Brain Tumor Laboratory: Biology and Therapeutics

04/22/2019

04/22/2019

Working hard towards finding a cure for DIPG, a devastating childhood brain cancer! Thank you FOX17 for raising awareness; thank you ChadTough Foundation, Leah's Happy Hearts Foundation and National Institutes of Health-National Institutes of Neurological Disorders and Stroke; Univ of Michigan Rogel Cancer Center and Department of Neurosurgery for supporting our work!

03/31/2019

Our interview for the Detroit News explaining the immune stimulatory gene therapy strategy which could the used to treat children with DIPG. Thank you so much Leah’s Happy Hearts and ChadThough Foundation for all your support which enabled us to get this far! We are truly grateful!

Two UM doctors receive NIH grant to study inoperable pediatric brain cancer that killed Chad Carr at the age of 5 in 2015

11/29/2018

So proud of Pedro Lowenstein for becoming Fellow of the AAAS, after being nominated by his peers for his breakthrough work on developing novel immunotherapies for adult and pediatric high grade gliomas and implementing gene Therapy mediated immunotherapy in glioma patients in the clinic! Phase one trial almost completed, will be reporting results at 2019!

10/03/2018

New: Dr. discusses how science is a highly collaborative endeavor that transcends different barriers, and updates us on her glioma work, in Translational Cancer Research: tcr.amegroups.com/article/view/2…

04/23/2018

Clinical Neuroimmunolgy and Brain Tumors Study Section; incoming Chairperson! Thanks for this recognition!!

More wonderful news out of the Castro & Lowenstein Lab! Dr. Maria G Castro has been named Chairperson of the National Institutes of Health (NIH) Clinical Neuroimmunology and Brain Tumor Study Section for the term of 2018-2020. Please help us congratulate Dr. Castro on her continued success!

02/28/2018

02/25/2018

Our team's mission is to improve the prognosis of adult and pediatric malignant brain tumor patients, by developing effective and novel therapies. Malignant brain tumors are aggressive, invasive, and develop resistance to state of the art therapies. Our team works in close collaboration with basic scientists, neurooncologists, radiation-oncologists, neuropathologists, and neurosurgeons, in order to bring novel Phase 1 clinical trials to patients at the University of Michigan. Our novel immunotherapy, which utilizes gene therapy mediated delivery of an immunestimulatory strategy to boost the patients' immune response against the tumor has been approved by the FDA and is currently recruiting patients at our Institution.

View the trial posted on ClinicalTrials.gov

02/25/2018

UM neuroscientist receives Javits Award to ... - Michigan Medicine
www.uofmhealth.org/.../u-m-neuroscientist-receives-javits-award-continue-studying
Mar 15, 2016 - U-M neuroscientist Maria G. Castro, Ph.D., has been selected to receive the 2016 Javits Neuroscience Investigator Award, an honor that provides up to seven years of research funding for her brain tumor work.