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Global Medical Communications GMC Delivering Multi-channel, Patient-focused Medical Communications Created by Global Community of Clin

10/09/2021

We at team GMC, the professionals representing medical affairs, clinical practice and media thought to join forces, to create and disseminate truly patient-focused medical communications which could help for clinical practice decision-making for an improved real world patient management.

Interested in learning more? Get started: https://bit.ly/3zvD2Wc

10/08/2021

In the study, published Sept. 20 in Nature Cancer, the researchers identified a set of anti-immunosuppressive factors that can be secreted by cells called club cells that line airways in the lungs. They showed in a mouse model of lung cancer that these club cell factors inhibit highly potent immunosuppressive cells called myeloid-derived suppressor cells (MDSCs), which tumors often recruit to help them evade antitumor immune responses.

Ref: https://bit.ly/3lQuODe

10/06/2021

Pioneering research shows that dopamine levels increase in response to stressful stimuli, and not just pleasurable ones, potentially rewriting facts about the "feel-good" hormone—a critical mediator of many psychiatric diseases. This discovery is cause to rethink treatment for psychiatric disease and addiction.

Ref: https://bit.ly/3u4WIPB

10/04/2021

The researchers also observed that when participants listened to the ending of long, repetitive sections within K448, a type of electrical activity known as theta activity increased in their frontal cortices. Previous research has suggested that theta activity may be associated with positive emotional responses to music.

Ref: https://go.nature.com/2ZfO6KF

10/03/2021

Immunotherapy drugs are promising new weapons in the fight against cancer, but they are so strong that they can be toxic to the rest of the human body. The basic idea behind immunotherapy drugs is simple.

Doctors inject special kinds of drugs, especially proteins such as antibodies and cytokines prepared or modified in a lab, into a patient, where they activate the patient's immune cells—T-cells, NK cells, and so on—and help these cells fight the tumor.

In short, immunotherapy drugs work like a powerful cocktail that boosts a patient's own immune system.

Ref: https://bit.ly/3hVNNLo

10/02/2021

In a "first of its kind" study, researchers also found a potential direct connection between neurodegenerative diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS), glaucoma, and the herpesvirus, said Dr. Deepak Shukla, the Marion H. Schenk Esq. Professor in Ophthalmology for Research of the Aging Eye, and vice chair for research at UIC.

Ref: https://bit.ly/2ZmdZsr

10/01/2021

We believe this can become a therapy for muscular dystrophy, including the many different forms of muscular dystrophy," said senior study author Elizabeth McNally, MD, Ph.D., director of the Center for Genetic Medicine and the Elizabeth J. Ward Professor of Genetic Medicine. "Given the success with so many other antibodies in treating chronic human diseases like rheumatoid arthritis and psoriasis, we are very optimistic this antibody can translate into the human disease setting."

Ref: https://bit.ly/2ZbDvAo

09/29/2021

Previous models assumed that only large droplets pose a relevant risk of infection because small droplets evaporate quickly. At TU Wien (Vienna), however, in cooperation with the University of Padova, it has now been shown that this is not true: Due to the high humidity of the air we breathe, even small droplets can remain in the air much longer than previously assumed. The study was published in the scientific journal PNAS.

Ref: https://bit.ly/39qeHGL

09/27/2021

A study led by researchers at the UCLA Jonsson Comprehensive Cancer Center has found that treating women with HER2 positive metastatic breast cancer with the HER2-targeting antibody-drug conjugate trastuzumab deruxtecan (T-DXd) significantly prolongs the length of time the disease is controlled and cancer growth is halted when compared to the current standard of care, trastuzumab emtansine (T-DM1).

Ref: https://bit.ly/3hYb2Vs

09/26/2021

Our mission is to Deliver Multi-channel, Patient-focused Medical Communications Created by Global Community of Clinical Experts, Patients’ Organizations, Industry Experts, To Improve Real World Patient Care.

Dedicated to your success: https://bit.ly/3zvD2Wc

09/25/2021

The device, which takes readings every two minutes and wirelessly transmits them to the cloud, was able to quickly detect adverse events that affect body temperature, like infection and cytokine release syndrome, allowing for swifter interventions, according to findings published in Cancer Cell.

Ref: https://bit.ly/3BFRA7o

09/24/2021

Acute decompensated heart failure (ADHF) is a life-threatening and costly disease. Controversy remains regarding the efficacy and renal tolerability of ultrafiltration for treating ADHF. The authors of this article carried out meta-analysis to evaluate this clinical issue.

Ref: https://bit.ly/3jDFfu8

09/22/2021

In a study published this month in Physiology & Behavior, research teams at the University of Tsukuba, led by Takeshi Nishiyasu, and at Niigata University of Health and Welfare, led by Tomomi Fujimoto, have found that, when exercising, people cannot perceive decreases in their core body temperature caused by the cold as well as they can when they are resting. This research has implications for recreational activities in colder climates, such as hiking and skiing.

Ref: https://bit.ly/3tbk31G

09/20/2021

The researchers, with first author Ewelina Bartoszek, did their experiments in zebrafish, but the habenula is so important that evolution has ensured it is found in all vertebrates, from fish to mammals to humans. In fact, earlier studies in humans have found links between dysfunctions in the habenula to neurological conditions such as mood disorders and addiction.

Ref: https://bit.ly/3DLYhX0

09/19/2021

This discovery adds to the growing knowledge base around the huge potential of T cell-based vaccines, including second generation COVID-19 vaccines, that would target lung tissue directly.

Ref: https://bit.ly/2WNsKTI

09/18/2021

Findings suggest a dysfunction in range adaptation in individuals along the spectrum of schizophrenia, ranging from patients with established clinical diagnosis to individuals with subclinical features of psychopathology. Such range adaptation may index a potential underlying mechanism of amotivation in schizophrenia spectrum disorders.

Ref: https://bit.ly/3n04VTU

09/17/2021

Led by Professor Eric Chan from the NUS Department of Pharmacy, the team has identified three new urinary biomarkers that could be used to detect consumption of ADB-BUTINACA, an emerging synthetic cannabinoid which is a type of new psychoactive substance (NPS). The innovative approach used to identify the biomarkers can be applied to other existing and new synthetic cannabinoids.

Ref: https://bit.ly/3gXJ2Rl

09/15/2021

Writing in a paper publishing August 31, 2021 in eLife, the team describes the first adult human "lung-in-a-dish" models, also known as lung organoids that represent all cell types. They also report that SARS-CoV-2 infection of the lung organoids replicates real-world patient lung infections, and reveals the specialized roles various cell types play in infected lungs.

Ref: https://bit.ly/3DKPfd9

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