
07/29/2025
Psilocybin Extends Human Cell Lifespan by Over 50%—New Study Unveils Surprising Longevity Potential
Psilocybin, the psychedelic compound traditionally known for its mind-altering effects, may have a powerful new application: slowing down the biological aging process.
In a groundbreaking study published in npj Aging, scientists from Emory University and Baylor College of Medicine found that psilocybin extended the lifespan of human cells by more than 50%. The researchers treated skin and lung fibroblasts with psilocin—the active form of psilocybin—and observed significantly delayed cellular senescence.
But it gets even more intriguing.
Aging mice given monthly doses of psilocybin had their survival rates jump from 50% to 80% over a 10-month period. The treated mice not only lived longer, but also showed fewer visible signs of aging such as fur whitening and hair loss.
This is the first direct experimental evidence that psilocybin may offer longevity benefits, pushing its potential beyond mental health treatment and into the realm of anti-aging science.
🧪 While further studies are needed to explore long-term effects and optimal dosing, this discovery opens a bold new frontier: psychedelics for life extension.
📖 Source:
Kato, K., Kleinhenz, J.M., Shin, YJ. Psilocybin treatment extends cellular lifespan and improves survival of aged mice. npj Aging 11, 55 (2025).
Psilocybin, the naturally occurring psychedelic compound produced by hallucinogenic mushrooms, has received attention due to considerable clinical evidence for its therapeutic potential to treat various psychiatric and neurodegenerative indications. However, the underlying molecular mechanisms remai...