邱德生醫師的腫瘤粉專

邱德生醫師的腫瘤粉專 治療癌症、預防癌症
(1)

感謝🙏付出時間、精力盼望🙏能有改變、改善
06/09/2025

感謝🙏付出時間、精力
盼望🙏能有改變、改善

子宮次全切除手術(又稱子宮頸上切除術、supracervical hysterectomy)是指僅切除子宮體,保留子宮頸的手術方式。常見的手術途徑包括腹腔鏡、腹部或陰道途徑。[1][2][3]    手術方法:  1. 腹腔鏡(含  #達文...
06/09/2025

子宮次全切除手術(又稱子宮頸上切除術、supracervical hysterectomy)是指僅切除子宮體,保留子宮頸的手術方式。常見的手術途徑包括腹腔鏡、腹部或陰道途徑。[1][2][3]

手術方法:
1. 腹腔鏡(含 #達文西)次全子宮切除術:經腹腔鏡分離子宮體與子宮頸交界處,切除子宮體,保留子宮頸,最後縫合切口。[1]

2. 腹部次全子宮切除術:經腹部切口,分離子宮體與子宮頸,切除子宮體,保留子宮頸。[4]

3. 陰道次全子宮切除術:經陰道途徑切除子宮體,保留子宮頸,適用於部分解剖條件良好的患者。[3]

優點:
- 手術時間較短、失血量較少:多項隨機對照試驗及系統性回顧顯示,次全切除術的手術時間及術中失血量均較全子宮切除術少。[5][6][4][7]

- 術後住院天數較短、發熱及尿潴留等短期併發症較少。[5][6][4]

- 理論上降低鄰近器官損傷(如尿道、膀胱、輸尿管)風險。[1][8]

- 部分文獻認為可減少骨盆器官脫垂風險,但證據有限仍待進一步研究。[1][7]

缺點:
- 術後仍可能有週期性少量陰道出血(約7-14%),因子宮頸殘留內膜組織。[5][6][4][7]

- 需持續子宮頸癌篩檢,因子宮頸仍在。[9][4]

- 子宮頸殘端可能發生感染、出血或罹患子宮頸癌。[7][8]

目前醫學文獻認為,子宮次全切除術的主要優點是手術時間短、失血少、短期併發症低,但需考慮術後週期性點狀出血及子宮頸癌風險。選擇手術方式時,應根據患者解剖條件、疾病特性及個人需求綜合考量。[5][6][1][4][7][3]

References
1. Laparoscopic Subtotal Hysterectomy: Evidence and Techniques. Nesbitt-Hawes EM, Maley PE, Won HR, et al. Journal of Minimally Invasive Gynecology. 2013 Jul-Aug;20(4):424-34. doi:10.1016/j.jmig.2013.01.009.
2. A New Technique for Supracervical Hysterectomy: Anterograde Vaginal Subtotal Hysterectomy. Li ZJ, Jia ZX, Zheng YQ. Medicine. 2020;99(21):e20006. doi:10.1097/MD.0000000000020006.
3. Subtotal Hysterectomy and Myomectomy - Vaginally. Thomas B, Magos A. Best Practice & Research. Clinical Obstetrics & Gynaecology. 2011;25(2):133-52. doi:10.1016/j.bpobgyn.2010.11.003.
4. Outcomes after Total versus Subtotal Abdominal Hysterectomy. Thakar R, Ayers S, Clarkson P, Stanton S, Manyonda I. The New England Journal of Medicine. 2002;347(17):1318-25. doi:10.1056/NEJMoa013336.
5. Total Versus Subtotal Hysterectomy for Benign Gynaecological Conditions. Lethaby A, Mukhopadhyay A, Naik R. The Cochrane Database of Systematic Reviews. 2012;(4):CD004993. doi:10.1002/14651858.CD004993.pub3.
6. Total Versus Subtotal Hysterectomy: Systematic Review and Meta-Analysis of Intraoperative Outcomes and Postoperative Short-Term Events. Aleixo GF, Fonseca MCM, Bortolini MAT, Brito LGO, Castro RA. Clinical Therapeutics. 2019;41(4):768-789. doi:10.1016/j.clinthera.2019.02.006.
7. Total or Subtotal Hysterectomy for Benign Uterine Diseases? A Meta-Analysis. Gimbel H. Acta Obstetricia Et Gynecologica Scandinavica. 2007;86(2):133-44. doi:10.1080/00016340601024716.
8. Subtotal Hysterectomy in Modern Gynecology: A Decision Analysis. Scott JR, Sharp HT, Dodson MK, Norton PA, Warner HR. American Journal of Obstetrics and Gynecology. 1997;176(6):1186-91; discussion 1191-2. doi:10.1016/s0002-9378(97)70333-8.
9. Supracervical Hysterectomy: ... A Time for Reappraisal. Munro MG. Obstetrics and Gynecology. 1997;89(1):133-9. doi:10.1016/s0029-7844(96)00295-5.

