Thai Breast Disease Society

10/02/2026

In female BRCA1/2 pathogenic variant carriers without prior breast cancer, risk-reducing bilateral mastectomy was associated with significantly lower overall and breast cancer–specific mortality, supporting its potential life-extending benefit.

This systematic review and meta-analysis investigates the association between risk-reducing bilateral mastectomy and mortality in carriers of the BRCA1 and BRCA2 gene variants.

10/02/2026

In a select cohort of patients with de novo oligometastatic breast cancer treated with curative intent, multimodality therapy was associated with favorable long-term survival, though optimal management strategies remain uncertain.

Purpose De novo oligometastatic breast cancer (OMBC) is often defined as up to five metastases in two or fewer organs at presentation. Studies have suggested favorable outcomes for patients with OMBC; however, management remains controversial. We analyzed outcomes of patients with de novo OMBC treat...

10/02/2026

A new study in The Oncologist finds that chemotherapy significantly improves overall survival for patients with lymph node-negative invasive papillary breast cancer who have tumors larger than 2 cm or high-grade disease.

AbstractBackground. Invasive papillary breast cancer (IPC) is a rare cancer known to have a better prognosis than other breast cancers. This study aimed to

10/02/2026

A new study in The Oncologist finds that neoadjuvant endocrine therapy combined with CDK4/6 inhibitors is as effective as traditional chemotherapy for treating locally advanced hormone receptor-positive breast cancer, offering a potential chemotherapy-free option with favorable outcomes.

AbstractBackground. Neoadjuvant treatment for hormone receptor (HR)-positive breast cancer remains limited, particularly for tumours that are insensitive t

10/02/2026

A new study in Quantitative Imaging in Medicine and Surgery identifies tumor size greater than 20 mm and abnormal ultrasound findings as the most significant risk factors for predicting axillary lymph node metastasis in invasive breast cancer.

Correlations of ultrasound features and immunohistochemical indicators with axillary lymph node metastasis in invasive breast cancer

10/02/2026

A new study in Surgical Oncology finds that 43% of breast cancer patients with a positive sentinel lymph node after neoadjuvant chemotherapy have additional metastatic nodes, identifying extranodal extension as the key predictor for further disease.

03/02/2026

In an observational cohort study published in JAMA Network Open, Bodelon et al examined whether inherited susceptibility to excess body weight influences long-term survival among breast cancer survivors. Using a polygenic score for body mass index (BMI), the investigators sought to determine whether a genetic predisposition to higher body weight contributes to mortality risk independent of measured BMI and whether modifiable behaviors such as walking might mitigate this inherited risk.

This cohort study investigates whether there is an association between a genetic predisposition to a greater body mass index and mortality risk among US women who survived nonmetastatic breast cancer.

03/02/2026

Recreational physical activity may be associated with breast tissue composition and oxidative stress levels in adolescent girls, independent of body fat percentages, according to research findings published in Breast Cancer Research.

Evidence suggests that recreational physical activity (RPA) during adolescence is associated with lower breast cancer (BC) risk, but the biological mechani

03/02/2026

A clinical study investigating the prognostic role of circulating tumor DNA (ctDNA) and its utility in guiding adjuvant therapy for HER2-positive early breast cancer has found that patients who test positive for the presence of ctDNA after they have received neoadjuvant treatment and surgery have worse outcomes than patients who are negative for ctDNA—even in patients who experienced a pathologic complete response. The findings demonstrate that ctDNA is an independent prognostic factor and may serve as an additional marker for guiding adjuvant therapy with ado-trastuzumab emtansine (T-DM1). The study by Lin et al was published in Cancer Research Communications.

AbstractctDNA has been reported as a predictor of the progression of metastatic breast cancer and recurrence in early breast cancer (EBC). This study explored whether ctDNA persistence in patients with HER2-positive (HER2+) EBC who achieved pathologic complete response (pCR) after neoadjuvant therap...

03/02/2026

In an initial analysis of a retrospective cohort study (OPBC-07/microNAC) reported in The Lancet Oncology, Montagna et al found that available evidence did not provide support for axillary lymph node dissection (ALND) in all patients with ypN1mi disease in sentinel lymph nodes after neoadjuvant chemotherapy for breast cancer.

03/02/2026

In a Chinese phase III trial (RJBC 1501) reported in the Journal of Clinical Oncology, Chen et al found that the addition of carboplatin to adjuvant epirubicin plus cyclophosphamide followed by taxane chemotherapy significantly improved disease-free survival in patients with early-stage triple-negative breast cancer (TNBC).

PURPOSETo evaluate the efficacy and safety of adjuvant epirubicin plus cyclophosphamide followed by taxanes (EC-T) versus EC-T plus carboplatin (EC-TCb) in patients with early-stage triple-negative breast cancer (TNBC).PATIENTS AND METHODSIn this phase ...

03/02/2026

In a cohort study analysis reported in the Journal of Clinical Oncology, Valenza et al found that extended endocrine therapy after 5 years of adjuvant luteinizing hormone–releasing hormone agonist (LHRHa) treatment was associated with benefit among premenopausal women with node-positive, hormone receptor–positive breast cancer.

PURPOSETo evaluate the clinical benefit of extended endocrine therapy (eET) after 5 years of adjuvant treatment with luteinizing hormone-releasing hormone agonists (LHRHa) in premenopausal women with node-positive, hormone receptor–positive early breast ...