03/10/2025
šØ Perimenopause & Chronic Disease: The Overlooked Crisis šØ
A new longitudinal study confirms what Iāve seen every day in my practiceāchronic health conditions donāt appear one at a time in perimenopause. Instead, they cluster together, creating a perfect storm for long-term health risks that often go undiagnosed and untreated until itās too late.
š Key Findings from 3,990 Women (Ages 40-65):
ā
Multimorbidity (2+ chronic diseases) is the norm, not the exception.
77.7% had at least two chronic conditions at their first medical exam.
That number jumped to 87% over time.
ā
The most common condition pairing?
Obesity & dyslipidemia (high cholesterol & triglycerides).
ā
Central obesity (belly fat) plays a major role in worsening metabolic health.
š” Why This MattersāAnd What I See in My Patients
Perimenopause isnāt just about hot flashesāitās a critical window for disease prevention. In my practice, I see women dismissed with āitās just agingā when, in reality, their hormonal shifts are accelerating metabolic dysfunction.
As estrogen declines, women are at increased risk for:
š¹ Cardiovascular disease
š¹ Type 2 diabetes
š¹ Hypertension (high blood pressure)
š¹ Metabolic syndrome
š¹ Non-alcoholic fatty liver disease (NAFLD)
Yet, many women never receive proper screening or interventionāuntil these conditions become full-blown diseases.
š The Solution?
This study reinforces the urgent need for proactive, personalized health strategies, including:
āļø Hormone therapy for metabolic protection
āļø Early cardiovascular & metabolic screenings
āļø Lifestyle interventions tailored to perimenopause
I see this every dayāperimenopause is a health crossroads, and how we manage it now determines long-term health outcomes.
š Reference: Luo et al., Analysis of Multimorbidity Patterns in Perimenopausal Women, Climacteric, 2025. DOI: 10.1080/13697137.2025.2470449