💰💔 你聽過「財務毒性」嗎?在醫療裡,毒性通常指藥物的副作用。但「財務毒性(Financial Toxicity)」指的卻是——治療帶來的經濟壓力。📌 什麼是財務毒性?當一個人罹患癌症或慢性病,除了身體要承受治療的辛苦,往往還要面對龐大的醫...
05/09/2025

💰💔 你聽過「財務毒性」嗎?
在醫療裡,毒性通常指藥物的副作用。
但「財務毒性(Financial Toxicity)」指的卻是——治療帶來的經濟壓力。

📌 什麼是財務毒性?
當一個人罹患癌症或慢性病,除了身體要承受治療的辛苦,往往還要面對龐大的醫療費用。這些花費包括:
• 治療費、藥物費、住院費
• 交通、住宿、營養品
• 甚至因請假或失去工作而減少收入

這種壓力,會讓病人和家庭感覺「錢快要把人壓垮了」,就像一種看不見的毒素。

📌 為什麼重要?
研究發現,財務毒性不只影響生活品質,甚至會讓一些病人:
• 延遲治療
• 減少藥物劑量
• 甚至中斷醫療
而這都可能影響到病情控制與存活率。

📌 我們能怎麼辦?
🌱 醫師與醫療團隊:需要更多關心病人經濟狀況,協助轉介社工或財務支援。
🌱 政府與社會:應該提供合理的健保、補助與藥物給付。
🌱 病人與家屬:可以事先規劃保險、財務,勇敢開口和醫療團隊討論困難。

✨ 財務毒性不是病人的錯,它是我們社會需要一起面對的挑戰。
讓醫療不只治癒身體,也能減輕經濟的重擔。

#財務毒性 #醫病同行 #看不見的副作用

toxicity is the term used to describe the adverse impact of the costs associated with medical care—most notably cancer care—on a patient's financial well-being. It encompasses both the objective financial burden (such as out-of-pocket expenses, medical debt, and loss of income due to illness) and the subjective financial distress (including psychological stress and anxiety related to financial strain) that patients and their families experience as a result of diagnosis and treatment.[1][2][3][4][5][6][7][8][9][10]

Financial toxicity manifests in three domains: material hardship (e.g., inability to pay bills or afford necessities), psychological distress (e.g., anxiety, depression related to financial strain), and behavioral coping (e.g., delaying or foregoing recommended care due to cost).[3][4][8][10] It is associated with negative clinical outcomes, including decreased quality of life, impaired adherence to treatment, and even increased mortality risk.[5][6][7][9][10] Risk factors include lower income, lack of social support, advanced disease stage, and employment changes due to illness.[8][10]

Validated tools such as the COmprehensive Score for financial Toxicity (COST) are used to assess financial toxicity in clinical practice.[5] Addressing financial toxicity requires multidisciplinary interventions, including financial navigation, counseling, and policy-level changes to reduce patient burden.[1][2][3][8]

References

1. Navigating Financial Toxicity in Patients With Cancer: A Multidisciplinary Management Approach. Smith GL, Banegas MP, Acquati C, et al. CA: A Cancer Journal for Clinicians. 2022;72(5):437-453. doi:10.3322/caac.21730.
2. Financial Toxicity in Cancer Care: Implications for Clinical Care and Potential Practice Solutions. Khan HM, Ramsey S, Shankaran V. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 2023;41(16):3051-3058. doi:10.1200/JCO.22.01799.
3. Financial Toxicity: A Practical Review for Gynecologic Oncology Teams to Understand and Address Patient-Level Financial Burdens. Liang MI, Harrison R, Aviki EM, et al. Gynecologic Oncology. 2023;170:317-327. doi:10.1016/j.ygyno.2023.01.035.
4. Financial Toxicity in Cancer Care: Prevalence, Causes, Consequences, and Reduction Strategies. Lentz R, Benson AB, Kircher S. Journal of Surgical Oncology. 2019;120(1):85-92. doi:10.1002/jso.25374.
5. Financial Toxicity in Lung Cancer. Boulanger M, Mitchell C, Zhong J, Hsu M. Frontiers in Oncology. 2022;12:1004102. doi:10.3389/fonc.2022.1004102.
6. The Financial Burden and Distress of Patients With Cancer: Understanding and Stepping-Up Action on the Financial Toxicity of Cancer Treatment. Carrera PM, Kantarjian HM, Blinder VS. CA: A Cancer Journal for Clinicians. 2018;68(2):153-165. doi:10.3322/caac.21443.
7. Assessment of Financial Toxicity Among Older Adults With Advanced Cancer. Arastu A, Patel A, Mohile SG, et al. JAMA Network Open. 2020;3(12):e2025810. doi:10.1001/jamanetworkopen.2020.25810.
8. Financial Toxicity in Older Adults With Cancer and Their Caregivers. Kadambi S, Wang Y, Job A, et al. JCO Oncology Practice. 2025;21(1):92-99. doi:10.1200/OP.24.00105.
9. Financial Toxicity in Patients With Leukemia Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review. Pail O, Knight TG. Best Practice & Research. Clinical Haematology. 2023;36(2):101469. doi:10.1016/j.beha.2023.101469.
10. Financial Toxicity in Patients With Resected Lung Cancer. Deboever N, Eisenberg M, Hofstetter WL, et al. Annals of Surgery. 2023;278(6):1038-1044. doi:10.1097/SLA.0000000000005926.

