
02/24/2025
A 2024 systemic review and meta-analysis looked at zinc deficiency in RPL...
..here is what they found after reviewing studies published between 1980 and 2022...
...higher zinc levels were protective against miscarriage.
Preconception zinc levels are more important than zinc consumption in the first trimester. Serum zinc levels normally decrease in pregnancy. There is increased liver storage and decreased albumin-zinc binding. Add hemodilution to this, and serum zinc levels normally drop.
But big drops may be a sign of zinc deficiency.
Immediately after fertilization, the egg releases a burst of zinc—known as the "zinc spark." This release helps block additional s***m (a mechanism to prevent polys***my) and initiates embryonic development.
Zinc is a cofactor for over 300 enzymes, including those for DNA synthesis, cell division, and antioxidant defense. These enzymes support rapid cell proliferation and genomic stability during early embryonic development.
Zinc is essential for the proper function of both innate and adaptive immune cells (e.g., T cells and natural killer cells). It helps regulate inflammation, preventing excessive immune reactions that could harm the developing embryo.
Zinc is also required for thyroid hormone production and function. Thyroid hormone production increases by 25% in the first trimester to fuel the metabolic needs of rapid cell proliferation and trophoblast invasion.
All of these mechansisms can be affected in preconception zinc deficiency and lead to higher miscarriage risks.
..and we are not even talking about the s***m zinc contribution..