03/27/2026
A thought I have been thinking and writing through for months finally made it to paper.
One question kept nagging at me with the rise of more and more negative APOE4 news I see daily... and I keep thinking to myself, if APOE4 is this dangerous, broken gene, why do roughly 25% of humans still carry it? From an evolutionary standpoint, it rarely makes mistakes.
The more I dug into the evolutionary timeline, biochemistry, lipoprotein science, and ancestral diet studies, the clearer the picture became. I dont think APOE4 is broken, coming from someone who has two of them... It is a gene shaped for a specific world: cold environments, physical demand, animal based nutrition, and intermittent feeding. It's essentially a gene that has been discarded with modern living. The mismatch is what we are seeing in the disease data, not the gene itself.
I've put together a fully referenced hypothesis paper. Spanning 27 citations and testable predictions. The folks who know me for health and nutrition, give it a read. If you also have an APOE3 or 4. Give it a read; it may change how you think, too.
Daniel Duane Babcock Jr. Chief Executive Officer, TeamBabcock, Nutrition; Principal Infrastructure Architect, FlightSafety International; Founder, Never Settle Solutions Independent Researcher — Nu…