半年前子宮鏡冷刀清除內膜病灶後,病患回診升格為「孕婦」、「準媽媽」:此處指的是以冷刀(非電燒)方式進行子宮鏡下內膜病灶(如息肉、黏膜下肌瘤、黏連等)切除。冷刀技術主要優點在於避免電熱損傷,理論上有助於保護正常子宮內膜,減少術後黏連,對於有生...
01/09/2025

半年前子宮鏡冷刀清除內膜病灶後,病患回診升格為「孕婦」、「準媽媽」:

此處指的是以冷刀(非電燒)方式進行子宮鏡下內膜病灶(如息肉、黏膜下肌瘤、黏連等)切除。冷刀技術主要優點在於避免電熱損傷,理論上有助於保護正常子宮內膜,減少術後黏連,對於有生育需求的患者尤為重要。[1][2]

根據最新的臨床研究,在 #有明確子宮腔病灶(如息肉、黏膜下肌瘤、黏連)且有生育需求的患者,子宮鏡下切除病灶後,懷孕率確實有提升。例如,針對息肉或肌瘤,冷刀切除可減少殘留病灶與二次手術機率,且不會造成電熱損傷,術後懷孕率有提升趨勢,但目前尚無大規模隨機對照試驗證實冷刀優於電燒在懷孕率上的統計學顯著差異。針對子宮腔黏連, #冷刀分離合併預防黏連措施(如IUD、透明質酸凝膠)可顯著提升術後懷孕率與活產率。[1][2]

需要強調的是,只有在有明確子宮腔病灶且影響生育的情況下,手術才有助於提升懷孕機率。若無明確病灶,單純清除正常內膜並不被建議,反而可能增加黏連風險,影響生育。[3][4][5]

總結:有明確子宮腔病灶且有生育需求者,子宮鏡冷刀清除病灶後,懷孕通常會更順利,但需依據個人病情選擇適合的手術方式,並搭配黏連預防措施以達最佳生育結局。[1][2]

References

1. Comparison of Surgical and Postoperative Pregnancy Outcomes Between Electrotomy and Cold Instruments for Hysteroscopic Myomectomy: A Single-Center, 3-Year Retrospective Study. Chen P, Shao D, Zhao W, et al. Archives of Gynecology and Obstetrics. 2025;:10.1007/s00404-025-08131-2. doi:10.1007/s00404-025-08131-2.
2. Comparison of Secondary Prevention Following Hysteroscopic Adhesiolysis in the Improvement of Reproductive Outcomes: A Retrospective Cohort Study. Wu T, Fang T, D**g Y, et al. Journal of Clinical Medicine. 2023;13(1):73. doi:10.3390/jcm13010073.
3. Hysteroscopy for Treating Subfertility Associated With Suspected Major Uterine Cavity Abnormalities. Bosteels J, van Wessel S, Weyers S, et al. The Cochrane Database of Systematic Reviews. 2018;12:CD009461. doi:10.1002/14651858.CD009461.pub4.
4. The Effectiveness of Hysteroscopy in Improving Pregnancy Rates in Subfertile Women Without Other Gynaecological Symptoms: A Systematic Review. Bosteels J, Weyers S, Puttemans P, et al. Human Reproduction Update. 2010 Jan-Feb;16(1):1-11. doi:10.1093/humupd/dmp033.
5. Hysteroscopic Resection of Endometrial Polyps and Assisted Reproductive Technology Pregnancy Outcomes Compared With No Treatment: A Systematic Review. Zhang H, He X, Tian W, Song X, Zhang H. Journal of Minimally Invasive Gynecology. 2019 May - Jun;26(4):618-627. doi:10.1016/j.jmig.2018.10.024.

