TrueBroc

TrueBroc® glucoraphanin helps to support the body’s immune system by protecting against oxidative Look for TrueBroc® in dietary supplements and Brassica® Teas.

TrueBroc® glucoraphanin helps to support the body’s immune system by protecting against oxidative stress and increasing antioxidant activity. TrueBroc® is the most concentrated source of glucoraphanin from broccoli currently on the market. Brassica® Tea with TrueBroc® glucoraphanin is gourmet full leaf natural green and black tea containing 15 mg of glucoraphanin – we offer six varieties. www.TrueBroc.com

01/28/2026

Dr. , the leading authority on sulforaphane and its biology, and co-founder of Brassica Protection Products (BPP), the manufacturer of TrueBroc®, joins Root of the Cause Radio for an in-depth discussion on how this phytochemical interacts with cancer-relevant biological pathways.

Fahey’s research has been instrumental in shaping current scientific understanding of sulforaphane, from its characterization and bioavailability to its mechanistic and clinical implications. Drawing on decades of work, the conversation examines:
• The role and limits of NRF2 signaling
• Why reductionist, single-target strategies often fall short in oncology
• How sulforaphane influences inflammation, angiogenesis, epigenetic regulation, and cellular stress-response systems
• How to distinguish robust evidence from overextension

A substantive, mechanism-focused discussion led by one of the scientists most closely associated with the field.

🎧 Killing Cancer with Sulforaphane

CancerBiology SystemsMedicine RootOfTheCause

01/14/2026

🎉 USA TODAY BEST-SELLING BOOK! 🎉

We’re thrilled to celebrate our amazing collaborator Ashley Koff RD LLC on the launch of her new book,
Your Best Shot — now a USA TODAY Best-Selling Book, debuting at #89 on the Top 150 Booklist 📚✨

Launching January 6, Your Best Shot offers a personalized, science-based approach to optimal weight health — GLP-1 shot or not — grounded in how the body truly works.

One of the things we deeply appreciate about Ashley’s work is how much time she dedicates to detoxification — not as a trend, but as a foundational biological process. Supporting the body’s natural detox pathways is essential for metabolic health, hormone balance, and long-term resilience.

That’s where compounds like glucoraphanin, converted in the body to sulforaphane, play a powerful role — activating the body’s own detox and cellular defense systems. 🥦

We’re proud to see these conversations moving into the mainstream — and proud to support the science behind them with ®, a trusted source of stabilized glucoraphanin.🥦

Congratulations, Ashley — this is just the beginning. 💛👏

12/16/2025

🎉 We’re proud to recognize Dr. Jed W. Fahey and his co-author Mirran Raphaely on the success of their scientific review, published earlier this year in MDPI Applied Sciences — and now recognized as one of the journal’s most widely read articles.

🥦 The paper explores how sulforaphane, a broccoli-derived bioactive, intersects with sex-specific conditions and hormone balance, including its role in endocrine signaling, inflammation, and cellular defense pathways.

Dr. Fahey’s work builds on a remarkable scientific lineage. Working closely with the late Dr. Paul Talalay — whose trailblazing contributions to biomedical science saw him elected to the U.S. National Academy of Sciences — and Dr. Yuesheng Zhang, this body of research helped establish the modern understanding of sulforaphane, glucoraphanin, and Nrf2 activation.
(Those interested in Dr. Talalay’s life and legacy can read more via the link in our bio.)

🔬This review brings that foundational science forward through a modern, sex-aware lens — underscoring why sulforaphane continues to matter in the future of functional foods, hormone health, and preventative nutrition.

