04/24/2024
What Is Narcolepsy?
Narcolepsy is a disorder that disrupts sleep-wake processes. This disruption can cause excessive sleepiness, the primary symptom of narcolepsy, and make it hard for people with narcolepsy to stay awake for long periods of time.
Normal sleep unfolds through a series of stages, with rapid eye movement (REM) sleep occurring in the final stage, usually an hour or more after falling asleep. In narcolepsy, changes in the brain disrupt how sleep works. As a result, REM sleep is irregular and often begins within minutes after falling asleep, which is much earlier than normal. The inability to properly regulate the sleep cycle can lead to serious problems during the day.
According to the International Classification of Sleep Disorders, American Academy of Sleep Medicine (AASM)AASM sets standards and promotes excellence in sleep medicine health care, education, and research. (ICSD-3), there are two types of narcolepsy: narcolepsy type 1 (NT1) and type 2 (NT2).
Narcolepsy Type 1
NT1 is associated with the symptom of cataplexy, which is the sudden loss of muscle tone. However, not everyone who is diagnosed with NT1 experience episodes of cataplexy. NT1 can also be diagnosed when a person has low levels of hypocretin-1, a chemical in the body that helps control wakefulness.
Narcolepsy Type 2
People with NT2 have many similar symptoms as people with NT1, but they do not have cataplexy or low levels of hypocretin-1. Other sleep disorders also have similar symptoms to those found in NT2, which can make it hard to diagnose.
If a person with NT2 later develops cataplexy or low hypocretin-1 levels, their diagnosis can be reclassified as NT1.
Narcolepsy affects the brain's ability to regulate sleep-wake cycles and causes persistent daytime sleepiness. Additional symptoms include disrupted sleep, sleep paralysis, and sleep-related hallucinations. Treatment for narcolepsy focuses on managing symptoms and reducing accident risk.
Narcolepsy is a chronic neurological disorder that affects the brain's ability to control sleep-wake cycles. People with narcolepsy experience excessive daytime sleepiness and intermittent, uncontrollable episodes of falling asleep during the daytime. These sudden sleep attacks may occur during any type of activity at any time of the day.
• Narcolepsy affects the brain’s ability to regulate sleep-wake cycles and causes persistent daytime sleepiness.
• Additional symptoms include disrupted sleep, sleep paralysis, and sleep-related hallucinations.
• Treatment for narcolepsy focuses on managing symptoms and reducing accident risk.
Narcolepsy is a sleep disorder that is often misunderstood. It is characterized by severe and persistent drowsiness that can cause impairments in school, work, and social settings as well as heighten the risk of serious accidents and injuries.
Although rare in comparison to many other sleep disorders, narcolepsy affects hundreds of thousands of Americans, including both children and adults. How Common Is Narcolepsy?
Narcolepsy is relatively rare. NT1 affects between 20 and 67 people per 100,000 in the United States. According to a population based study in Olmstead county Minnesota, NT1 is two to three times more common. The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information.
Calculating the prevalence of narcolepsy is challenging because of underdiagnosis and delays in diagnosis. Many people are not diagnosed with narcolepsy until years after their first symptoms , some estimates place the prevalence of narcolepsy as high as 180 per 100,000.
Narcolepsy occurs roughly equally in men and women and can affect both children and adults. It can occur at any age, but onset has been found to peak at around age 15 and again around age 35.
Mental and Physical Effects: Narcolepsy can have significant effects both physically and mentally. Physically, it can lead to disturbed night-time sleep, sleep paralysis, and cataplexy, a sudden loss of muscle tone triggered by strong emotions which can lead to physical collapse. There is also an increased risk of accidents due to sudden sleep attacks.
Mentally, narcolepsy can cause difficulties such as poor concentration, reduced memory capacity, and mental clouding. It can also lead to emotional and psychological issues, such as depression, anxiety, and social withdrawal due to the fear of having sleep attacks in public. Narcolepsy Treatments:
There is no cure for narcolepsy type 1 or type 2. The goals of treatment for narcolepsy are improving symptoms, reducing risks, and enhancing quality of life.
