08/23/2025
This dives into the connection between migraine aura—temporary visual or sensory disturbances—and the headache phase. Often, the assumption has been: aura happens → cortical spreading depression/depolarization (CSD) occurs → headache follows. However, this points out it might be a little more complicated. 𝗔𝘂𝗿𝗮 𝗱𝗼𝗲𝘀𝗻’𝘁 𝗮𝗹𝘄𝗮𝘆𝘀 𝘁𝗿𝗶𝗴𝗴𝗲𝗿 𝗵𝗲𝗮𝗱𝗮𝗰𝗵𝗲, 𝗮𝗻𝗱 𝗵𝗲𝗮𝗱𝗮𝗰𝗵𝗲 𝗱𝗼𝗲𝘀𝗻’𝘁 𝗮𝗹𝘄𝗮𝘆𝘀 𝗻𝗲𝗲𝗱 𝗮𝘂𝗿𝗮.
We know from lab models how CSD can set off pain pathways, but real-world patients 𝘃𝗮𝗿𝘆 𝗴𝗿𝗲𝗮𝘁𝗹𝘆 and thus, treatments can't be built on a one-size-fits-all model.
Before committing to a class of medications based off a migraine diagnosis alone, 𝘀𝗧𝗠𝗦 𝗼𝗳𝗳𝗲𝗿𝘀 𝗮 𝗯𝗶𝘁 𝗼𝗳 𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗮𝗻𝗱 𝘀𝗮𝗳𝗲𝘁𝘆 𝗮𝘀 𝗮 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 — Single-pulse Transcranial Magnetic Stimulation (sTMS) works by calming cortical hyperexcitability and interrupting the pain cascade—whether the migraine starts with aura or without aura..
Multiple trials show that sTMS can treat acute migraine and prevent future attacks, regardless of aura patterns. 𝗧𝗮𝗿𝗴𝗲𝘁𝗲𝗱 𝗰𝗲𝗻𝘁𝗿𝗮𝗹 𝗻𝗲𝘂𝗿𝗼𝗺𝗼𝗱𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝘁𝗵𝗮𝘁 𝗮𝗱𝗱𝗿𝗲𝘀𝘀𝗲𝘀 𝗺𝗶𝗴𝗿𝗮𝗶𝗻𝗲 𝗮𝘁 𝗶𝘁𝘀 𝘀𝗼𝘂𝗿𝗰𝗲.
No surprise, science of migraine is complex, and treatment strategies can adapt. SAVI Dual sTMS Migraine Therapy is one of those strategies.
🧠✨ New Publication ✨🧠 Thrilled to share our new essay in PLOS Biology: "The mysterious link between migraine aura and migraine headache" 🔗 https://lnkd.in/d-9prd2M Migraine aura remains one of the most intriguing phenomena in clinical neuroscience. While cortical spreading depolarizatio...