24/12/2021
Dubbed Alpine Rose Active, Mibelle’s new skin care active has been designed to clear senescent cells, which fasten skin ageing, from aged or stressed cutaneous tissues, using the novel anti-ageing "senolytics" concept for the first time.
Eliminating senescent cells has emerged as a promising anti-aging therapy in the medical field in the past few years. With Alpine Rose Active [1], Mibelle Biochemistry is pioneering the novel “senolytics” concept in the cosmetics field.
“Zombie cells”
When fibroblasts responsible for the production of collagen either age or encounter too many harmful oxidative stresses (such as UV light and pollution), they become senescent. Senescent cells are also called “zombie cells” because they no longer divide, but are also far from being dead. These cells continue to secrete signalling molecules that promote inflammation and can influence surrounding cells into also becoming senescent. In younger tissue, senescent cells are usually cleared by the immune system. In aged skin and skin that has been exposed to consistent stress, senescent cells accumulate. The resulting chronic inflammation exacerbates the aging process by promoting collagen degradation, which leads to a lack of skin elasticity.