For many people, narcolepsy remains generally stable over time. In some cases, certain symptoms may improve over time, and rarely, remission of symptoms may happen spontaneously. So far, experts do not know why the disease unfolds differently in different people.
A combination of medical and behavioral approaches can significantly decrease symptoms, although some level of EDS normally persists despite treatment. All therapies should be carried out under the guidance of a doctor who can best tailor a treatment plan to a person’s specific situation.
Behavioral Approaches to Treatment
Behavioral approaches are non-medical forms of therapy, and there are multiple ways that they can be incorporated into the daily habits of people with narcolepsy.
• Planning short naps: Because brief naps are refreshing for people with narcolepsy, budgeting time for naps during the day can reduce EDS. Accommodations at school or work may be necessary to make time for naps.
• Having healthy sleep hygiene: To combat poor sleep at night, people with narcolepsy can benefit from good sleep habits. Good sleep hygiene includes a consistent sleep schedule, a sleep environment with minimal distractions, and limited use of electronic devices before bed.
• Avoiding alcohol and other sedatives: Any substance that contributes to sleepiness may worsen daytime narcolepsy symptoms.
• Driving with caution: People with narcolepsy should talk with the doctor about safe driving. Measures to improve safety could include napping before driving and avoiding long drives.
• Exercising and eating a balanced diet: People with narcolepsy have a higher risk of obesity, which makes exercise and eating well an important part of their overall health.
• Seeking support: Support groups and mental health professionals can promote emotional health and counteract the risks of social withdrawal, depression, and anxiety in people with narcolepsy.
Medications
Although behavioral approaches are frequently helpful, medications for narcolepsy often provide symptom improvement. These drugs require a prescription and should be used carefully and according to the instructions provided by a doctor and pharmacist:
• Modafinil and armodafinil: These two wakefulness-promoting drugs are chemically similar and are typically the first therapy for EDS.
• Methylphenidate: This is a type of amphetamine that can reduce EDS.
• Solriamfetol: This drug was approved by the FDA in 2019 National Library of Medicine, Biotech InformationThe National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information.
• Sodium oxybate: This medication can reduce cataplexy, EDS, and nighttime sleep disturbances, but it may take weeks to affect EDS National Library of Medicine, Biotech InformationThe National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. .
• Pitolisant: Approved by the FDA in 2019, pitolisant is a wakefulness-promoting medication that has also shown a positive effect on cataplexy.
Not all medications work for all patients. Working closely with the doctor can help identify the medication and dosage with the best balance of benefits and downsides.
Treatment: There is currently no cure for narcolepsy, but the symptoms can be managed with medical treatment and lifestyle changes. Medications used to treat the condition include stimulants, such as modafinil and armodafinil, to control sleepiness, and antidepressants to manage symptoms of cataplexy, sleep paralysis, and hallucinations. Sodium oxybate can also be used to improve nighttime sleep and control daytime sleepiness and cataplexy.
Lifestyle changes that can help manage narcolepsy include having a regular sleep schedule, taking scheduled naps during the day, maintaining a healthy diet and regular exercise, and avoiding caffeine and alcohol. Cognitive behavioral therapy may also be beneficial for managing the psychological impacts of narcolepsy.
It's important to note that treatment is individualized based on the severity of the symptoms and the patient's general health, age, and tolerance for specific medications or therapies. Regular follow-up care is essential to adjust the treatment as necessary.
DISCLAIMER: THIS TEXT DOES NOT PROVIDE MEDICAL ADVICE. IT IS INTENDED FOR INFORMATIONAL PURPOSES ONLY. IT IS NOT A SUBSTITUTE FOR PROFESSIONAL MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT. ALWAYS SEEK THE ADVICE OF YOUR PHYSICIAN OR OTHER QUALIFIED HEALTH PROVIDER WITH ANY QUESTIONS YOU MAY HAVE REGARDING A MEDICAL CONDITION.
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Quazi Imam, M.D. Board Certified in Psychiatry. Board Certified in Addiction Psychiatry. Board Certified in Geriatric Psychiatry. Board Certified in Forensic Psychiatry. Former Assistant Professor of Psychiatry, Mount Sinai School of Medicine, NY. Child & Adolescent Psychiatrist, Harvard Medical School Trained.