02/23/2026
I get questions all the time about the best dosing interval for GLP-1s. Weekly, twice weekly, microdosing....etc.
Here's the best answer:
The amount of the dose typically determines how HIGH your medication levels get (and thereby your maximum appetite suppression and risk of side effects).
How often you dose typically determines how LOW your medication levels get before your next dose.
The closer your doses are together, the less variability there will between maximum medication levels.
At our clinic, we set a target medication level and our application allows us to calculate both the exact dose needed to hit that level with any individual dose, and also to set the preferred dosing interval depending on how tightly the patient wants their levels to be controlled.
I've attached two photos--both patients have the same target level (how high their medication levels get).
However, one patient doses once a week and has a lot more variability in their levels. This gives them more dietary freedom and flexibility towards the end of the week.
The other patient doses every 3 days. The peak level is the same--but they stay much closer to that line on average.
To summarize: need more appetite suppression? Increase your target level. Want tighter control? Take the dose needed to hit that level more often.
To learn more, visit Voafit.com/mylevel or feel free to ask questions in the comments!