04/14/2026
You might be surprised to learn that there is clinical evidence supporting the value of Astragalus membranaceus in joint problems. In yet another example of the remarkable clinical versatility of medicinal plants, an extract of Astragalus root improved knee pain in a double blind, randomised controlled trial. This was conducted with 90 adults (18 to 60 years of age) from Rajalakshmi Hospital and Research Centre, Karnataka, India. Participants with functional knee pain (not radiographically confirmed osteoarthritis) were randomly assigned to receive either 480 mg/day of a dried hydroethanolic extract of Astragalus root (n = 45) or placebo (n = 45) for 28 days. The primary outcome was knee pain reduction, which was assessed using a visual analogue scale (VAS) after a 6-minute walk test. Secondary outcomes included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Stair Climb Test (SCT), knee range of motion (ROM), and treatment compliance, evaluated at baseline and at follow-up on days 5, 14, and 28. Patient satisfaction and safety were also assessed.
The Astragalus group exhibited a large and significant 82% reduction in knee pain (p < 0.0001), with mean VAS scores dropping from 6.7 ± 0.5 to 1.2 ± 0.6 vs 6.7 ± 0.5 to 5.6 ± 0.9 for placebo. Significant improvements were also observed in the WOMAC, SCT score, and ROM (p < 0.0001). Patient satisfaction was higher in the active treatment group, and no serious adverse events were reported.
Based on earlier published work, the clinical dose likely corresponds to 3 to 4 g of Astragalus root daily. This study provides preliminary evidence for Astragalus in functional knee pain and is a novel clinical finding for this herb. However, replication in larger and longer trials is necessary to establish the reliability of the effect. This modern finding that Astragalus may be a joint mobility herb is not classical Traditional Chinese Medicine (TCM), but on the other hand it is compatible with some aspects of TCM theory.
For more information see: https://pubmed.ncbi.nlm.nih.gov/41235391/