10/17/2025
⭐Tiny Fat Messengers May Link Obesity to Alzheimer’s Plaque Buildup
Summary: A groundbreaking study reveals how obesity may drive Alzheimer’s disease through tiny messengers called extracellular vesicles released from fat tissue. These vesicles carry lipids that alter how quickly amyloid-β plaques form, a hallmark of Alzheimer’s.
Because they can cross the blood-brain barrier, they act as a direct communication line between body fat and the brain. Targeting these messengers could open new ways to prevent or slow dementia in at-risk individuals.
Key Facts:
▶Fat-to-Brain Link: Extracellular vesicles from body fat can cross the blood-brain barrier.
▶Plaque Formation: Vesicle lipids in obese individuals promote faster amyloid-β clumping.
▶Therapeutic Potential: Blocking this signaling may reduce Alzheimer’s risk in obesity.
Source: Houston Methodist
Read more below:
https://neurosciencenews.com/obesity-alzheimers-neurology-29760/