03/24/2026
ASTHMA AND GLP-1RAS
The use of the new injectable medications originally
developed for diabetes has expanded since we have
learned about many of the beneficial effects they may
have beyond the control of blood sugar. Heart benefits,
weight control, and reductions in inflammation are
just a few of the benefits which have been found.
Obesity in adolescents is as much of a problem as it
is in adults. Adolescents who have asthma and obesity
have more problems in controlling their symptoms and
exacerbations than their normal weight counterparts.
Recently, it has been found that adolescent patients who are
obese and have asthma and being treated with a GLP-1RA
have less exacerbations. Like many observations, the reason
for this benefit for these adolescent patients is unclear.
Weight loss has been shown to help reduce the
incidence of asthma exacerbations in obese adolescents,
but the weight loss benefit associated with GLP-1RAs
may not be the only reason these patients have less
problems with their asthma. GLP-1RAs have been shown
to influence inflammation. We should all know by now that
inflammation in the airways is part of the basic pathology
of asthma. How these drugs may accomplish this effect
in the obese adolescent patient is, of course, unclear.
Does this mean that all obese adolescent asthma patients
should be treated with GLP-1RAs, of course not. However,
it may be that if continued observations and research show
significant benefit when using these drugs, parents may find
physicians offering this type of therapy to their children.