31/10/2022
Rheumatoid arthritis in people with diabetes
Diabetes mellitus is a systemic disease that causes not only metabolic problems but also many musculoskeletal problems. Arthritis in people with diabetes leads to disability and reduced quality of life. Early assessment and management of rheumatic diseases in patients with diabetes can prevent pain and reduce morbidity and mortality in this group of patients.
1. Limitation of joint movement
Limited range of motion occurs in small joints of the limbs that are more noticeable than in larger joints. However, there is growing evidence that reduced mobility in larger joints, including the hip and shoulder joints, also occurs in people with diabetes.
It is reported that men and women with diabetes are 5.0 to 5.9 times more likely to develop ankylosing spondylitis than those without diabetes. Because of the systemic effects of diabetes complications on collagen tissues, limited mobility can affect every joint in the body, not just the hands, feet, and shoulder joints.
2. Arthritis charcot
Charcot Osteoarthritis, first described by French neurologist Jean-Martin Charcot. It is a progressive degenerative joint disease of the foot and ankle that causes deformity of the ankle joint, affecting walking if left untreated.
Charcot osteoarthritis is also seen in other diseases, but it is more common in patients with diabetes. Men and women are equally affected. The prevalence of the disorder increased with the duration of DM treatment and in the 50-69 year age group.
Initially, there is acute inflammation with red, hot, painful swelling in the feet; Usually found in the midfoot. Fever, pain, and leukocytosis can be alarming for osteomyelitis. It is thought that repeated microtrauma to the foot causes bone disease and trauma. Another proposed hypothesis (neurovascular hypothesis) is that vasodilation causes increased perfusion of this region.
Early diagnosis can prevent unfortunate consequences such as amputation. The disease occurs more frequently in patients with poor glycemic control, and diabetes control is an important part of treatment.
The treatment of Charcot arthritis is based on the stage of the disease. Immobilizing the leg with splints and rest can prevent overloading of the foot joints, can reduce inflammation during the acute phase, and help avoid minimal deformity of the joint. Bisphosphonates have been used therapeutically. It has been shown that the administration of a single 90 mg infusion of pamidronate for 6 months followed by 70 mg of alendronate weekly reduces symptoms, corrects bone markers, and reduces pain. Surgery is not the first treatment option and will be considered in people with chronic foot ulcers.