NorthShore Weight and Metabolism

NorthShore Weight and Metabolism A premier endocrinology and weight loss practice on the north shore. Our core values include transparency, kindness, integrity and solid ethics.

Our practice takes a holistic, integrative, and patient-centered approach in caring for our patients. NSWM is the premier medical weight loss program on the North Shore. With over 50 years combined experience in the field of weight management - our dedicated staff of medical professionals is focused on helping our patients lose the weight and keep it off! We are the first medically supervised weight loss practice in the North Shore/Amesbury area. Our mission is to provide a welcoming home for individuals looking to free themselves of excess weight, and start a journey together toward better health and happiness. NSWM was founded by Dr. Dominica Costello, DO, who is Board Certified in Endocrinology and Obesity medicine. Having been in active practice since completing fellowship training in 2006, Dr. Costello enjoys practicing all aspects of general endocrinology, with special focus on obesity and nutrition, diabetes and thyroid disease. Our team has expertise in nutrition, health coaching, exercise, behavior and of course medical care. There are many weight loss clinics that claim to help you lose weight, and some of them do work. However, the most effective, safe and PERMANENT way to lose weight is to join a program with a team of medical professionals, well versed in all aspects of weight management. We provide all this and more at North Shore Weight and Metabolism. During these challenging times of COVID-19, we are holding all nutrition coaching, classes, and medical visits using telemedicine. We will soon have a brand new office space in Amesbury, MA. As safety permits, Dr. Costello will soon start seeing patients in person in the office. Please call us at 978-473-3221 if youโ€™re looking for information or would like to set up a virtual consultation. Please browse our website to meet our team of experts, and learn more about the different approaches available for healthy weight loss. We are here to provide a comfortable and positive setting, where you can start a path to a healthier, happier you!

Have a look ladies!!
11/18/2025

Have a look ladies!!

๐Ÿ What a moment.  ๐Ÿ I'm so grateful that this   is FLOODING social media and the regular media to the point that no one ...
11/18/2025

๐Ÿ What a moment.
๐Ÿ I'm so grateful that this is FLOODING social media and the regular media to the point that no one can POSSIBLY be unaware of what has been going on for many years, and what now will change.
๐Ÿ Read! Watch! Listen!

When I raise the topic of with my friends or patients, I will occasionally hear "Oh I don't need that.."
Let's work to change that way of thinking, and change what we define as "need". This is not just about hot flashes and mood swings. This is about better long-term health.

๐Ÿ‘‰ Everyone needs that.



๐Ÿ Learn more about evidence-based menopause care:

www.northshoreweightandmetabolism.com

If you have been on social media in the last 24 hours, you have probably seen the flood of posts about the FDAโ€™s decision to remove the black box warning from menopausal hormone therapy.

07/16/2025

There are lots of misconceptions out there. We asked experts about the biggest offenders.

๐Ÿ Have a look ๐Ÿ‘‡๐Ÿ‘‡
07/16/2025

๐Ÿ Have a look ๐Ÿ‘‡๐Ÿ‘‡

There are lots of misconceptions out there. We asked experts about the biggest offenders.

Hot Flashes & Cool Friends ๐Ÿ”ฅ๐ŸงŠA Menopause Workshop (Yes, Weโ€™re Talking About That)THIS WEDNESDAY!Feeling like your thermo...
05/12/2025

Hot Flashes & Cool Friends ๐Ÿ”ฅ๐ŸงŠ
A Menopause Workshop (Yes, Weโ€™re Talking About That)

THIS WEDNESDAY!

Feeling like your thermostatโ€™s broken? Mood swinging like a playground? Wondering if your memory took an extended vacation?

Join us for a real-talk workshop where we laugh, learn, and sweat (sometimes literally) through all things menopause. Bring your questions, your sense of humor, and your fan (trust us, you'll want it).

Letโ€™s normalize the midlife magic and navigate the pause like the queens we are. ๐Ÿ‘‘
No shame. No fluff. Just hot truths and cool support.



See more information here...and JOIN US!

