*.Chancroid*—painful chancres.

*.Gonorrhea*—green, creamy discharges and painful urination.

*.Chlamydia*—milky discharge and painful urination.

*.Candidiasis*—white cheesy odorless vaginal discharges.

*.Trichomoniasis*—yellow, itchy, frothy, and foul-smelling vaginal discharges.

Faa-idooyiinka iyo Waxtarka uu Tufaaxa leeyahay…..
29/06/2018

Faa-idooyiinka iyo Waxtarka uu Tufaaxa leeyahay…..

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fadlan iska joojo sigaarka|dhibaato ayuu ugeesta aadamaha

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