
09/06/2024
Unlocking the therapeutic potential of probiotics in mental health! ๐ฑ
In a groundbreaking study, patients hospitalized for mania (N = 66) were randomly assigned after discharge to receive 24 weeks of adjunctive probiotics (Lactobacillus rhamnosus strain GG and Bifidobacterium animalis subsp. lactis strain Bb12) or adjunctive placebo in a parallel two-group design format. ๐
The results were remarkable: During the 24-week observation period, individuals who received probiotics experienced significantly fewer rehospitalizations compared to those who received placebo (z = 2.63, P = .009). ๐
Moreover, probiotic treatment led to fewer days rehospitalized, with the greatest impact observed in individuals with elevated levels of systemic inflammation at baseline. ๐ก
Conclusion: Probiotic supplementation shows promising results in reducing the rate of rehospitalization among patients discharged following mania-related hospitalization. ๐ฅ
Trial registration: ClinicalTrials.gov NCT01731171.
PMID: 2969375
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