12/02/2025
Japanese research indicates that IV NMN injections can lower blood lipid levels in healthy individuals (safely and effectively injecting NMN into healthy people can reduce blood lipid (triglyceride) levels and increase NAD+ levels).
Highlights
• A single IV NMN DRIP can reduce blood lipid levels by approximately 75%.
• NMN injection can be metabolized safely; despite bypassing the body's detoxifier—the liver—it does not cause significant damage to the heart, kidneys, or pancreas.
• Injection raises blood NAD+ levels by about 20%.
When injected directly into the bloodstream, IV NMN bypasses the liver, the body's central detoxifier. There is growing concern that without liver filtration, IV NMN could potentially harm the heart, pancreas, and/or kidneys.
Published in Cureus, researchers Gotoh and colleagues from Hyogo Medical University in Japan demonstrated that NMN can be safely metabolized when injected and significantly reduce blood lipid (triglyceride) levels. Additionally, IV NMN injections significantly boosted blood levels of the longevity molecule nicotinamide adenine dinucleotide (NAD+). Interestingly, to date, no other human studies have shown that NMN lowers blood triglyceride levels, possibly due to the use of oral supplements. These findings suggest that NMN injections can be safely metabolized and may help lower blood triglyceride levels.
NMN injections reduce blood lipids and increase NAD+.
To measure the metabolic benefits of NMN injections, Gotoh and colleagues administered 300 milligrams of NMN intravenously to ten healthy individuals (ages 20-70) and conducted blood analyses. While NMN injection had no effect on cholesterol, it reduced blood triglycerides by approximately 75% (dropping from ~80 mg/dL to ~20 mg/dL three hours post-injection). No studies using oral NMN administration have shown a decrease in triglyceride levels, indicating that NMN injections have unique benefits. Elevated triglyceride levels are associated with fatty liver disease and Type II diabetes, suggesting that NMN injections may offer a method to combat these age-related diseases.
