17/05/2025
Cancer Research, new study from Sakon Nakon, Thailand.
Thailand, explores the potential of Squirrel Tail cannabis (CLE) in fighting cholangiocarcinoma (CCA), a deadly bile duct cancer prevalent in Northeast Thailand.
With over 10,000 annual deaths, CCA is a major health challenge, but this local herb may assist.
CLE’s high phenolic and flavonoid content shows strong antioxidant activity.
Cannabinol (CBN) can stop CCA cancer cells from growing. It works well, with a small amount (as low as 4.00 µM) being effective after 72 hours.
CLE helps kill cancer cells by increasing proteins that promote cell death (p53, caspase-3, and Bax) and decreasing a protein that helps cancer cells survive (Bcl-2).
Formulation included, Flowers of female plants, Roots, Leaves, and Stems. These parts are used in formulations listed in Thailand’s National List of Essential Medicines, particularly for cancer patients, due to their bioactive compounds like cannabinoids (THC, CBD, CBN), terpenoids, flavonoids, and phenolic compounds.
This research highlights Squirrel Tail cannabis, a traditional Thai medicine, as a promising anti-cancer agent.
While more clinical trials are needed, these findings could pave the way for innovative, natural therapies for cancer patients.
Departments at Rajamangala University of Technology Isan, Sakon Nakhon Campus (47160), and Khon Kaen University, Khon Kaen (40002), Thailand:
Thai Traditional Medicine, Faculty of Natural Resources, Sakon Nakhon
Parasitology and Cholangiocarcinoma Research Institute (CARI), Faculty of Medicine, Khon Kaen
“Raw data doesn’t lie, even the most hardened cannabis critics can’t contest”
Truong M Nguyen
Supporting Science and Researchers to secure the data needed to unlock beneficial botanicals human healths potential.
May 15, 2025
Link to Study below ⬇️
Impact of Cannabis Leaf (Sakon Nakhon Cultivar) Extracts on Anti-Cholangiocarcinoma Activity.
https://www.sciencedirect.com/science/article/abs/pii/S2210803325000399