🔬 Published in Applied Sciences (MDPI)
🔗 Link in bio to read the full review

11/30/2025

Ottolenghi’s Roasted Broccoli with Chili & Garlic Oil (Quick Recipe)

Ingredients:
• 1 large head broccoli, cut into long florets
• 3 tbsp olive oil
• 3–4 garlic cloves, thinly sliced
• 1 red chili, finely sliced (or ½ tsp chili flakes)
• Zest of 1 lemon
• 1 tbsp lemon juice
• Salt + pepper
• Optional: toasted almonds or sesame seeds

Method:
1. Heat oven to 220°C / 425°F.
2. Toss broccoli with 2 tbsp olive oil, salt, and pepper.
3. Spread on a tray and roast 15–20 minutes, until edges are charred and crisp.
4. Meanwhile, warm the remaining 1 tbsp olive oil in a small pan. Add garlic and chili.
Cook 1–2 minutes until fragrant (don’t brown the garlic).
5. Remove broccoli from oven. Drizzle with the warm chili–garlic oil.
6. Add lemon zest + juice. Toss gently.
7. Finish with toasted nuts or seeds if you like.

Serve warm or at room temperature. Perfect Thanksgiving side.🙏🥦

11/30/2025

🐶🥦 Did you know sulforaphane may support your pet’s health too?🐱🫶🏼
(Yes — especially your mammal pets.)

At TrueBroc®, we’re known for delivering glucoraphanin — the precursor your body converts into sulforaphane, the molecule that activates the Nrf2 cellular defense pathway. Here’s what’s fascinating: dogs and cats have this same system, and veterinary researchers have shown that their cells respond directly to sulforaphane.

Here’s the pet-specific science worth tracking:
1. Sulforaphane activates Nrf2 in dog and cat cells.
Canine and feline fibroblasts show strong upregulation of Nrf2-controlled antioxidant genes (HO-1, NQO1, GCLC).
Citations: Kim H. et al., Vet Res Commun 2019; Kim H. et al., BMC Vet Res 2020.
2. It boosts natural antioxidant defenses in dogs.
Sulforaphane has been shown to increase glutathione and enhance oxidative-stress resilience in canine models.
Citation: Wakshlag J. et al., Front Vet Sci 2021.
3. It supports healthy inflammatory balance.
In canine immune cells, sulforaphane helps modulate cytokine expression and maintain balanced inflammatory signaling.
Citation: Cho H. et al., J Vet Sci 2020.
4. Dogs and cats don’t convert broccoli into meaningful sulforaphane.
They have limited ability to convert glucoraphanin from raw cruciferous vegetables — meaning standardized, stable sources may be more effective in research settings.
Citation: Carey D., Small Animal Clinical Nutrition 2021.

11/11/2025

😬 If ‘disease creeps in through the gums’, it’s because the mouth is one of the body’s most active inflammatory zones — and a mirror of whole-body health.
In periodontal disease, oxidative stress overwhelms gum tissue and immune cells, disrupting redox balance and accelerating inflammation.

🥦 Sulforaphane, the bioactive phyto-compound in TRUEBROC®, activates the body’s master antioxidant defense — the Nrf2 pathway — helping restore resilience at the cellular level.

🧬 Emerging science:
• Sulforaphane restored glutathione levels and reduced oxidative burst in neutrophils from patients with chronic periodontitis (Dias et al., PLoS One, 2013; 8:e66407).
• SFN activated Nrf2 and reduced mitochondrial ROS and inflammatory mediators in human gingival fibroblasts challenged with P. gingivalis, while attenuating periodontal tissue damage in rats (Liu et al., Int Immunopharmacol, 2025).
• The Nrf2 pathway regulates antioxidant enzymes (HO-1, NQO1, SOD) critical to protecting gum tissue from inflammation and bone loss (Yang et al., Front Endocrinol, 2022).

🦷 These findings link oral health to the same antioxidant networks that TRUEBROC® supports systemically — reminding us that resilience begins at the cellular level.

TRUEBROC®
Proven in nature.
Rooted in science.
Made for resilience.

11/03/2025

🦠Gut health matters!

Meet H. pylori (Helicobacter pylori)— a common bacterium that can live in your stomach lining and is linked to ulcers, chronic inflammation and even increased risk of gastric-cancer when left unchecked.

🔬 Research over the past two decades has shown that sulforaphane can inhibit H. pylori, supporting the body’s natural defense against this common bacterium.

🥦 That’s where TrueBroc comes in. Our premium glucoraphanin/sulforaphane-rich broccoli seed extract supports your body’s natural defence systems and gut environment.

✅ What to remember: - This is not a treatment or cure for H. pylori infection or ulcers. Always consult your healthcare provider.

💡 Tip: If you’re dealing with gut discomfort, recurrent gastritis, or have concerns around H. pylori, focus also on lifestyle: diet rich in cruciferous vegetables, reducing stress, managing sleep and limiting processed food.

🔗 Want to dive deeper? Visit the link in our bio to explore the science behind TrueBroc and gut health.

CITATIONS
Fahey, J. W., Haristoy, X., Dolan, P. M., Kensler, T. W., Scholtus, I., Stephenson, K. K., Talalay, P., & Lozniewski, A. (2002). Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proceedings of the National Academy of Sciences, 99(11), 7610–7615. https://doi.org/10.1073/pnas.112203099

Yanaka, A., Fahey, J. W., Fukumoto, A., Nakayama, M., Inoue, S., Zhang, S., Tauchi, M., Suzuki, H., Hyodo, I., & Talalay, P. (2009). Daily intake of broccoli sprouts reduces Helicobacter pylori infection and attenuates gastritis in human subjects. Cancer Prevention Research, 2(4), 353–360. https://doi.org/10.1158/1940-6207.CAPR-08-0192

Haristoy, X., Angioi-Duprez, K., Duprez, A., & Lozniewski, A. (2003). Efficacy of sulforaphane in eradicating Helicobacter pylori in human gastric xenografts implanted in n**e mice. Antimicrobial Agents and Chemotherapy, 47(12), 3982–3984. https://doi.org/10.1128/AAC.47.12.3982-3984.2003

10/29/2025

🫁 SULFORAPHANE & LUNG CELL HEALTH

In a 2025 human clinical study with former smokers, daily sulforaphane was associated with:

📉 ~20% decrease in Ki-67 cell-proliferation markers in bronchial tissue
📈 ~65% increase in the placebo group

Ki-67 = a biomarker of cellular turnover, and a meaningful signal for respiratory cellular defense.

Why it matters:
• Lower Ki-67 in lung tissue suggests reduced abnormal cell division and improved regulation of cellular turnover
• Cellular turnover means the lungs are better able to deal with damage, stress and renewal
• Sulforaphane supports the NRF2-driven protective systems that help cells stay resilient!

Sulforaphane supports NRF2-regulated protection pathways that help cells manage oxidative stress.

🥦TrueBroc® = standardized glucoraphanin from broccoli seeds → a reliable precursor the body converts to sulforaphane.

SCIENCE FORWARD.
POWERED BY TRUEBROC®.

09/24/2025

🥦 Broccoli Extract Rich in Glucoraphanin (GR) & Sulforaphane (SF) Shows Metabolic Benefits

A new double-blind, placebo-controlled trial found that broccoli extract—naturally rich in glucoraphanin (GR) and its active compound sulforaphane (SF)—significantly lowered fasting blood glucose, improved insulin sensitivity, and reduced liver fat in adults with obesity and metabolic dysregulation.

🔬 How it works: Sulforaphane activates the NRF2 pathway, boosting the body’s own antioxidant and detox enzymes while dialing down liver glucose-production genes (PEPCK, G6Pase).

💡Takeaway:
– Add cruciferous veggies (broccoli, kale, Brussels sprouts) to your plate for natural GR/SF.
– If you’re using a glucoraphanin supplement, choose one with clinical-grade standards. Look for:
• Standardized dose of glucoraphanin proven to yield meaningful sulforaphane.
• Hot-water extraction (not harsh solvents) to preserve activity and avoid residues.
• Independent testing for purity and potency, free of unnecessary fillers or unhealthy excipients.
– TrueBroc® is an example of an ingredient that meets these criteria and is backed by peer-reviewed clinical research.

📚 References:
Dwibedi N et al., Nature Microbiology 2025, doi:10.1038/s41564-025-01932-w
Bahadoran Z et al., Diabetes Care 2012.

09/11/2025

🥦 Sulforaphane & Uterine Health: Science We’re Tracking!

➡️ Early lab studies show sulforaphane (SFN)—the broccoli-derived isothiocyanate—can influence uterine cell biology:

✨Cell-cycle arrest & apoptosis: SFN halted growth and triggered programmed cell death in human endometrial cancer cell lines.【PMC7281543】

✨Pathway modulation: It impacted AKT/mTOR and ERK signaling, key regulators of cell growth and repair.【PMC7281543】

✨Antioxidant defense: SFN activates the Nrf2 pathway, boosting detox enzymes that protect cellular DNA.【Mol Med 2024】

“Sulforaphane’s ability to activate detoxification enzymes and influence hormone-related pathways suggests a broad potential to support women’s gynecological health, though rigorous human trials remain essential.”
— Jed W. Fahey, The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance, Applied Sciences 2025. MDPI
⚠️ Disclaimer: Findings are preclinical (cell/animal data). This is not medical advice and is not evidence of disease prevention or treatment. Always consult a healthcare provider.

08/29/2025

✨Your liver is remarkable-and the body’s primary detoxification organ. Every day it processes hormones, environmental pollutants, and metabolic waste.🗑️💪

🔬 Research shows that sulforaphane—derived from glucoraphanin in broccoli seeds—activates Phase II detoxification enzymes in the liver. These enzymes neutralize and eliminate toxins, reducing oxidative stress and supporting long-term liver health. It’s a game-changer for long term health!

🥦TrueBroc® delivers the ONLY standardized, clinically studied form of glucoraphanin, ensuring consistent sulforaphane activity and measurable benefits.

📚 Key References:
• Zhang Y, et al. Proc Natl Acad Sci USA. 1992;89(6):2399–2403.
• Egner PA, et al. Cancer Prev Res. 2011;4(3):384–395.
• Kensler TW, et al. Cancer Epidemiol Biomarkers Prev. 2012;21(12):2273–2283.

08/12/2025

👀Our eyes are under constant stress—from sunlight to blue light and environmental pollution.

Sulforaphane, released from TrueBroc®’s glucoraphanin, activates your body’s natural antioxidant systems—helping protect delicate eye cells.

✨Retina protection: Preclinical studies show that sulforaphane preserves light-sensitive cone cells in the retina—crucial for color vision—slowing age-related macular degeneration in model systems.
✨Cellular defense: In human retinal pigment epithelial cells (ARPE-19), sulforaphane combats oxidative damage and restores antioxidant enzymes like SOD and catalase.
✨Broad eye‑protection potential: A 2024 review reports that, in animal models, sulforaphane protects corneal and lens epithelial cells—and may delay retinal degeneration associated with cataracts, AMD, diabetic retinopathy, and more—by activating antioxidant pathways (e.g., Nrf2).

🥦So, why TrueBroc®?🤔
Its high‑purity glucoraphanin ensures effective sulforaphane release and reliable antioxidant activation. ✨

Why it matters:
• Supports the body’s natural defense against oxidative stress
• Helps maintain healthy cells in the retina and lens
• Protects against age-related damage from UV and blue light exposure

Give your vision the care it deserves—starting from within.
💚 TrueBroc®

📖References
1. Brassica Protection Products. Health Benefits of TrueBroc®.
https://brassica.com/science/health-benefits-of-truebroc/
2. Oklahoma Medical Research Foundation (OMRF). Certain veggies may prevent eye disorder, OMRF scientist finds. February 15, 2023.
https://omrf.org/2023/02/15/certain-veggies-may-prevent-eye-disorder-omrf-scientist-finds/
3. Chen, Y., et al. (2021). Sulforaphane protects ARPE-19 cells from oxidative damage by activating the Nrf2 pathway. Frontiers in Medicine, 8, 685032.
https://www.frontiersin.org/articles/10.3389/fmed.2021.685032/full
4. Zhang, Y., et al. (2024). Protective Effects of Sulforaphane on Ocular Diseases: Insights from Preclinical Studies. Nutrients, 16(2): 245.
https://pubmed.ncbi.nlm.nih.gov/39139965/

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