🌿【癌症,不只病人需要關心】🌿談到癌症,我們的目光幾乎都集中在病人身上。這是應該的,因為病人是直接的「受害者」,承受身體的痛苦與生命的威脅。但今天,我想談談另一群人── #癌症病人的家屬。長期與癌症共處的家屬,往往被忽略。其實,他們承受的壓...
29/08/2025

🌿【癌症,不只病人需要關心】🌿

談到癌症,我們的目光幾乎都集中在病人身上。這是應該的,因為病人是直接的「受害者」,承受身體的痛苦與生命的威脅。
但今天,我想談談另一群人── #癌症病人的家屬。

長期與癌症共處的家屬,往往被忽略。其實,他們承受的壓力,一點也不輕:

1️⃣ 精神的累
長期照顧病人,家屬很容易精神緊繃,壓力卻沒有出口。久而久之,可能變得焦躁甚至自責。尤其是父母面對罹癌的孩子,那種無法替代的心痛,更是難以言喻。

2️⃣ 身體的累
陪伴治療、日夜照護、奔波醫院,加上長期睡眠不足與精神緊張,往往讓家屬的健康也亮起紅燈。

3️⃣ 經濟的累
治療所需的費用,對多數家庭來說都是沉重的負擔。經濟壓力又會加劇精神壓力,最後也影響身體健康。

三種壓力交疊,癌症病人的家屬其實同樣是「隱形病人」。
他們需要理解、需要支持──來自社會、社區、醫護,還有親友的支持。

💌 如果你身邊有癌症病人的家屬,或許一句「你也要保重自己」的提醒,就是最溫暖的力量。
而身為家屬的你,也別忘了對自己多一份關愛。

#癌症關懷 #家屬的辛苦 #別忘了他們

門診接連二位癌友抽血報告「不及格」:血小板低下,不能如期進行化學治療。 科普衛教癌友與家人⋯⋯七大重點摘要 1. 常見併發症 #化療引起的血小板減少(chemotherapy-induced thrombocytopenia, CIT)在非...
28/08/2025

門診接連二位癌友抽血報告「不及格」:血小板低下,不能如期進行化學治療。

科普衛教癌友與家人⋯⋯
七大重點摘要
1. 常見併發症
#化療引起的血小板減少(chemotherapy-induced thrombocytopenia, CIT)在非血液惡性腫瘤患者中 #非常普遍,影響程度與患者年齡、腫瘤類型、既往化療次數與骨髓腫瘤浸潤程度有關 。
2. 與化療方案強度相關
含有順鉑(platinum)、吉西他賓(gemcitabine)或替莫唑胺(temozolomide)的療程最容易導致 CIT 。
3. 出血與輸血風險
出血情況通常僅出現在血小板計數 #低於25 × 10⁹/L的患者,此時才可能需要輸血。而 #70 × 10⁹/L以下的血小板數仍具挑戰性,需密切監測 。
4. #排除其他原因
在診斷 CIT 前,應先排除其他可能引起血小板低的原因,包括藥物副作用、感染、血栓性微血管病變、輸血後紫斑、凝血異常或免疫性血小板減少等 。
5. 減少化療強度的代價
一旦調降化療劑量或中斷治療,雖可避免 CIT,但也 #會降低腫瘤反應率與緩解機率 。
6. TPO 促進劑的作用
血小板生成素受體促進劑(包括 rhTPO、PEG-rhMGDF、romiplostim、eltrombopag、avatrombopag、hetrombopag)能改善血小板基線與谷值、減少輸血需求,並可維持化療劑量強度 。使用尚待更多證據支持
國家綜合癌症網絡(NCCN)雖允許使用這些藥物,但缺乏足夠的三期隨機試驗來證實其可減少輸血、減少化療劑量調整、及是否能改善存活率等指標。未來使用仍需依腫瘤學社群共識判斷與個案情況評估 。

7: 西醫不行,中醫可以試試。
一項隨機、雙盲、安慰劑對照研究以評估中藥提升血小板處方(CGEP) 用於治療因化學治療引起血小板減少的婦科腫瘤患者的療效研究 2015/4/20 吳宜鴻中醫師

