17/02/2025
Our CE most recent work in mimicking oral mucositis in a milifluidic MPS platform was just published at the Engineered Regeneration journal (ranked 7/303 in Biomedical Eng, Citescore 22.9). Here are the HIGHLIGHTS of our work:
• Magnetic 3D bioassembly or bioprinting can promptly produce physiologically relevant multi-layered oral epithelial sheets from human oral keratinocytes.
• Our dynamic millifluidic system can generate an oral mucositis (OM) disease model within an organ-on-a-chip from bioprinted oral epithelium after 5-fluorouracil (5FU) chemotherapy drug perfusion.
• This millifluidic system was meaningful to confirm the effects of our in-house plant-produced EGF towards the promotion of epithelial migration in wound healing, mitigation of oxidative stress and reduction of DNA damage on the bioengineerined OM-on-a-chip in the presence of Fusobacterium nucleatum (Fn), an OM-associated pathogen.
• P-EGF may constitute a promising therapeutic modality to quickly promote oral re-epithelialization and wound healing.
Our many thanks to Tien Truong, Toan Van Phan, Yamin Oo, Oranart Matangkasombut, Glauco Souza, Silvia Scaglione, Maurizio Aiello, React4life, Waranyoo Pang Phoolcharoen (Baiya Phytopharm), Supansa Yodmuang, Faculty of Dentistry, Chulalongkorn University, NUS Faculty of Dentistry and many others for coming together to support this project! Also, thank you to our funders, in particular the International Association for Dental, Oral, and Craniofacial Research and their 2022 Innovation in Oral Care Award! Enjoy the read of this pre-proof version online:
