07/22/2023
Newly published work by my former graduate student, Laura Schubert as well as Anh Le and the Heasley and Nemenoff Labs. We developed a rapid way to screen and induce CRISPR-based oncogenic gene fusions. We demonstrated successful induction of Kif5b-Ret, Trim24-Ret, and Tpm3-Ntrk1 gene fusions in vitro as well as successful induction of lung tumors bearing Trim24-Ret in vivo. We believe this technique will help generate multiple novel syngeneic tumor models for oncogenic gene fusions which will aid in studying the role of immune therapies and the tumor microenvironment in these cancers. https://pubmed.ncbi.nlm.nih.gov/37470475/