33歲患者被診斷為第四期(IV期)肺腺癌,主要原因在於  #年輕肺腺癌患者(≤35歲)在初診時晚期比例顯著較高,且腫瘤常見遠處轉移(如胸膜、骨、腦等器官)。這一現象與腫瘤的生物學侵襲性強、潛伏期短有關,導致臨床表現時已屬晚期。[1][2][...
25/08/2025

33歲患者被診斷為第四期(IV期)肺腺癌,主要原因在於 #年輕肺腺癌患者(≤35歲)在初診時晚期比例顯著較高,且腫瘤常見遠處轉移(如胸膜、骨、腦等器官)。這一現象與腫瘤的生物學侵襲性強、潛伏期短有關,導致臨床表現時已屬晚期。[1][2][3][4][5][6]

分子層面,年輕患者肺腺癌具有高比例的驅動基因突變,包括表皮生長因子受體(EGFR)、間變性淋巴瘤激酶(ALK)、ROS1、ERBB2等。這些基因異常促進腫瘤快速進展與轉移,且年輕患者多為 #女性或無吸菸史,與腫瘤分子特徵密切相關。此外, #女性荷爾蒙 狀態亦被認為可能增加年輕女性罹患肺腺癌的風險。[1][3][8][9]

總結來說,年輕肺腺癌患者因腫瘤生物學特性(高侵襲性、潛伏期短)、分子驅動基因突變比例高、女性及無吸菸史比例高,導致初診時即有遠處轉移,晚期(IV期)比例明顯高於年長患者。[1][2][3][4][5][6-9]

References

1. Lung Adenocarcinoma Diagnosed at a Younger Age Is Associated With Advanced Stage, Female S*x, and Ever-Smoker Status, in Patients Treated With Lung Resection. Dragani TA, Muley T, Schneider MA, et al. . 2023;15(8):2395. doi:10.3390/cancers15082395.
2. Non-Small Cell Lung Cancer (NSCLC) in Young Adults, Age . Hughes DJ, Kapiris M, Podvez Nevajda A, et al. Cancers. 2022;14(24):6056. doi:10.3390/cancers14246056.
3. Lung Cancer in Young Adults Aged 35 Years or Younger: A Full-Scale Analysis and Review. Liu B, Quan X, Xu C, et al. Journal of Cancer. 2019;10(15):3553-3559. doi:10.7150/jca.27490.
4. Young Lung Cancer: From Diagnosis to Survivorship. Florez N, Kiel L, Kaufman R, et al. Frontiers in Oncology. 2025;15:1570143. doi:10.3389/fonc.2025.1570143.
5. Molecular Properties and Survival of Lung Adenocarcinoma in Young Patients. Cimen F, Düzgün S, Aloglu M, Senturk A, Atikcan S. International Journal of Clinical Practice. 2021;75(11):e14646. doi:10.1111/ijcp.14646.
6. Molecular Features of Lung Adenocarcinoma in Young Patients. Chen Z, Teng X, Zhang J, et al. BMC Cancer. 2019;19(1):777. doi:10.1186/s12885-019-5978-5.
7. The Genomic Landscape of Young and Old Lung Cancer Patients Highlights Age-Dependent Mutation Frequencies and Clinical Actionability in Young Patients. Cai L, Chen Y, Tong X, et al. International Journal of Cancer. 2021;. doi:10.1002/ijc.33583.
8. Comprehensive Characterization of Early-Onset Lung Cancer, in Chinese Young Adults. Tian Y, Ma R, Zhao W, et al. Communications. 2025;16(1):1976. doi:10.1038/s41467-025-57309-4.
9. Clinical and Genetic Characteristics of Early-Onset Lung Adenocarcinoma in a Large Chinese Cohort. Xie S, Hu Q, Wu Z, et al. The Annals of Thoracic Surgery. 2025;119(6):1196-1204. doi:10.1016/j.athoracsur.2024.09.014.

Address

110301臺北市信義區吳興街252號, Sinyi District
Taipei
110301

Opening Hours

Monday 09:00 - 17:00
Tuesday 09:00 - 17:00
Wednesday 09:00 - 17:00
Thursday 09:00 - 17:00
Friday 09:00 - 17:00
Saturday 09:00 - 00:00

Telephone

+886227372181

Alerts

Be the first to know and let us send you an email when 邱德生醫師的腫瘤粉專 posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.

Contact The Practice

Send a message to 邱德生醫師的腫瘤粉專:

Share

Share on Facebook Share on Twitter Share on LinkedIn
Share on Pinterest Share on Reddit Share via Email
Share on WhatsApp Share on Instagram Share on Telegram

Category