Motivate looks for opportunities to learn and socialize outside of our normal studio classes. Our workshops and socials are chances to be exposed to different health and movement topics, partake in fundraisers and community-based offerings as well as just connect with your fellow Motivators off the

๐Ÿ This is BEYOND exciting.I have had several patients now, who AFTER starting HRT have noticed subtle improvements in ho...
05/02/2025

๐Ÿ This is BEYOND exciting.

I have had several patients now, who AFTER starting HRT have noticed subtle improvements in how they feel their GLP-1 medication is working. Incredible!

๐Ÿ’™๐Ÿ’š It's definitely a promising concept in helping perimenopausal and postmenopausal women get control of their health and weight.

www.northshoreweightandmetabolism.com

Do GLP-1s work differently in women โ€” and does menopause blunt their effect?
Emerging research suggests the answer is yes. And the missing link may be estrogen.๐Ÿ‘‡

Studies show that women often experience greater weight loss, improved glucose control, and better lipid profiles on GLP-1 receptor agonists (like liraglutide, semaglutide) compared to men. But after menopause, these benefits seem to decline. Why?

๐Ÿงฌ Estrogen appears to enhance GLP-1 efficacy by influencing the same brain regions that regulate appetite, reward, insulin secretion, and metabolic homeostasis.
๐Ÿ“‰ In animal models, estrogen loss impaired GLP-1 responseโ€”and estrogen replacement restored it.
๐Ÿ’ก In humans, women have ~32% greater drug exposure and stronger glycemic response than men, independent of weight. But postmenopausal women often lose this edge.

Thatโ€™s why researchers are now studying GLP-1 + estrogen conjugatesโ€”a targeted therapy that delivers estrogen directly to GLP-1 receptor sites (like the brain and pancreas), avoiding systemic side effects.

In preclinical models, this dual approach leads to:
โœ… Greater weight and fat loss
โœ… Improved glucose tolerance
โœ… Reduced liver fat (MASLD/MASH)
โœ… Enhanced insulin secretion + beta-cell protection
โœ… Appetite regulation without gynecologic side effects

For postmenopausal women with obesity, T2D, or fatty liver, this could be transformative. Because menopause isnโ€™t just a hormonal shiftโ€”itโ€™s a metabolic one.

Precision medicine must include sex-specific therapies that reflect hormonal status and timing. Women arenโ€™t smaller men. We deserve better.

05/02/2025

๐Ÿ Weโ€™re getting better at treating obesityโ€”not just with medications like GLP-1s, but with what comes after the weight loss too.

๐Ÿ One of the biggest challenges? Keeping the weight off once the medication stops.

๐Ÿ’™ A new procedure called Revitaยฎ is showing real promise in helping maintain weight loss after GLP-1 medication by targeting insulin resistance at its sourceโ€”the duodenum. This minimally invasive approach could become a game-changer in metabolic health.
Still in development but TRULY exciting!!!!

๐Ÿ’™ Science is catching up to what weโ€™ve known all along: obesity is not just about willpowerโ€”itโ€™s about biology.

๐Ÿ visit us ๐Ÿ‘‡๐Ÿ‘‡๐Ÿ‘‡๐Ÿ‘‡so we can help launch your weight loss journey!

www.northshoreweightandmetabolism.com

๐Ÿ My advice? Follow as many well-reputed and established experts as possible, to get a jump start on your education abou...
04/29/2025

๐Ÿ My advice? Follow as many well-reputed and established experts as possible, to get a jump start on your education about your health.

๐Ÿ Then come see a local expert to discuss more and get you on your way to a healthier you!

๐Ÿ Have a look at our new MenopauseRx program- visit ๐Ÿ‘‡๐Ÿ‘‡๐Ÿ‘‡

www.northshoreweightandmetabolism.com



Address

110 Haverhill Road Suite 505
Amesbury, MA
01913

Opening Hours

Monday 8am - 5pm
Tuesday 8am - 5pm
Wednesday 8am - 5pm
Thursday 8:30am - 5pm
Friday 8:30am - 5pm

Telephone

+19784733221

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