10/03/2026
"Although ketamine has shown rapid antidepressant effects in patients with treatment-resistant depression, its molecular mechanism in the human brain has remained unclear"
https://www.technologynetworks.com/drug-discovery/news/ketamines-fast-antidepressant-effects-tracked-with-brain-imaging-410465?fbclid=IwdGRjcAQde_5jbGNrBB17m2V4dG4DYWVtAjExAHNydGMGYXBwX2lkDDM1MDY4NTUzMTcyOAABHv95MBrgJPH-y9ZfTn1qgY6pbFn7dfGJ_DtTk_iB7BXwFF3KN-OzQGdeABWB_aem_CZ_Vy8fx685yAmv86vxU4g
Researchers used a novel PET tracer to visualize how ketamine alters AMPA receptor distribution in the brains of patients with treatment-resistant depression. Receptor density increased in cortical regions and decreased in reward-related regions.